{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T06:51:36Z","timestamp":1769151096159,"version":"3.49.0"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,12,7]],"date-time":"2020-12-07T00:00:00Z","timestamp":1607299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Sertoli-Leydig cell tumors (SLCTs) are rare sex-cord stromal tumors of the ovary. Heterologous components may be present, most commonly in the intermediate differentiated and poorly differentiated groups. Because of their scarcity, SLCTs with heterologous differentiation represent a challenge in both diagnosis and management, with limited available experience.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Presentation of case<\/jats:title>\n                    <jats:p>We report a case of a 27-year-old, Tunisian woman, followed in the Dermatology Department since the age of six months for xeroderma pigmentosum, with a history of basal cell carcinoma of the face operated on several times. The patient presented with abdominal pain and bloating associated with a medium abundance ascites on physical exam. Ultrasound showed a large left adnexal mass associated with an elevated cancer antigen 125 on serological exam. The patient underwent unilateral salpingo-oophorectomy with resection of two omental nodules. Microscopic examination concluded to poorly differentiated Sertoli-Leydig tumor with rhabdomyomatous differentiation. Adjuvant chemotherapy was performed and there was no clinical evidence of tumor recurrence during the three years of follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>SLCTs with rhabdomyomatous differentiation on the setting of xeroderma pigmentosum are exceptional, microscopic diagnosis and management is challenging, considering the tumor scarcity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Further case reports and retrospective studies are required to more understand the pathogenesis of SLCTs and to determine their optimal treatment regimen.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2020.12.019","type":"journal-article","created":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T01:26:03Z","timestamp":1608168363000},"page":"288-291","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Inhabitual presentation of Sertoli-Leydig cell tumor of the ovary with xeroderma pigmentosum"],"prefix":"10.1097","volume":"78","author":[{"given":"Ahlem","family":"Bdioui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahlem","family":"Bchir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nabiha","family":"Missaoui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajer","family":"Hamchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sihem","family":"Hmissa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moncef","family":"Mokni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-64-20260114","first-page":"1176","article-title":"Sertoli-Leydig cell tumor with heterologous element: a case report and a review of the literature","volume":"7","author":"Chen","year":"2014","journal-title":"Int. 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Ovarian Res"},{"key":"R5-64-20260114","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1002\/1097-0142(19821201)50:11<2465::AID-CNCR2820501135>3.0.CO;2-U","article-title":"Ovarian Sertoli-Leydig cell tumors with heterologous elements: a clinicopathologic analysis of twelve cases","volume":"50","author":"Prat","year":"1982","journal-title":"Cancer"},{"key":"R6-64-20260114","doi-asserted-by":"crossref","first-page":"4587296","DOI":"10.1155\/2017\/4587296","article-title":"Sertoli-Leydig cell tumor with concurrent rhabdomyosarcoma: three case reports and a review of the literature","volume":"2017","author":"Plastini","year":"2017","journal-title":"Case Rep. Med"},{"key":"R7-64-20260114","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.gore.2015.08.001","article-title":"Poorly differentiated Sertoli-Leydig tumor with heterologous, high-grade, sarcomatoid features: a case report","volume":"14","author":"Brightwell","year":"2015","journal-title":"Gynecol. Oncol. 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A clinicopathologic study of 64 intermediate and poorly differentiated neoplasms","volume":"8","author":"Zaloudek","year":"1984","journal-title":"Am. J. Surg. Pathol"},{"key":"R11-64-20260114","first-page":"281","article-title":"Xeroderma pigmentosum: beyond skin cancer","volume":"6","author":"Lichon","year":"2007","journal-title":"J. Drugs Dermatol"},{"key":"R12-64-20260114","doi-asserted-by":"crossref","first-page":"BSR20180114","DOI":"10.1042\/BSR20180114","article-title":"The association of polymorphisms in nucleotide excision repair genes with ovarian cancer susceptibility","volume":"38","author":"Zhao","year":"2018","journal-title":"Biosci. 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