{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:26:23Z","timestamp":1787498783398,"version":"build-2736575974"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T00:00:00Z","timestamp":1610496000000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,1]]},"abstract":"Abstract<\/jats:title>\n \n Introduction<\/jats:title>\n Segmental aganglionosis (the absence of ganglions) is a rare presentation of Hirschsprung\u2019s disease, whereby only limited segment\/segments of aganglionic bowel is interposed between segments of innervated bowel, or \u201cskip\u2019\u2019 area of normal innervations is present within an area of aganglionosis.<\/jats:p>\n <\/jats:sec>\n \n Presentation of case<\/jats:title>\n We reported a case of a 3 day old male newborn who presented with failure to pass meconium along with progressive abdominal distension. There were skip lesions present in between. Mikulicz double barrel enterostomy was carried out, which was followed by an uneventful postoperative period. Four months later, the patient was admitted for levelling biopsies which revealed the absence of ganglions in the terminal ileum as well as in the rectosigmoid junction. But the ganglions were present in between and proximal to the terminal ileum where the previously dilated small bowel segment was resected. This presentation was contradicted the most accepted migration theory of Hirschsprung\u2019s disease.<\/jats:p>\n <\/jats:sec>\n \n Discussion<\/jats:title>\n As seen in our case, and in21 other cases published between 1954\u20132016, we highly recommend that leveling\/mapping biopsies should definitely include the cecal pole and the small bowel segments proximal to the ileocecal valve as well as the multilevel colonic biopsies down till the rectum.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Reporting of these cases brings out interesting questions with respect to the pathogenesis and serves to highlight the existence of several variants within the spectrum of Hirschsprung\u2019s disease.<\/jats:p>\n <\/jats:sec>\n \n Highlights<\/jats:title>\n <\/jats:sec>","DOI":"10.1016\/j.ijscr.2021.01.049","type":"journal-article","created":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T02:37:32Z","timestamp":1610937452000},"page":"243-247","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Questioning the failure of neural crest cell migration theory in Hirschsprung\u2019s disease"],"prefix":"10.1097","volume":"79","author":[{"given":"Ahmed","family":"Almumtin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-55-20260114","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1203\/00006450-200105000-00001","article-title":"Intestinal motility disorders and development of the enteric nervous system","volume":"49","author":"Gariepy","year":"2001","journal-title":"Pediatr. 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Engl"},{"key":"R5-55-20260114","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1136\/adc.47.252.233","article-title":"Zonal colonic aganglionosis, a variant of Hirschsprung\u2019s disease","volume":"47","author":"MacIver","year":"1972","journal-title":"Arch. Dis. Child"},{"key":"R7-55-20260114","first-page":"568","article-title":"A genetic study of Hirschsprung disease","volume":"46","author":"Badner","year":"1990","journal-title":"Am. J. Hum. Genet"},{"key":"R8-55-20260114","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.jpedsurg.2007.09.005","article-title":"Imperforate anus, malrotation, and Hirschsprung\u2019s disease with double zonal aganglionosis: an extremely rare combination","volume":"43","author":"Oshio","year":"2008","journal-title":"J. Pediatr. Surg"},{"key":"R9-55-20260114","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3109\/15513818309048283","article-title":"Does zonal aganglionosis really exist? Report of a rare variety of Hirschsprung\u2019s disease and review of the literature","volume":"1","author":"Yunis","year":"1983","journal-title":"Pediatr. Pathol"},{"key":"R10-55-20260114","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/S0022-3468(86)80006-9","article-title":"Segmental aganglionosis of the appendix","volume":"21","author":"Anderson","year":"1986","journal-title":"J. Pediatr. Surg"},{"key":"R11-55-20260114","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0022-3468(82)80213-3","article-title":"Double zonal aganglionosis in long segment Hirschsprung\u2019s disease with a \u201cskip area\u201d in transverse colon","volume":"17","author":"de Chadar\u00e9vian","year":"1982","journal-title":"J. Pediatr. 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Surg"}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261221000511?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261221000511?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2021.01.049","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T13:27:50Z","timestamp":1768397270000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2021.01.049"}},"subtitle":["A case report and literature review"],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":11,"journal-issue":{"issue":"C","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2021.01.049","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]}}}