{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T21:22:33Z","timestamp":1793395353555,"version":"4.5.0"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T00:00:00Z","timestamp":1611532800000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>Hirschsprung\u2019s disease (HD) is an uncommon condition in adulthood; the term adult HD denotes diagnosis after the age of ten. Patients suffer from constipation for many years before the diagnosis is established. They have very characteristic radiologic findings; however, the diagnosis is confirmed with full thickness biopsies. We describe the case of a 19-year-old Caucasian female patient from Southeast Missouri with a history of chronic constipation who was referred to the General Surgery Department by her primary care provider (PCP) due to massive colonic and rectal dilation in an abdominal CT scan. After rectal biopsies were performed the diagnosis of Hirschsprung\u2019s disease was confirmed. She was referred to a tertiary center where she underwent a colo-anal pull through procedure. She has been doing well for three years. Diagnosis of this condition can be very challenging, hence the need for clinical suspicion, good quality biopsies and inter-specialty communication among PCPs, gastroenterologists, surgeons and pathologists. Surgery aiming to remove or bypass the aganglionic colonic or rectal segment is the standard of care; quality of life can be significantly improved after surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2021.01.090","type":"journal-article","created":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T18:41:09Z","timestamp":1611859269000},"page":"496-502","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":13,"title":["Adults Hirschsprung\u2019s disease, a call for awareness. A Case Report and review of the literature"],"prefix":"10.1097","volume":"79","author":[{"given":"Cesar O.","family":"Reategui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chester A.","family":"Spears","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina A.","family":"Allred","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-111-20260114","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s11894-007-0026-z","article-title":"Symptomatology, pathophysiology, diagnostic work-up, and treatment of Hirschsprung disease in infancy and childhood","volume":"9","author":"De Lorijn","year":"2007","journal-title":"Curr. Gastroenterol. Rep"},{"key":"R2-111-20260114","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1055\/s-2008-1038625","article-title":"Hirschsprung\u2019s disease, one of the most difficult diagnoses in pediatric surgery: a review of the problems from clinical practice to the bench","volume":"18","author":"Martucciello","year":"2008","journal-title":"Eur. J. Pediatr. Surg"},{"key":"R3-111-20260114","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1136\/gut.27.5.534","article-title":"Hirschprung\u2019s disease and idiopathic mega- colon in adults and adolescents","volume":"27","author":"Barnes","year":"1986","journal-title":"Gut"},{"key":"R4-111-20260114","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.ijsu.2020.10.034","article-title":"The SCARE 2020 guideline: updating consensus surgical CAse REport (SCARE) guidelines","volume":"84","author":"Agha","year":"2020","journal-title":"Int. J. Surg"},{"key":"R5-111-20260114","first-page":"1","article-title":"Stuhltr\u00e4gheit neugeborener in folge von dilatation and hypertrophic des colons","volume":"27","author":"Hirschsprung","year":"1887","journal-title":"Jahrb Kinderh"},{"key":"R6-111-20260114","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/S0025-6196(26)07927-9","article-title":"Congenital megacolon of a man 54 years of age: report of case","volume":"25","author":"Rosin","year":"1950","journal-title":"Proc. Staff Meet. Mayo Clin"},{"key":"R7-111-20260114","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1002\/bjs.1800730930","article-title":"Adult megacolon due to total hypoganglionosis","volume":"73","author":"Pescatori","year":"1986","journal-title":"Br. J. Surg"},{"key":"R8-111-20260114","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/j.1651-2227.1994.tb12955.x","article-title":"An epidemiological study of Hirschsprung\u2019s disease and additional anomalies","volume":"83","author":"Russell","year":"1994","journal-title":"Acta Paediatr"},{"key":"R9-111-20260114","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1007\/s00383-010-2694-2","article-title":"A systematic review and meta-analysis of Hirschsprung\u2019s disease presenting after childhood","volume":"26","author":"Doodnath","year":"2010","journal-title":"Pediatr. Surg. Int"},{"key":"R10-111-20260114","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1148\/radiol.2472070182","article-title":"Hirschsprung disease and hypoganglionosis in adults: radiologic findings and differentiation","volume":"247","author":"Kim","year":"2008","journal-title":"Radiology"},{"key":"R11-111-20260114","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1097\/MPG.0000000000002000","article-title":"Anorectal manometry may reduce the number of rectal suction biopsy procedures needed to diagnose hirschsprung disease","volume":"67","author":"Meinds","year":"2018","journal-title":"J. Pediatr. Gastroenterol. Nutr"},{"key":"R12-111-20260114","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s12519-015-0068-5","article-title":"Rectal biopsy for Hirschsprung\u2019s disease: a review of techniques, pathology, and complications","volume":"12","author":"Muise","year":"2016","journal-title":"World J. Pediatr"},{"key":"R13-111-20260114","first-page":"264","article-title":"Diagnosis of Hirschsprung\u2019s disease with particular emphasis on histopathology. A systematic review of current literature","volume":"9","author":"Szylberg","year":"2014","journal-title":"Prz. Gastroenterol"}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261221000924?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261221000924?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2021.01.090","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T13:29:01Z","timestamp":1768397341000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2021.01.090"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":13,"journal-issue":{"issue":"C","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2021.01.090","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]}}}