{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T10:10:44Z","timestamp":1781172644493,"version":"3.54.1"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T00:00:00Z","timestamp":1627430400000},"content-version":"vor","delay-in-days":208,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,1]]},"abstract":"Abstract<\/jats:title>\n \n Introduction and importance<\/jats:title>\n The parathyroid cancer is sometime only diagnosed after a pathological fracture has occurred, and pathology fracture is often misdiagnosed as a malignancy tumor. The treatment for pathology fracture and multiple bone lesions is not defined.<\/jats:p>\n <\/jats:sec>\n \n Case presentation<\/jats:title>\n We report a 41-year-old case of parathyroid carcinoma in which pathological femoral fracture and brown tumors are the first clinical signs of the disease and that masqueraded as a malignancy tumor. The treatment for the patient was parathyroidectomy and then surgical treatment of the right femur with a locking plate osteosynthesis. Four months post-operative, the patient reported no pain and became capable of walking without a crutch. X-rays showed full bone union at fracture site of right femur, and brown tumors regression seen to be taking place in the upper limb, lower limbs and pelvis.<\/jats:p>\n <\/jats:sec>\n \n Clinical discussion<\/jats:title>\n A brown tumor was diagnosed by a high concentration of blood parathyroid hormone and serum calcium. Despite the lack of clinical guidelines, most authors agreed that parathyroidectomy was the first choice of treatment then orthopaedic treatment. The principles of osteosynthesis of fracture were based on stable osteosynthesis. It was reported that osteolytic lesions caused by brown tumor were recovered when hyperparathyroidism had been treated.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Brown tumor needs to be considered in the differential diagnosis when there are osteolytic lesions and high serum calcium. It is advisable to have a parathyroidectomy and then orthopaedic treatment. Brown tumor with Mirels' score less than 7 scores should be applied a conservative treatment.<\/jats:p>\n <\/jats:sec>\n \n Highlights<\/jats:title>\n <\/jats:sec>","DOI":"10.1016\/j.ijscr.2021.106259","type":"journal-article","created":{"date-parts":[[2021,7,31]],"date-time":"2021-07-31T02:10:34Z","timestamp":1627697434000},"page":"106259","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["The pathology femoral peritrochanteric fracture with multiple brown tumor as a first sign of parathyroid cancer \u2013 A case report"],"prefix":"10.1097","volume":"85","author":[{"given":"Gioi Nang","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luong Van","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-97-20260114","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.21873\/anticanres.15092","article-title":"Pathological fracture of the tibia as a first sign of hyperparathyroidism - a case report and systematic review of the current literature","volume":"41","author":"Keiler","year":"2021","journal-title":"Anticancer Res"},{"key":"R3-97-20260114","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.ijscr.2021.01.002","article-title":"Multiple brown tumors with primary hyperparathyroidism mimicking bone metastases [ ]","volume":"79","author":"Ngo","year":"2021","journal-title":"Int. J. Surg. Case Rep"},{"key":"R4-97-20260114","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.ijsu.2020.10.034","article-title":"The SCARE 2020 guideline: updating consensus Surgical CAse REport (SCARE) guidelines","volume":"84","author":"Agha","year":"2020","journal-title":"Int. J. Surg"},{"key":"R6-97-20260114","doi-asserted-by":"crossref","first-page":"810","DOI":"10.21037\/gs.2019.11.14","article-title":"Multiple bone brown tumor secondary to primary hyperparathyroidism: a case report and literature review","volume":"8","author":"Xu","year":"2019","journal-title":"Gland Surg"},{"key":"R7-97-20260114","doi-asserted-by":"crossref","first-page":"207","DOI":"10.31053\/1853.0605.v78.n2.30679","article-title":"Tibial brown tumor as a presentation of primary hyperparathyroidism","volume":"78","author":"Rueda","year":"2021","journal-title":"Rev. Fac. Cien. Med. Univ. Nac. Cordoba"},{"key":"R8-97-20260114","first-page":"30","article-title":"Parathyroid adenoma with fibrocystic skeletal changes resulting in pathologic fracture of the femur","volume":"21","author":"Steadman","year":"1954","journal-title":"J. Int. Coll. Surg"},{"key":"R9-97-20260114","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1186\/s12891-021-04374-7","article-title":"Osteitis fibrosa cystica mimicking bone tumor, a case report","volume":"22","author":"Nasser","year":"2021","journal-title":"BMC Musculoskelet. Disord"},{"key":"R10-97-20260114","doi-asserted-by":"crossref","first-page":"173","DOI":"10.5371\/hp.2016.28.3.173","article-title":"Pathologic fracture of the femur in brown tumor induced in parathyroid carcinoma: a case report","volume":"28","author":"Park","year":"2016","journal-title":"Hip Pelvis"},{"key":"R11-97-20260114","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s12105-008-0088-8","article-title":"Parathyroid adenoma","volume":"2","author":"Wieneke","year":"2008","journal-title":"Head Neck Pathol"},{"key":"R12-97-20260114","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1007\/s11999-010-1326-4","article-title":"In brief: classifications in brief: Mirels' classification: metastatic disease in long bones and impending pathologic fracture","volume":"468","author":"Jawad","year":"2010","journal-title":"Clin. Orthop. Relat. Res"}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261221007616?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261221007616?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2021.106259","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T13:21:55Z","timestamp":1768396915000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2021.106259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":10,"journal-issue":{"issue":"C","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2021.106259","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]}}}