{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T16:44:34Z","timestamp":1776271474810,"version":"3.50.1"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T00:00:00Z","timestamp":1635379200000},"content-version":"vor","delay-in-days":300,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction and importance<\/jats:title>\n                    <jats:p>Cyclopia is a rare congenital disorder characterized by facial abnormalities. In this condition, the orbits of the eye are not properly divided into two cavities so that they can be seen either as a single eye field or two bilateral fields that are very close to each other. This syndrome affects the embryos that are either aborted or stillborn upon delivery or, at best, die shortly after birth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>This case report is of a 37-week- and 5-day-old female fetus with a birth weight of 2300 g, a height of 43 cm, and a head circumference of 31 cm. She was born to a 44-year-old mother through normal vaginal delivery at Mahzad Hospital, Urmia, Iran. In the physical examination, an eye and a 4-cm proboscis were seen in the middle of the forehead. The newborn also had no nose, and his outer ears were normal. No cleft lip or cleft palate was observed. Unfortunately, the newborn expired 13 h after birth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical discussion<\/jats:title>\n                    <jats:p>Cyclopia leads to a stillbirth since the brain and other parts of the body do not grow normally in fetuses with this disorder. Moreover, it can be diagnosed using ultrasonography while the fetus is growing inside the uterus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Early diagnosis during pregnancy using diagnostic methods and proper management of this abnormality should be emphasized to prevent further harm to the newborn and the mother with this syndrome. Moreover, many of these newborns should be offered early neonatal palliative care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2021.106548","type":"journal-article","created":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T23:37:41Z","timestamp":1635982661000},"page":"106548","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":14,"title":["Cyclopia, a newborn with a single eye, a rare but lethal congenital anomaly"],"prefix":"10.1097","volume":"88","author":[{"given":"Naser","family":"Parizad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Navid","family":"Faraji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amireh","family":"Hassanpour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rasoul","family":"Goli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sajjad","family":"Rostami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akram","family":"Amanollahzadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R4-74-20260114","doi-asserted-by":"crossref","first-page":"177","DOI":"10.4103\/jcn.JCN_23_18","article-title":"Cyclopia-otocephaly-agnathia-synotia-astomia complex: a case report","volume":"7","author":"Singh","year":"2018","journal-title":"J. Clin. Neonatol"},{"key":"R5-74-20260114","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ijpp.2020.12.003","article-title":"A probable case of holoprosencephaly with cyclopia in a full-term fetus from a modern skeletal collection","volume":"1","author":"Palamenghi","year":"2021","journal-title":"Int. J. Paleopathol"},{"key":"R6-74-20260114","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.ijsu.2020.10.034","article-title":"The SCARE 2020 guideline: updating consensus surgical CAse REport (SCARE) guidelines","volume":"1","author":"Agha","year":"2020","journal-title":"Int. J. Surg"},{"key":"R7-74-20260114","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/ajmg.c.31620","article-title":"Syndromes associated with holoprosencephaly","volume":"178","author":"Kruszka","year":"2018","journal-title":"Am. J. Med. Genet. C: Semin. Med. Genet"},{"key":"R8-74-20260114","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/ajmg.c.31615","article-title":"Holoprosencephaly in the genomics era","volume":"178","author":"Roessler","year":"2018","journal-title":"Am. J. Med. Genet. C: Semin. Med. Genet"},{"key":"R9-74-20260114","doi-asserted-by":"crossref","first-page":"e0176440","DOI":"10.1371\/journal.pone.0176440","article-title":"Ethanol itself is a holoprosencephaly-inducing teratogen","volume":"12","author":"Hong","year":"2017","journal-title":"PLoS One"},{"key":"R10-74-20260114","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1002\/ajmg.c.31619","article-title":"Recent advances in understanding inheritance of holoprosencephaly","volume":"178","author":"Dubourg","year":"2018","journal-title":"Am. J. Med. Genet. C: Semin. Med. Genet"},{"key":"R11-74-20260114","first-page":"1","article-title":"The role of genetic mutations on genes PAX2 & PAX6 in cyclopia syndrome","volume":"5","author":"Asadi","year":"2020","journal-title":"Brain"},{"key":"R12-74-20260114","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/ajmg.c.31618","article-title":"Prenatal diagnosis of holoprosencephaly","volume":"178","author":"Kousa","year":"2018","journal-title":"Am. J. Med. Genet. C: Semin. Med. Genet"},{"key":"R14-74-20260114","doi-asserted-by":"crossref","first-page":"19","DOI":"10.4137\/CMPed.S21107","article-title":"Cyclopia: a rare condition with unusual presentation-a case report","volume":"9","author":"Salama","year":"2015","journal-title":"Clin. Med. Insights Pediatr"},{"key":"R15-74-20260114","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.jpainsymman.2020.04.027","article-title":"Redefining palliative care\u2014a new consensus-based definition","volume":"60","author":"Radbruch","year":"2020","journal-title":"J. Pain Symptom Manag"},{"key":"R16-74-20260114","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.21037\/tp-20-141","article-title":"Ethical issues after pre-natal diagnosis","volume":"10","author":"Corno","year":"2021","journal-title":"Transl. 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