{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:24:42Z","timestamp":1792196682681,"version":"4.4.0"},"reference-count":6,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T00:00:00Z","timestamp":1636416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002353","name":"Alexandria University Faculty of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002353","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction and importance:<\/jats:title>\n                    <jats:p>The ectopic parathyroid adenoma is an important cause of refractory and recurrent hyperparathyroidism. The mediastinal location of ectopic parathyroid tissue is reported in up to 20% of cases of ectopic parathyroid adenomas. In around 2% of cases where cervical approach is unfeasible, the mediastinal route imposes a surgical challenge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation:<\/jats:title>\n                    <jats:p>We describe a case of a twenty-five-year-old male patient with manifestations of hyperparathyroidism. Computed tomography of the chest showed an anterior mediastinal mass. Nuclear scintigraphy detected a functioning parathyroid tissue in the mediastinum. The mass was excised en block with the surrounding adipose tissue using a three-port video-assisted thoracoscopic surgery. The patient showed a full symptomatic and laboratory recovery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical discussion:<\/jats:title>\n                    <jats:p>Mediastinal parathyroid glands comprise a unique surgical entity with diagnostic and management difficulties.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Mediastinal parathyroid gland is a rare yet important cause of refractory hypercalcemia. The current localization tools improve the thoracoscopic management of MPAs. VATS can provide access and exposure to ectopic parathyroid adenoma with low morbidity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2021.106598","type":"journal-article","created":{"date-parts":[[2021,11,12]],"date-time":"2021-11-12T02:05:51Z","timestamp":1636682751000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":11,"title":["Ectopic pure mediastinal parathyroid adenoma"],"prefix":"10.1097","volume":"90","author":[{"given":"Hanan M.","family":"Hemead","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed Abdelaziz","family":"Abdellatif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa A.","family":"Abdel Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-3-20260310","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1055\/s-0032-1327628","article-title":"Ectopic parathyroid glands and their anatomical, clinical and surgical implications","volume":"120","author":"Noussios","year":"2012","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"R2-3-20260310","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1308\/003588415X14181254789088","article-title":"Mediastinal parathyroid adenomas and their surgical implications","volume":"97","author":"Hu","year":"2015","journal-title":"Ann. R. Coll. Surg. Engl"},{"key":"R3-3-20260310","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.jamcollsurg.2009.01.032","article-title":"The fallen one: the inferior parathyroid gland that descends into the mediastinum","volume":"208","author":"Callender","year":"2009","journal-title":"J. Am. Coll. Surg"},{"key":"R4-3-20260310","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1002\/bjs5.50207","article-title":"Video-assisted thoracoscopic surgery for ectopic mediastinal parathyroid adenoma","volume":"3","author":"Isaacs","year":"2019","journal-title":"BJS Open"},{"key":"R5-3-20260310","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.ijsu.2020.10.034","article-title":"The SCARE 2020 guideline: updating consensus surgical CAse REport (SCARE) guidelines","volume":"84","author":"Agha","year":"2020","journal-title":"Int. J. Surg"},{"key":"R6-3-20260310","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1097\/00129689-200208000-00021","article-title":"Thoracoscopy: the preferred method for excision of mediastinal parathyroids","volume":"12","author":"Kumar","year":"2002","journal-title":"Surg. Laparosc. Endosc. Percutan. Tech"}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261221011007?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261221011007?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2021.106598","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T10:00:31Z","timestamp":1773136831000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2021.106598"}},"subtitle":["A case report"],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":6,"journal-issue":{"issue":"C","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2021.106598","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]}}}