{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T07:52:01Z","timestamp":1773215521500,"version":"3.50.1"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,19]],"date-time":"2021-12-19T00:00:00Z","timestamp":1639872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction and importance:<\/jats:title>\n                    <jats:p>There is no clear consensus on a specific treatment for esophageal perforation. The surgical approach is deemed necessary for local severe infection and pleural contamination requiring debridement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Presentations of case:<\/jats:title>\n                    <jats:p>We have reported herein the case of a patient with esophageal perforation with severe mediastinal and thoracic abscess after endoscopic balloon dilation for stenosis due to endoscopic submucosal dissection and chemoradiotherapy. A surgical approach with primary closure was performed, but not found effective; while conservative treatment with mediastinal drainage via posterior neck and recovery of nutritional status was found to be effective. For the recovery of nutritional status, enteral nutrition was assessed using a polymeric formula through a percutaneous endoscopic gastrojejunostomy tube.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>Esophageal perforation is a life-threatening condition. Iatrogenic injuries are the frequent cause of esophageal perforation. For esophageal perforation, not only surgical interventions but also conservative treatments including various endoscopic approaches have been performed. If the inflammation is not localized, surgical intervention is often needed; however, if the patient's general condition is stable, conservative treatment with drainage, antibiotics, and nutritional management may be considered, even in cases of esophageal perforation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Esophageal perforation with a large perforation site with widespread inflammation can be improved with proper thoracic and mediastinal drainage and adequate nutrition support if the patient's condition is mild.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2021.106728","type":"journal-article","created":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T21:36:38Z","timestamp":1640295398000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Difficult to treat esophageal perforation after endoscopic balloon dilation for stenosis due to endoscopic submucosal dissection followed by chemoradiotherapy"],"prefix":"10.1097","volume":"90","author":[{"given":"Takumi","family":"Kitahama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenjiro","family":"Ishii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoma","family":"Haneda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masazumi","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuhei","family":"Mayanagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Tsubosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-78-20260310","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10388-018-0641-9","article-title":"Esophageal cancer practice guidelines 2017 edited by the Japan esophageal society: part 1","volume":"16","author":"Kitagawa","year":"2019","journal-title":"Esophagus"},{"key":"R2-78-20260310","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s10388-018-0642-8","article-title":"Esophageal cancer practice guidelines 2017 edited by the Japan esophageal society: part 2","volume":"16","author":"Kitagawa","year":"2019","journal-title":"Esophagus"},{"key":"R3-78-20260310","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.gie.2009.04.044","article-title":"Long-term outcomes of endoscopic submucosal dissection for superficial esophageal squamous cell neoplasms","volume":"70","author":"Ono","year":"2009","journal-title":"Gastrointest. Endosc"},{"key":"R4-78-20260310","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.ijrobp.2010.06.033","article-title":"Phase II study of chemoradiotherapy with 5-fluorouracil and cisplatin for stage II-III esophageal squamous cell carcinoma: JCOG trial (JCOG 9906)","volume":"81","author":"Kato","year":"2011","journal-title":"Int. J. Radiat. Oncol. Biol. Phys"},{"key":"R5-78-20260310","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/j.gie.2011.07.070","article-title":"The efficacy of endoscopic triamcinolone injection for the prevention of esophageal stricture after endoscopic submucosal dissection","volume":"74","author":"Hashimoto","year":"2011","journal-title":"Gastrointest. Endosc"},{"key":"R6-78-20260310","doi-asserted-by":"crossref","first-page":"2953","DOI":"10.1007\/s00464-014-4028-2","article-title":"Complications of endoscopic dilation for esophageal stenosis after endoscopic submucosal dissection of superficial esophageal cancer","volume":"29","author":"Kishida","year":"2015","journal-title":"Surg. Endosc"},{"key":"R7-78-20260310","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1055\/s-0030-1256109","article-title":"Risk of perforation during dilation for esophageal strictures after endoscopic resection in patients with early squamous cell carcinoma","volume":"43","author":"Takahashi","year":"2011","journal-title":"Endoscopy"},{"key":"R8-78-20260310","doi-asserted-by":"crossref","first-page":"2724","DOI":"10.21037\/jtd-19-4096","article-title":"The insidious presentation and challenging management of esophageal perforation following diagnostic and therapeutic interventions","volume":"12","author":"Lampridis","year":"2020","journal-title":"J. Thorac. Dis"},{"key":"R9-78-20260310","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1080\/00365521.2019.1575464","article-title":"Outcome after iatrogenic esophageal perforation","volume":"54","author":"Hauge","year":"2019","journal-title":"Scand. J. Gastroenterol"},{"key":"R10-78-20260310","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1177\/0884533609358997","article-title":"Understanding the role of nutrition and wound healing","volume":"25","author":"Stechmiller","year":"2010","journal-title":"Nutr. Clin. Pract"},{"key":"R11-78-20260310","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.ijsu.2020.10.034","article-title":"The SCARE 2020 guideline: updating consensus Surgical CAse REport (SCARE) guidelines","volume":"84","author":"Agha","year":"2020","journal-title":"Int J Surg"},{"key":"R12-78-20260310","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/j.athoracsur.2003.08.037","article-title":"Evolving options in the management of esophageal perforation","volume":"77","author":"Brinster","year":"2004","journal-title":"Ann. Thorac. Surg"},{"key":"R13-78-20260310","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1001\/archinte.1992.00400160069013","article-title":"Esophageal perforation: a reassessment of the criteria for choosing medical or surgical therapy","volume":"152","author":"Shaffer","year":"1992","journal-title":"Arch. Intern. Med"},{"key":"R14-78-20260310","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1007\/s00268-013-1951-7","article-title":"Current treatment and outcome of esophageal perforations in adults: systematic review and meta-analysis of 75 studies","volume":"37","author":"Biancari","year":"2013","journal-title":"World J. Surg"},{"key":"R15-78-20260310","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1007\/s12328-017-0808-2","article-title":"Delayed perforation after endoscopic submucosal dissection treated successfully by temporary stent placement","volume":"11","author":"Omae","year":"2018","journal-title":"Clin. J. Gastroenterol"},{"key":"R16-78-20260310","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1007\/s10388-014-0462-4","article-title":"Utility of the over-the-scope-clip system for treating a large esophageal perforation","volume":"12","author":"Ono","year":"2015","journal-title":"Esophagus"},{"key":"R17-78-20260310","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1053\/jcgh.2003.50007","article-title":"Endoscopic clip application as an adjunct to closure of mature esophageal perforation with fistulae","volume":"1","author":"Raymer","year":"2003","journal-title":"Clin. Gastroenterol. Hepatol"},{"key":"R18-78-20260310","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1007\/s12328-017-0738-z","article-title":"Endoscopic tissue shielding for esophageal perforation caused by endoscopic resection","volume":"10","author":"Takahashi","year":"2017","journal-title":"ClinJ. Gastroenterol"},{"key":"R19-78-20260310","doi-asserted-by":"crossref","first-page":"363","DOI":"10.5761\/atcs.cr.15-00305","article-title":"Endoscopic vacuum-assisted closure (E-VAC) treatment in a patient with delayed anastomotic perforation following a perforated gastric conduit repair after an Ivor-Lewis esophagectomy","volume":"22","author":"Youn","year":"2016","journal-title":"Ann. Thorac. Cardiovasc. Surg"},{"key":"R20-78-20260310","doi-asserted-by":"crossref","first-page":"448","DOI":"10.21037\/atm.2016.11.29","article-title":"Successful surgical treatment of a complicated esophageal perforation, by use of primary closure and lung parenchyma reinforcement","volume":"4","author":"Schizas","year":"2016","journal-title":"Ann. Transl. Med"},{"key":"R21-78-20260310","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/0002-9610(86)90144-3","article-title":"Options in the management of perforations of the esophagus","volume":"152","author":"Brewer","year":"1986","journal-title":"Am. J. Surg"},{"key":"R22-78-20260310","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1007\/s12328-015-0588-5","article-title":"EUS-FNA can be an effective procedure for the transesophageal drainage of a patient with intra-peritoneal abscess","volume":"8","author":"Hara","year":"2015","journal-title":"Clin. J. Gastroenterol"},{"key":"R23-78-20260310","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1097\/01.prs.0000225432.17501.6c","article-title":"Nutrition and wound healing","volume":"117","author":"Arnold","year":"2006","journal-title":"Plast. Reconstr. Surg"},{"key":"R24-78-20260310","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1177\/0148607115621863","article-title":"Guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient","volume":"40","author":"McClave","year":"2016","journal-title":"J. Parenter Enteral Nutr"},{"key":"R25-78-20260310","first-page":"840","article-title":"Efficacy and safety evaluation of a novel enteral nutrition formula (ENG-J) in postoperative patients who underwent esophagectomy or Total gastrectomy for cancer \u2014a multicenter randomized open-label, unblinded parallel comparative study\u2014","volume":"39","author":"Fukushima","year":"2014","journal-title":"J. Jpn. College Surg"},{"key":"R26-78-20260310","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S1052-3359(03)00030-9","article-title":"Tracheoesophageal fistula","volume":"13","author":"Reed","year":"2003","journal-title":"Chest Surg. Clin. N. Am"}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221026122101230X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221026122101230X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2021.106728","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T10:01:09Z","timestamp":1773136869000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2021.106728"}},"subtitle":["A case report"],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":26,"journal-issue":{"issue":"C","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2021.106728","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]}}}