{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T18:40:34Z","timestamp":1787683234103,"version":"build-2784847793"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,26]],"date-time":"2022-02-26T00:00:00Z","timestamp":1645833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction and importance:<\/jats:title>\n                    <jats:p>Lipoblastoma-like tumors are rare tumors that can be confused with lipoblastomas and liposarcomas but have distinct characteristics. This tumor has previously been identified in the vulva of females, and recently in isolated cases of young males. Given its rarity, we present an instance of this tumor in an older man, demonstrating that this pathology is not limited to a specific age or sex, and surgeons and pathologists must be aware of it in their differential.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation:<\/jats:title>\n                    <jats:p>A 58-year-old male presented for evaluation of an enlarging mass in his right gluteal cleft. Prior to referral for surgical evaluation, the patient underwent an ultrasound-guided biopsy of the mass. Histologically, the tumor was a low-grade cellular spindle cell neoplasm in a fibrous to myxoid stroma. Immunohistochemical and molecular workup ruled out several malignant mesenchymal neoplasms, including myxoid liposarcoma, dedifferentiated liposarcoma, melanoma, low-grade fibromyxoid sarcoma, and sarcomatoid carcinoma. The patient initially declined surgery, but the mass continued to grow, and excision was chosen given the uncertain pathology. The tumor was resected with negative margins and histologically characterized as a \u201clipoblastoma-like lesion\u201d, with features of a myxoid liposarcoma and spindle cell lipoma. Seven months post-resection, there were no signs of recurrence or metastasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical discussion:<\/jats:title>\n                    <jats:p>Despite radiologic and pathologic similarities to malignant lipomatous tumors, lipoblastoma-like tumors are benign and have a good prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Clinicians should be aware of this entity despite its rarity as resection with negative margins is curative and may be needed to rule out more aggressive tumors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2022.106889","type":"journal-article","created":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T02:08:38Z","timestamp":1646100518000},"page":"106889","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["When is a lipoma not a lipoma? Case report presenting a lipoblastoma-like tumor of the gluteal cleft in an older gentleman with literature review"],"prefix":"10.1097","volume":"92","author":[{"given":"Celeste G.","family":"Yergin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan M.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-66-20260310","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1046\/j.1365-2559.2002.01409.x","article-title":"Lipoblastoma-like tumour of the vulva: report of three cases of a distinctive mesenchymal neoplasm of adipocytic differentiation","volume":"40","author":"Lae","year":"2002","journal-title":"Histopathology"},{"key":"R2-66-20260310","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1038\/s41379-018-0102-y","article-title":"Lipoblastoma-like tumor of the vulva: a clinicopathologic, immunohistochemical, fluorescence in situ hybridization and genomic copy number profiling study of seven cases","volume":"31","author":"Schoolmeester","year":"2018","journal-title":"Mod. Pathol"},{"key":"R3-66-20260310","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1053\/j.semdp.2019.02.008","article-title":"A contemporary review of myxoid adipocytic tumors","volume":"36","author":"Creytens","year":"2019","journal-title":"Semin. Diagn. Pathol"},{"key":"R4-66-20260310","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1097\/PAS.0000000000000448","article-title":"Lipoblastoma-like tumor of the vulva: further characterization in 8 new cases","volume":"39","author":"Mirkovic","year":"2015","journal-title":"Am. J. Surg. Pathol"},{"key":"R5-66-20260310","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1111\/his.14020","article-title":"A lipoblastoma-like tumour of the paratesticular region - male counterpart of lipoblastoma-like tumour of the vulva","volume":"76","author":"Droop","year":"2020","journal-title":"Histopathology"},{"key":"R6-66-20260310","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1007\/s00428-020-02883-9","article-title":"Lipoblastoma-like tumor of the spermatic cord: case report and review of the literature","volume":"478","author":"Gambarotti","year":"2021","journal-title":"Virchows Arch. Int. J. Pathol"},{"key":"R9-66-20260310","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1477-7819-7-42","article-title":"Myxoid liposarcoma: a rare soft-tissue tumor with a misleading benign appearance","volume":"7","author":"Loubignac","year":"2009","journal-title":"World J. Surg. Oncol"},{"key":"R10-66-20260310","first-page":"223","article-title":"Benign lipoblastomalike tumor of the vulva: report of a case affecting a young patient","volume":"52","author":"Atallah","year":"2007","journal-title":"J. Reprod. Med"},{"key":"R11-66-20260310","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.ijsu.2020.10.034","article-title":"The SCARE 2020 guideline: updating consensus Surgical CAse REport (SCARE) guidelines","volume":"84","author":"Agha","year":"2020","journal-title":"Int. J. Surg. Lond. Engl"},{"key":"R12-66-20260310","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1097\/PDM.0b013e3182107eb9","article-title":"DDIT3 gene break-apart as a molecular marker for diagnosis of myxoid liposarcoma-assay validation and clinical experience","volume":"20","author":"Narendra","year":"2011","journal-title":"Diagn. Mol. Pathol. Am. J. Surg. Pathol. Part B"},{"key":"R13-66-20260310","doi-asserted-by":"crossref","first-page":"374","DOI":"10.2214\/AJR.14.12888","article-title":"Myxoid soft-tissue neoplasms: comprehensive update of the taxonomy and MRI features","volume":"204","author":"Baheti","year":"2015","journal-title":"Am. J. Roentgenol"},{"key":"R14-66-20260310","first-page":"430","article-title":"The rapidly expanding group of RB1-deleted soft tissue tumors: an updated review","volume":"11","author":"Libbrecht","year":"2021","journal-title":"Diagn. Basel Switz"},{"key":"R15-66-20260310","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1038\/modpathol.2017.94","article-title":"Expanded molecular profiling of myxofibrosarcoma reveals potentially actionable targets","volume":"30","author":"Heitzer","year":"2017","journal-title":"Mod. 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