{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T04:12:50Z","timestamp":1777349570589,"version":"3.51.4"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,27]],"date-time":"2022-02-27T00:00:00Z","timestamp":1645920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction and importance:<\/jats:title>\n                    <jats:p>In patients with congenital factor VII (FVII) deficiency, perioperative bleeding events are concern, so recombinant activated factor VII (rFVIIa) is favorably used, but the optimal dosage regimen has not clearly established. We report management of a patient with congenital FVII deficiency who underwent laparoscopic cholecystectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation:<\/jats:title>\n                    <jats:p>A 70-year-male with congenital FVII deficiency was diagnosed as acute cholecystitis, so we planned laparoscopic cholecystectomy. FVII activity and prothrombin time international normalized ratio (PT-INR) were intraoperatively monitored as scheduled. At the start of surgery, FVII activity was 3.1% (75\u2013130%) and PT-INR was 3.37 (0.8\u20131.2), so 1 mg of rFVIIa was administered. Both of these values then improved to 325.0% and 0.73, respectively. Laparoscopic cholecystectomy was successfully completed without unexpected bleeding or oozing. When FVII activity and PT-INR was re-checked 6 h after the first administration of rFVIIa, these values were 23.9% and 1.53, respectively. Additional 1 mg of rFVIIa was used only once after the operation. The patient was discharged on the sixth day after surgery without postoperative complication.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical discussion:<\/jats:title>\n                    <jats:p>In this case, rFVIIa was used just twice and there were no bleeding events during the perioperative period. Previous reports suggested using 15\u201330 \u03bcg\/kg of rFVIIa before surgery and subsequent every 4\u20136 h in the first 24 h, then increasing the interval to 8\u201312 h. It is necessary to evaluate optimal dose of rFVIIa based on the risk and surgical invasiveness for each case.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our patient with congenital FVII deficiency uneventfully underwent laparoscopic cholecystectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2022.106892","type":"journal-article","created":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T02:07:59Z","timestamp":1646100479000},"page":"106892","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Perioperative management for patient with congenital factor VII deficiency who underwent laparoscopic cholecystectomy"],"prefix":"10.1097","volume":"92","author":[{"given":"Tomohiro","family":"Yoshimura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Hayami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manabu","family":"Kawai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken-ichi","family":"Okada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Ueno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Yamaue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-68-20260310","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1182\/blood-2014-08-532820","article-title":"Rare bleeding disorders: diagnosis and treatment","volume":"125","author":"Palla","year":"2015","journal-title":"Blood"},{"key":"R2-68-20260310","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1111\/j.1365-2516.2008.01844.x","article-title":"International Registry on Congenital Factor VIID. Factor VII deficiency: defining the clinical picture and optimizing therapeutic options","volume":"14","author":"Lapecorella","year":"2008","journal-title":"Haemophilia"},{"key":"R3-68-20260310","first-page":"1","article-title":"Surgery in patients with congenital factor VII deficiency - a single center study","volume":"90","author":"Szczepanik","year":"2018","journal-title":"Pol. Przegl. Chir"},{"key":"R5-68-20260310","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.ijsu.2020.10.034","article-title":"The SCARE 2020 guideline: updating consensus Surgical CAse REport (SCARE) guidelines","volume":"84","author":"Agha","year":"2020","journal-title":"Int. J. Surg"},{"key":"R6-68-20260310","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s40981-016-0059-0","article-title":"Anesthetic management of a patient with factor VII deficiency undergoing laparoscopic colectomy: a case report","volume":"2","author":"Yoshida","year":"2016","journal-title":"JA Clin. Rep"},{"key":"R7-68-20260310","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1111\/j.1538-7836.2011.04291.x","article-title":"French Study Group of Factor VIID. A retrospective analysis of 157 surgical procedures performed without replacement therapy in 83 unrelated factor VII-deficient patients","volume":"9","author":"Benlakhal","year":"2011","journal-title":"J. Thromb. Haemost"},{"key":"R8-68-20260310","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1182\/blood-2018-06-820738","article-title":"Treatment of rare factor deficiencies other than hemophilia","volume":"133","author":"Menegatti","year":"2019","journal-title":"Blood"},{"key":"R9-68-20260310","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1111\/j.1365-2516.2011.02596.x","article-title":"rFVIIa administered by continuous infusion during surgery in patients with severe congenital FVII deficiency","volume":"17","author":"Tran","year":"2011","journal-title":"Haemophilia"},{"key":"R10-68-20260310","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1365-2516.2006.01180.x","article-title":"Congenital factor VII deficiency: therapy with recombinant activated factor VII - a critical appraisal","volume":"12","author":"Mariani","year":"2006","journal-title":"Haemophilia"},{"key":"R11-68-20260310","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1056\/NEJMoa1006221","article-title":"Safety of recombinant activated factor VII in randomized clinical trials","volume":"363","author":"Levi","year":"2010","journal-title":"N. Engl. J. Med"}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261222001389?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261222001389?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2022.106892","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T10:03:35Z","timestamp":1773137015000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2022.106892"}},"subtitle":["Case report"],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":10,"journal-issue":{"issue":"C","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2022.106892","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]}}}