{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T15:42:11Z","timestamp":1772638931576,"version":"3.50.1"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T00:00:00Z","timestamp":1646697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction and importance:<\/jats:title>\n                    <jats:p>The neoplasms of the testis are sporadic tumors among men. Furthermore, the rarest subset of these is neoplasms belonging to the stromal tumors of the sex cord. Leydig cell tumors are the most common form among the testicular stromal tumors. In our case, the underlying risk factor associated with the development of Leydig cell tumors was cryptorchidism. While mostly unilateral, cases of bilateral cryptorchidism may be present and have been rarely reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation:<\/jats:title>\n                    <jats:p>We report a 36-year-old gentleman who presented to us with the inability to carry off intercourse without difficulty attaining erection on stimulation for the past two years. He had a history of left undescended testis since birth, for which he underwent left orchidopexy 20 years ago. An ultrasound of the pelvis showed an oval hypoechoic-shaped heterogeneous mass in the right mid-inguinal canal. Relevant blood investigations showed a deranged hormonal profile. He then underwent an uneventful right radical orchiectomy, histopathology of which was consistent with Leydig cell tumor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical discussion:<\/jats:title>\n                    <jats:p>LCT with a history of bilateral cryptorchidism has rarely been reported. This case highlights its clinical presentation, management, and further follow-up in such patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Bilateral congenital cryptorchidism may be associated with Leydig cell tumor years later in life hence long-term follow-up is required for these patients. The clinical presentation of these tumors may vary among individuals. Any change in physical appearance, hormonal assay, and imaging studies should promptly be followed for possible surgical resection and close monitoring.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2022.106923","type":"journal-article","created":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T02:23:51Z","timestamp":1646792631000},"page":"106923","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Bilateral congenital cryptorchidism and unilateral Leydig cell tumor in an adult presenting with gynecomastia and primary infertility"],"prefix":"10.1097","volume":"93","author":[{"given":"Mirza Rameez","family":"Samar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saqib Raza","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Tariq","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salman Muhammad","family":"Soomar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehwish","family":"Shahzadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-35-20260304","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1590\/s1677-5538.ibju.2018.0720","article-title":"Malignant Leydig cell tumor in a 91-year-old man: case report","volume":"45","author":"Justo","year":"2019","journal-title":"Int.Braz. J. Urol"},{"key":"R2-35-20260304","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1093\/humrep\/dez083","article-title":"Clinical presentation, management and follow-up of 83 patients with Leydig cell tumors of the testis: a prospective case-cohort study","volume":"34","author":"Pozza","year":"2019","journal-title":"Hum. Reprod"},{"key":"R3-35-20260304","first-page":"577","article-title":"Precocious pseudo-puberty with testicular enlargement: two cases of Leydig cell tumor with different histopathological results","volume":"12","author":"Trahmono","year":"2020","journal-title":"Res. Rep. Urol"},{"key":"R5-35-20260304","first-page":"164","article-title":"Leydig cell hyperplasia revealed by gynecomastia","volume":"10","author":"Tazi","year":"2008","journal-title":"Rev.Urol"},{"key":"R7-35-20260304","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1111\/andr.12964","article-title":"Fertility potential in adult men treated for uncorrected bilateral cryptorchidism: a systematic literature review and analysis of case reports","volume":"9","author":"Muncey","year":"2021","journal-title":"Andrology"},{"key":"R9-35-20260304","first-page":"105","article-title":"A rare case report of undescended testis: both on one side","volume":"17","author":"Tasa","year":"2020","journal-title":"Urol. 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Pathol"},{"key":"R16-35-20260304","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s00345-017-2151-0","article-title":"Testicle-sparing surgery versus radical orchiectomy in the management of Leydig cell tumors: results from a multicenter study","volume":"36","author":"Laclergerie","year":"2018","journal-title":"World J. 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