{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T11:51:01Z","timestamp":1781524261776,"version":"3.54.1"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T00:00:00Z","timestamp":1649635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Primary signet-ring cell carcinoma (PSRCC) of the uterine cervix mostly occurs due to the metastasis from the primary organ, such as the gastrointestinal tract or breast. This case describes the cervical PSRCC and its management as a rare case.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Presentation of case:<\/jats:title>\n                    <jats:p>The 39-year-old female came to undergo cancer screening. Visual Inspection with Acetic Acid (VIA) examination result was negative with the feature of severe cervicitis, and then the patient was given Trichloroacetic Acid (TCA) procedure. Three weeks after TCA's procedure, speculum examination found morphological features of cervix malignancy. Cervical biopsy examination showed mucinous adenocarcinoma, signet ring cell variant, with lymphovascular invasion. Endometrial microcurettage specimen do not contain tumor mass.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>The risk factor for cervical cancer in this patient was early sexual intercourse. We suggested stage IB2 cervical cancer because the tumor size was 2 cm until 4 cm, there was no spreading to nearby lymph nodes nor distant sites. Then patient had performed a radical hysterectomy procedure with ovary transposition and a series of radiation therapy. The patient was in good condition and no metastases were found in the imaging study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The treatment of PSRCC of the uterine cervix is challenging. It was established from intraoperative findings, histopathology, and immunohistochemistry examination. The radical hysterectomy adjunct to radiation was effective in the treatment of the PSRCC of the uterine cervix.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2022.107083","type":"journal-article","created":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T11:48:53Z","timestamp":1649850533000},"page":"107083","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Could combination of radical hysterectomy and radiation effective in the treatment of primary cervical signet ring cell carcinoma?"],"prefix":"10.1097","volume":"94","author":[{"given":"Gatot","family":"Purwoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kartiwa Hadi","family":"Nuryanto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taufik Agung","family":"Wibowo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tantri","family":"Hellyanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny Maesadatu","family":"Syaharutsa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelli","family":"Julianti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-86-20260304","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.tjog.2018.10.017","article-title":"Primary signet ring cell carcinoma of the cervix: a case report with review of the literature","volume":"57","author":"Wang","year":"2018","journal-title":"Taiwan J. Obstet. Gynecol"},{"key":"R4-86-20260304","doi-asserted-by":"crossref","first-page":"720","DOI":"10.21147\/j.issn.1000-9604.2020.06.05","article-title":"Cervical cancer: epidemiology, risk factors and screening","volume":"32","author":"Zhang","year":"2020","journal-title":"Chin. J. Cancer Res"},{"key":"R5-86-20260304","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/ijgo.12611","article-title":"Cancer of the cervix uteri","volume":"143","author":"Bhatla","year":"2018","journal-title":"Int. J. Gynecol. Obstet"},{"key":"R6-86-20260304","first-page":"559","article-title":"Primary signet ring cell carcinoma of the uterine cervix","volume":"90","author":"Moll","year":"1990","journal-title":"Prim. Signet Ring Cell Carcinoma Uterine Cervix"},{"key":"R7-86-20260304","first-page":"374","article-title":"Primary signet ring cell carcinoma of the uterine cervix: a clinicopathologic study of two cases with review of the literature","volume":"8","author":"Hasnawi","year":"2002","journal-title":"Int. J. Gynecol. Cancer"},{"key":"R8-86-20260304","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.ijsu.2020.10.034","article-title":"The SCARE 2020 guideline: updating consensus surgical CAse REport (SCARE) guidelines","volume":"84","author":"Agha","year":"2020","journal-title":"Int. J. Surg"},{"key":"R9-86-20260304","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s13691-019-00375-5","article-title":"Primary signet ring cell carcinoma of uterine cervix and related disease: two case reports and a review","volume":"8","author":"Hamada","year":"2019","journal-title":"Int. Cancer Conf. 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