{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:02:23Z","timestamp":1792789343735,"version":"4.5.0"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction and importance:<\/jats:title>\n                    <jats:p>Honey has been recorded as having healing properties at a low cost. Many studies have been conducted related to Manuka honey, but studies about Indonesian randu honey are still limited. We report the use of Indonesian randu honey as a wound dressing on non-pressure chronic skin ulcers in uncontrolled T2DM patient.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation:<\/jats:title>\n                    <jats:p>A 54-year-old man with uncontrolled T2DM came with an unrecovered wound. A thorough inspection revealed several exposed bones, tendons, muscles, and meniscus in the left lower leg region. It was supposed to be amputated, but he declined. He received insulin, debridement, STSG, and a combination of Indonesian randu honey dressing and VAC on the exposed wound before and after the debridement and STSG. There was skin graft lysis, and we intended to do another surgery, but he preferred to be an outpatient. As an outpatient, he received honey wound dressing and insulin. After 1.5 years, the wound was fully closed, and he could walk with the help of a walking stick.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical discussion:<\/jats:title>\n                    <jats:p>Treatment for multiple exposed bones, tendons, and muscles in uncontrolled T2DM patient are complex. Studies reported that Indonesian honey could provide an antibacterial effect, cost-efficiency, speed up wound healing with no side effects, and no physical-chemical properties differences compared to Manuka honey.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Using Indonesian randu honey as wound dressing could stimulate wound healing with no side effects in chronic wounds with uncontrolled T2DM that were supposed to be amputated. However, it took several months for the wound to fully close.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2022.107140","type":"journal-article","created":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T08:10:41Z","timestamp":1651651841000},"page":"107140","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["The use of Indonesian randu honey for chronic wounds in a patient with uncontrolled type 2 diabetes mellitus"],"prefix":"10.1097","volume":"95","author":[{"given":"Siti Isya","family":"Wahdini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Rosadi","family":"Seswandhana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurardhilah","family":"Vityadewi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rianto Noviady","family":"Ramli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gita Christy","family":"Gabriela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ishandono","family":"Dachlan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-10-20260304","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1177\/0022034509359125","article-title":"Factors affecting wound healing","volume":"89","author":"Guo","year":"2010","journal-title":"J. Dent. Res"},{"key":"R2-10-20260304","doi-asserted-by":"crossref","first-page":"22","DOI":"10.7603\/s40681-015-0022-9","article-title":"Wound dressings: a review","volume":"5","author":"Dhivya","year":"2015","journal-title":"Biomedicine (Taipei"},{"key":"R3-10-20260304","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1100\/tsw.2011.78","article-title":"Honey for wound healing, ulcers, and burns: data supporting its use in clinical practice","volume":"11","author":"Al-Waili","year":"2011","journal-title":"Sci. World J"},{"key":"R4-10-20260304","doi-asserted-by":"crossref","first-page":"46","DOI":"10.3390\/bioengineering5020046","article-title":"Honey-based templates in wound healing and tissue engineering","volume":"5","author":"Minden-Birkenmaier","year":"2018","journal-title":"Bioengineering (Basel"},{"key":"R5-10-20260304","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1089\/wound.2019.0946","article-title":"Human wounds and its burden: an updated compendium of estimates","volume":"8","author":"Sen","year":"2019","journal-title":"Adv.Wound Care"},{"key":"R6-10-20260304","first-page":"67","article-title":"Antibacterial potency of Indonesian randu honey against Staphylococcus sp","volume":"16","author":"Diyantoro","year":"2020","journal-title":"Malays.J.Med.Health Sci"},{"key":"R7-10-20260304","first-page":"177","article-title":"Antibacterial activity of Indonesian local honey against strains of P. aeruginosa, S. aureus and MRSA","volume":"1","author":"ADK","year":"2012","journal-title":"Jurnal Plastik Rekonstruksi (JPR"},{"key":"R8-10-20260304","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.ijsu.2020.10.034","article-title":"The SCARE 2020 guideline: updating consensus Surgical CAse REport (SCARE) guidelines","volume":"84","author":"Agha","year":"2020","journal-title":"Int. J. Surg"},{"key":"R9-10-20260304","doi-asserted-by":"crossref","first-page":"62","DOI":"10.13181\/mji.v27i1.1457","article-title":"Honey clinically stimulates granulation and epithelialization in chronic wounds: a report of two cases","volume":"27","author":"Kefani","year":"2018","journal-title":"Med.J.Indones"},{"key":"R10-10-20260304","doi-asserted-by":"crossref","first-page":"100","DOI":"10.17795\/jjnpp-9487","article-title":"Evidence for clinical use of honey in wound healing as an antibacterial, anti-inflammatory anti-oxidant and anti-viral agent: a review","volume":"8","author":"Yaghoobi","year":"2013","journal-title":"Jundishapur J.Nat.Pharm.Prod"},{"key":"R11-10-20260304","first-page":"28","article-title":"Reintroducing honey in the management of wounds and ulcers - theory and practice","volume":"48","author":"Molan","year":"2002","journal-title":"Ostomy Wound Manag"},{"key":"R12-10-20260304","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1515\/biol-2021-0084","article-title":"Honey in wound healing: an updated review","volume":"16","author":"Tashkandi","year":"2021","journal-title":"Open Life Sci"},{"key":"R13-10-20260304","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/j.1742-481X.2010.00717.x","article-title":"Honey compared with silver sulphadiazine in treating superficial partial-thickness burns","volume":"7","author":"Malik","year":"2010","journal-title":"Int. Wound J"},{"key":"R14-10-20260304","doi-asserted-by":"crossref","first-page":"4784","DOI":"10.3390\/molecules26164784","article-title":"Role of honey in advanced wound care","volume":"26","author":"Scepankova","year":"2021","journal-title":"Molecules"},{"key":"R15-10-20260304","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/S2221-1691(11)60016-6","article-title":"Honey: its medicinal property and antibacterial activity","volume":"1","author":"Mandal","year":"2011","journal-title":"Asian Pac. J. Trop. Biomed"},{"key":"R17-10-20260304","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/dmrr.2243","article-title":"Negative pressure therapy: theory and practice","volume":"28","author":"Schintler","year":"2012","journal-title":"Diabetes Metab.Res.Rev"},{"key":"R18-10-20260304","first-page":"117","article-title":"The simplest modified vacuum assisted closure to treat chronic wound: serial case report","volume":"2","author":"Mahandaru","year":"2021","journal-title":"Jurnal Plastik Rekonstruksi"},{"key":"R19-10-20260304","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ijscr.2020.03.034","article-title":"A case series of negative pressure wound therapy as a promising treatment in patients with burn injury","volume":"69","author":"Seswandhana","year":"2020","journal-title":"Int. J. Surg. Case Rep"}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261222003868?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261222003868?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2022.107140","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T10:04:01Z","timestamp":1772618641000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2022.107140"}},"subtitle":["A case report"],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":18,"journal-issue":{"issue":"C","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2022.107140","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]}}}