{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T15:47:24Z","timestamp":1772639244068,"version":"3.50.1"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T00:00:00Z","timestamp":1651968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Thymoma is a rare neoplasm, which may be associated with autoimmune disorders, the occurrence of hyperthyroidism in the patients with thymoma is rare.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical presentation:<\/jats:title>\n                    <jats:p>Here we present an extremely rare case of a 56-year-old female patient who was discovered to have malignant thymoma with associated myasthenia gravis and hyperthyroidism due to toxic multinodular goiter. Our patient started to complain of difficulty breathing and swallowing, Chest CT scan was done and revealed an anterior mediastinal mass, measures about 4.1 \u00d7 3.1 \u00d7 2.2 cm with enlarged lymph node mostly representing thymoma.<\/jats:p>\n                    <jats:p>Complete thymectomy was performed via uniportal video-assisted thoracoscopic surgery, and the patient's postoperative recovery was uneventful. Microscopic histopathology findings corresponded to thymoma type B1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The coexistence of thymoma, MG and toxic multinodular goiter is extremely rare. MG should always be suspected in a patient with thymoma. VATS thymectomy has been increasingly used to treat thymoma as it has several advantages over open surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2022.107183","type":"journal-article","created":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T04:33:28Z","timestamp":1652243608000},"page":"107183","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["A case of uniportal VATS thymectomy for Thymoma associated with myasthenia gravis and toxic multinodular goiter"],"prefix":"10.1097","volume":"95","author":[{"given":"Osama N.","family":"Dukmak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruba","family":"Dweik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadeen","family":"Hashlamoun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahaf","family":"Qawasmeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Eid","family":"Al Mohtasib","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yousef Abu","family":"Asbeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-36-20260304","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.autrev.2015.09.005","article-title":"Thymoma associated with autoimmune diseases: 85 cases and literature review","volume":"15","author":"Bernard","year":"2016","journal-title":"Autoimmun. Rev"},{"key":"R2-36-20260304","first-page":"73","article-title":"Malignant thymoma associated with autoinimune diseases:a retrospective study and review of the literature","volume":"28","author":"Levy","year":"1998","journal-title":"seminArthritis Rheum"},{"key":"R3-36-20260304","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.ijsu.2020.10.034","article-title":"Guideline: updating consensus surgical CAse REport (SCARE) guidelines","volume":"84","author":"Agha","year":"2020","journal-title":"Int. J. Surg"},{"key":"R4-36-20260304","doi-asserted-by":"crossref","first-page":"980","DOI":"10.12998\/wjcc.v3.i12.980","article-title":"Myasthenia gravis and thymic neoplasms: a brief review","volume":"3","author":"Kumar","year":"2015","journal-title":"World J. Clin. Cases"},{"key":"R5-36-20260304","doi-asserted-by":"crossref","first-page":"153","DOI":"10.15605\/jafes.034.02.05","article-title":"Concurrence of myasthenia gravis and thyroid disorders: a retrospective database study","volume":"34","author":"Virameteekul","year":"2019","journal-title":"J. ASEAN Fed. Endocr. Soc"},{"key":"R6-36-20260304","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1056\/NEJM199406233302507","article-title":"Myasthenia gravis","volume":"330","author":"Drachman","year":"1994","journal-title":"N. Engl. J. Med"},{"key":"R9-36-20260304","first-page":"495","article-title":"Video-assisted thoracoscopic surgery versus open thymectomy for thymoma: a systematic review","volume":"4","author":"Xie","year":"2015","journal-title":"Ann. Cardiothorac. Surg"},{"key":"R10-36-20260304","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1016\/j.athoracsur.2008.12.095","article-title":"Thymomas: review of current clinical practice","volume":"87","author":"Tomaszek","year":"2009","journal-title":"Ann. Thorac. Surg"},{"key":"R11-36-20260304","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.jtcvs.2010.09.003","article-title":"Comparison of surgical techniques for early-stage thymoma: feasibility of minimally invasive thymectomy and comparison with open resection","volume":"141","author":"Pennathur","year":"2011","journal-title":"J. Thorac. Cardiovasc. Surg"},{"key":"R12-36-20260304","first-page":"322","article-title":"Video-assisted thoracoscopic surgical thymectomy to treat early thymoma: a comparison with the conventional transsternal approach","volume":"211","author":"Liu","year":"2013","journal-title":"Ann. Surg. Oncol"},{"key":"R13-36-20260304","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3904\/kjim.1996.11.1.40","article-title":"Prognostic factors of patients with thymoma","volume":"11","author":"Lee","year":"1996","journal-title":"Korean J. Intern. Med"},{"key":"R14-36-20260304","doi-asserted-by":"crossref","first-page":"4177","DOI":"10.3892\/ol.2016.4528","article-title":"Myasthenia gravis in patients with thymoma affects survival rate following extended thymectomy","volume":"11","author":"Zhang","year":"2016","journal-title":"Oncol. 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