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It is over two year that the COVID-19 pandemic has impacted the world and costed millions of lives.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation:<\/jats:title>\n                    <jats:p>The patient was a case of COVID-19 infection presenting as acute arterial occlusion in the upper and lower limb.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical discussion:<\/jats:title>\n                    <jats:p>Hyper coagulopathy is one of the COVID-19 outcomes that may develop PAD following the involvement of vascular endothelium in the cytokine storm phase. Endothelial damage following COVID-19, especially in those with underlying diseases such as diabetes mellitus or inflammatory diseases with vascular involvement, can cause acute vascular events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Patients with inflammatory diseases and diabetes are prone to the uncommon symptoms of COVID-19 and more vulnerable to peripheral vascular occlusion, especially when the underlying disease remains uncontrolled, so anticoagulation with therapeutic doses is recommended for their treatment. Inflammation as a predisposing factor for PAD should be controlled using plasmapheresis or anti-inflammatory drugs depending on the patient's condition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2022.107332","type":"journal-article","created":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T12:07:41Z","timestamp":1655813261000},"page":"107332","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Sudden development of the upper and lower limb ischemia as the first manifestation of COVID-19 infection"],"prefix":"10.1097","volume":"96","author":[{"given":"Shafagh","family":"Aliasgarzadeh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AmirAhmad","family":"Arabzadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sepideh","family":"Fathibitaraf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Negaresh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-56-20260309","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/S0140-6736(18)32279-7","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the global burden of disease study 2017","volume":"392","author":"James","year":"2018","journal-title":"Lancet"},{"key":"R2-56-20260309","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1024\/0301-1526\/a000527","article-title":"Treatment of acute lower limb ischaemia","volume":"45","author":"Lukasiewicz","year":"2016","journal-title":"Vasa"},{"key":"R3-56-20260309","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1253\/jcj.64.411","article-title":"Prediction of embolism in atrial fibrillation","volume":"64","author":"Abe","year":"2000","journal-title":"Jpn. 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