{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T03:25:11Z","timestamp":1774927511199,"version":"3.50.1"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T00:00:00Z","timestamp":1660867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Neurofibromatosis type 1 or Von Recklinghausen disease is a rare autosomal dominant hereditary disease with total penetrance. It is characterized by an extreme clinical variability that is also found within the same family.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Presentation of case:<\/jats:title>\n                    <jats:p>We report a case of neurofibroma exceptional by its location in the breast in a 40-year-old woman with Von Recklinghausen disease, discovered by a breast nodule on self-examination. A biopsy-exeresis had concluded on the anatomopathological examination to the diagnosis of neurofibroma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>Breast involvement in neurofibromatosis is extremely rare and possible. Rapid and adequate management of patients with Von Recklinghausen disease is essential in order to make the diagnosis early and to institute appropriate treatment as soon as possible, given the risk of possible malignant transformation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Diagnosis is essentially based on anatomopathological study. This confirms the diagnosis and rules out possible associated malignancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2022.107533","type":"journal-article","created":{"date-parts":[[2022,8,27]],"date-time":"2022-08-27T11:19:18Z","timestamp":1661599158000},"page":"107533","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Breast neurofibroma"],"prefix":"10.1097","volume":"98","author":[{"given":"F.","family":"Watik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Harrad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Sami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sakher","family":"Mahdaoui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Houssine","family":"Boufettal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naima","family":"Samouh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R2-58-20260309","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1477-7819-5-23","article-title":"Solitary neurofibroma in the male breast","volume":"27","author":"Jeyaretna","year":"2007","journal-title":"World J. Surg. Oncol"},{"key":"R3-58-20260309","first-page":"822","article-title":"Tumeur palp\u00e9brale isol\u00e9e r\u00e9v\u00e9latrice de la neurofibromatose de Von Recklinghausen: \u00e0 propos d'un cas","volume":"25","author":"Fany","year":"2002","journal-title":"J. Fr. Ophtalmol"},{"key":"R4-58-20260309","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1007\/s12282-009-0119-7","article-title":"Breast cancer associated with type 1 neurofibromatosis","volume":"17","author":"Salemis","year":"2010","journal-title":"Breast Cancer"},{"key":"R5-58-20260309","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/BF02967173","article-title":"T1 breast cancer associated with Von Recklinghausen's neurofibromatosis","volume":"6","author":"Murayama","year":"1999","journal-title":"Breast Cancer"},{"key":"R6-58-20260309","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/j.1524-4741.2007.00552.x","article-title":"Problems with the use of breast conservation therapy for breast cancer in a patient with neurofibromatosis type 1: a case report","volume":"14","author":"Hasson","year":"2008","journal-title":"Breast J"},{"key":"R8-58-20260309","first-page":"71","article-title":"Neurofibrome g\u00e9ant du sein r\u00e9v\u00e9lateur d'une maladie de Von Recklinghausen: \u00c0 propos d'un cas","volume":"347","author":"Lamalmi","year":"2002","journal-title":"Rev. Fr. Lab"},{"key":"R9-58-20260309","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/sj.bjc.6603227","article-title":"A prospective study of neurofibromatosis type 1 cancer incidence in the UK.Genetics and Genomics","volume":"95","author":"Walker","year":"2006","journal-title":"Br. J. Cancer"},{"key":"R10-58-20260309","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1524-4741.2004.09616.x","article-title":"An unusual presentation of neurofibromatosis of the breast: case report","volume":"10","author":"Millman","year":"2004","journal-title":"Breast J"},{"key":"R11-58-20260309","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1259\/bjr\/33539044","article-title":"Myxoid neurofibromas of the breast: mammographical, sonographical and MRI appearances","volume":"80","author":"Gokalp","year":"2007","journal-title":"Br. J. 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Surg"}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261222007799?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261222007799?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2022.107533","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T09:10:46Z","timestamp":1773047446000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2022.107533"}},"subtitle":["A case report"],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":10,"journal-issue":{"issue":"C","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2022.107533","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]}}}