{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T08:26:30Z","timestamp":1776759990898,"version":"3.51.2"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,25]],"date-time":"2022-09-25T00:00:00Z","timestamp":1664064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec>\n                    <jats:title>ABSTRACT<\/jats:title>\n                    <jats:p>Cystitis Glandularis (CG) is an unusual proliferative disease of the bladder. This condition was associated with chronic inflammation or chronic obstruction. This condition usually presents as microscopic finding and the presence of large macroscopic lesion is a rare feature. Until now, the course of disease from transitional to cystitis glandularis is still unclear and the uncertainty of CG to potentially develop into adenocarcinoma has once been documented. Herewith, we report our experience with 2 years old boy with cystitis glandularis presenting with LUTS obstructive symptoms, hematuria and bladder mass. Ultrasound examination revealed bilateral hydronephrosis with hydroureter and bladder wall thickness suggesting the sign of obstruction and chronic inflammation. Cystoscopy examination was performed to ensure the diagnosis with the result revealing protruding mass partially obstructing the bladder trigone, both ureteral orifice and posterior urethra. Transurethral resection was performed and the administration of COX-2 inhibitor and oral steroid therapy were given. Post-operative course was uneventful with the improvement in symptom and uroflowmetry revealed promising result. This case represented an entity of rare and interesting case of cystitis glandularis causing severe obstructive symptoms and urinary bladder mass which appropriate therapy of endoscopic intervention, COX-2 inhibitor and oral steroid resulted in promising outcome. Follow up of 1 year resulted in reduced LUTS symptoms such as straining and difficulty of urination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2022.107709","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T01:40:30Z","timestamp":1664329230000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Severe obstructive symptoms and urinary bladder mass due to cystitis glandularis"],"prefix":"10.1097","volume":"100","author":[{"given":"Ahmad","family":"Kusumaputra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilham Akbar","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soetojo","family":"Wirjopranoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-9-20260313","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s11255-006-9042-4","article-title":"Large cystitis glandularis: a very rare cause of severe obstructive urinary symptoms in an adult","volume":"39","author":"Kaya","year":"2007","journal-title":"Int. Urol. Nephrol"},{"key":"R2-9-20260313","first-page":"1689","article-title":"Campbell-Walsh urology, eleventh edition","volume":"53","author":"Wein","year":"2016","journal-title":"J. Chem. Inf. Model"},{"key":"R3-9-20260313","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.3892\/ol.2014.2360","article-title":"Cystitis glandularis: a controversial premalignant lesion","volume":"8","author":"Yi","year":"2014","journal-title":"Oncol. Lett"},{"key":"R4-9-20260313","doi-asserted-by":"crossref","first-page":"E306","DOI":"10.5489\/cuaj.2636","article-title":"The role of steroid treatment in intractable cystitis glandularis: a case report and literature review","volume":"9","author":"Yuksel","year":"2015","journal-title":"Can. Urol. Assoc. 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Urol"},{"key":"R12-9-20260313","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1111\/iju.13121","article-title":"Novel strategy for cystitis glandularis: oral treatment with cyclooxygenase-2 inhibitor","volume":"23","author":"Takizawa","year":"2016","journal-title":"Int. J. Urol"},{"key":"R13-9-20260313","doi-asserted-by":"crossref","first-page":"E72","DOI":"10.5489\/cuaj.11033","article-title":"A rare case of recurrent urinary obstruction and acute renal failure from cystitis cystica et glandularis","volume":"6","author":"Zhu","year":"2012","journal-title":"Can. Urol. Assoc. 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