{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T15:02:44Z","timestamp":1773414164331,"version":"3.50.1"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T00:00:00Z","timestamp":1665100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Pancreatic adenosquamous cell carcinoma (PASC) is a rare histological type of pancreatic malignancy with a particularly poor prognosis, even after curative surgery. Here, we describe the long-term prognosis of PASC in a patient who developed delayed local recurrence of the remnant pancreas after successful distal pancreatectomy, together with a literature review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Presentation of case:<\/jats:title>\n                    <jats:p>A 59-year-old woman had a history of hepatitis C. Computed tomography revealed a hypointense mass in the pancreatic body in the arterial phase of the study. Magnetic resonance imaging revealed a tumor (20 mm) in the pancreatic body and dilatation of the main pancreatic duct at the periphery of the tumor. The patient was diagnosed with resectable pancreatic ductal adenocarcinoma and underwent distal pancreatectomy with lymphadenectomy; her postoperative course was uneventful. Immunohistochemical analysis of the resected specimen confirmed the diagnosis of tumor node metastasis [TNM] classification T2N1M0 stage IIB. Five years after curative surgery, following adjuvant systemic chemotherapy with S-1, local recurrence in the remnant pancreas occurred, which invaded the common hepatic artery and celiac pleural plexus. Systemic chemotherapy with gemcitabine and abraxiane is currently underway.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>Curative surgery significantly affects the prognosis of patients with PASC. Adjuvant chemotherapy may prolong the survival of these patients. Delayed remnant pancreatic recurrence should be considered during the surveillance of pancreatic cancer after curative resection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>We present a case of PASC in a patient who developed local recurrence in the remnant pancreas 5 years after successful distal pancreatectomy. Special attention should be paid not only to early recurrence but also to delayed local recurrence in PASC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2022.107735","type":"journal-article","created":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T04:41:50Z","timestamp":1665463310000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Delayed local recurrence of pancreatic adenosquamous cell carcinoma after curative surgery"],"prefix":"10.1097","volume":"100","author":[{"given":"Atsuhiro","family":"Watanabe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Abe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiko","family":"Oshita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiji","family":"Hanada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshio","family":"Noriyuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Nakahara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-22-20260313","first-page":"7","article-title":"Cancer statistics, 2020","volume":"70","author":"Siegel","year":"2020","journal-title":"CA Cancer J. Clin"},{"key":"R2-22-20260313","first-page":"75","article-title":"Characteristics and outcomes of adenosquamous carcinoma of the pancreas","volume":"6","author":"Simone","year":"2013","journal-title":"Gastrointest. Cancer Res"},{"key":"R3-22-20260313","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jss.2011.06.015","article-title":"415 patients with adenosquamous carcinoma of the pancreas: a population-based analysis of prognosis and survival","volume":"174","author":"Boyd","year":"2012","journal-title":"J. Surg. Res"},{"key":"R4-22-20260313","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s11605-010-1378-5","article-title":"Adenosquamous versus adenocarcinoma of the pancreas: a population-based outcomes analysis","volume":"15","author":"Katz","year":"2011","journal-title":"J. Gastrointest. Surg"},{"key":"R5-22-20260313","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.humpath.2009.07.012","article-title":"Resected pancreatic adenosquamous carcinoma: clinicopathologic review and evaluation of adjuvant chemotherapy and radiation in 38 patients","volume":"41","author":"Voong","year":"2010","journal-title":"Hum. Pathol"},{"key":"R6-22-20260313","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1093\/jjco\/hyv088","article-title":"Cancer incidence and incidence rates in Japan in 2009: a study of 32 population-based cancer registries for the Monitoring of Cancer Incidence in Japan (MCIJ) project","volume":"45","author":"Hori","year":"2015","journal-title":"Jpn. J. Clin. Oncol"},{"key":"R7-22-20260313","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1093\/jjco\/hyq167","article-title":"Population-based survival of cancer patients diagnosed between 1993 and 1999 in Japan: a chronological and international comparative study","volume":"41","author":"Matsuda","year":"2011","journal-title":"Jpn. J. Clin. Oncol"},{"key":"R8-22-20260313","first-page":"115","article-title":"Efficacy of platinum chemotherapy agents in the adjuvant setting for adenosquamous carcinoma of the pancreas","volume":"6","author":"Wild","year":"2015","journal-title":"J. Gastrointest. Oncol"},{"key":"R9-22-20260313","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.ijsu.2018.10.031","article-title":"The PROCESS 2018 statement: updating consensus Preferred Reporting Of CasE Series in Surgery (PROCESS) guidelines","volume":"60","author":"Agha","year":"2018","journal-title":"Int. J. Surg"},{"key":"R10-22-20260313","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1097\/MPA.0000000000001548","article-title":"Adenosquamous carcinoma of the pancreas comprise a heterogeneous group of tumors with the worst outcome: a clinicopathological analysis of 25 cases identified in 562 pancreatic carcinomas resected with curative intent","volume":"49","author":"Boecker","year":"2020","journal-title":"Pancreas"},{"key":"R11-22-20260313","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1097\/MPA.0000000000000089","article-title":"Clinical characteristics of adenosquamous carcinoma of the pancreas: a matched case-control study","volume":"43","author":"Imaoka","year":"2014","journal-title":"Pancreas"},{"key":"R12-22-20260313","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/j.surg.2020.11.026","article-title":"The importance of multimodal therapy in the management of nonmetastatic adenosquamous carcinoma of the pancreas: analysis of treatment sequence and strategy","volume":"169","author":"Hue","year":"2021","journal-title":"Surgery"},{"key":"R13-22-20260313","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/jso.25112","article-title":"Comparative outcomes of adenosquamous carcinoma of the pancreas: an analysis of the National Cancer Database","volume":"118","author":"Hester","year":"2018","journal-title":"J. Surg. Oncol"},{"key":"R14-22-20260313","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1007\/s00432-019-03019-6","article-title":"Intra-arterial infusion chemotherapy versus isolated upper abdominal perfusion for advanced pancreatic cancer: a retrospective cohort study on 454 patients","volume":"145","author":"Aigner","year":"2019","journal-title":"J. Cancer Res. Clin. Oncol"},{"key":"R15-22-20260313","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1097\/DCR.0b013e3182420953","article-title":"Population-based evaluation of adenosquamous carcinoma of the colon and rectum","volume":"55","author":"Masoomi","year":"2012","journal-title":"Dis. Colon Rectum"},{"key":"R16-22-20260313","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1136\/jclinpath-2012-201084","article-title":"Low-grade adenosquamous carcinoma of the breast","volume":"66","author":"Soo","year":"2013","journal-title":"J. Clin. Pathol"},{"key":"R18-22-20260313","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.lungcan.2009.01.018","article-title":"Doubling time of lung cancer determined using three-dimensional volumetric software: comparison of squamous cell carcinoma and adenocarcinoma","volume":"66","author":"Honda","year":"2009","journal-title":"Lung Cancer"},{"key":"R19-22-20260313","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1164\/rccm.201107-1223OC","article-title":"Doubling times and CT screen-detected lung cancers in the Pittsburgh Lung Screening Study","volume":"185","author":"Wilson","year":"2012","journal-title":"Am. J. Respir. Crit. Care Med"},{"key":"R20-22-20260313","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/path.4943","article-title":"Genomic signatures of pancreatic adenosquamous carcinoma (PASC)","volume":"243","author":"Fang","year":"2017","journal-title":"J. Pathol"},{"key":"R21-22-20260313","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.jss.2020.09.024","article-title":"Clinical and histological basis of adenosquamous carcinoma of the pancreas: a 30-year experience","volume":"259","author":"Moslim","year":"2021","journal-title":"J. Surg. Res"},{"key":"R22-22-20260313","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.pan.2017.08.001","article-title":"Clinical implications of the proliferative ability of the squamous component regarding tumor progression of adenosquamous carcinoma of the pancreas: a preliminary report","volume":"17","author":"Hoshimoto","year":"2017","journal-title":"Pancreatology"},{"key":"R23-22-20260313","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s00595-014-0934-0","article-title":"Clinicopathological features and surgical outcomes of adenosquamous carcinoma of the pancreas: a retrospective analysis of patients with resectable stage tumors","volume":"45","author":"Komatsu","year":"2015","journal-title":"Surg. Today"},{"key":"R24-22-20260313","first-page":"99","article-title":"Survival following curative resection for pancreatic ductal adenocarcinoma. A systematic review of the literature","volume":"9","author":"Garcea","year":"2008","journal-title":"JOP"},{"key":"R25-22-20260313","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1007\/s00423-004-0476-9","article-title":"Survival after surgical management of pancreatic adenocarcinoma: does curative and radical surgery truly exist?","volume":"390","author":"Smeenk","year":"2005","journal-title":"Langenbeck's Arch. Surg"},{"key":"R26-22-20260313","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1097\/01.sla.0000245845.06772.7d","article-title":"Surgery for recurrent pancreatic ductal adenocarcinoma","volume":"245","author":"Kleeff","year":"2007","journal-title":"Ann. Surg"},{"key":"R27-22-20260313","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.surg.2018.05.050","article-title":"Resection for recurrent pancreatic cancer in the remnant pancreas after pancreatectomy is clinically promising: results of a project study for pancreatic surgery by the Japanese Society of Hepato-Biliary-Pancreatic Surgery","volume":"164","author":"Yamada","year":"2018","journal-title":"Surgery"},{"key":"R29-22-20260313","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1007\/s00595-013-0708-0","article-title":"Pancreatic cancer in the remnant pancreas following primary pancreatic resection","volume":"44","author":"Hashimoto","year":"2014","journal-title":"Surg. Today"}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261222009816?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261222009816?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2022.107735","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T11:03:03Z","timestamp":1773399783000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2022.107735"}},"subtitle":["A case report"],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":27,"journal-issue":{"issue":"C","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2022.107735","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]}}}