{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T20:19:04Z","timestamp":1789071544459,"version":"build-2803163510"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T00:00:00Z","timestamp":1672272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction and importance:<\/jats:title>\n                    <jats:p>Carcinoid tumors are rare malignancies of neuroendocrine origin that can manifest with a constellation of systemic symptoms including right-sided cardiac involvement. Many patients with carcinoid heart disease require valve replacement, but intraoperative management of carcinoid syndrome varies within the literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation:<\/jats:title>\n                    <jats:p>A 72-year-old man with carcinoid syndrome underwent tricuspid and pulmonic valve replacement with multiple episodes of carcinoid crisis intraoperatively as well as right ventricular dysfunction after cardiopulmonary bypass.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical discussion:<\/jats:title>\n                    <jats:p>Octreotide is the mainstay in prevention and treatment of intraoperative carcinoid crisis, but reported dosages and timing varies significantly. The use of exogenous catecholamines is also controversial as they are thought to paradoxically worsen carcinoid symptoms. Our patient was managed successfully with both an octreotide infusion and intermittent boluses, as well as exogenous catecholamines for right ventricular support during and after cardiopulmonary bypass.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The management of carcinoid syndrome in patients undergoing valve surgery for carcinoid heart disease is dependent on timely prevention and treatment of carcinoid crisis and effective mitigation of right ventricular dysfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2022.107855","type":"journal-article","created":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T01:51:34Z","timestamp":1672624294000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Balancing carcinoid crisis and right ventricular dysfunction during tricuspid and pulmonic valve replacement for carcinoid heart disease"],"prefix":"10.1097","volume":"102","author":[{"given":"Adam R.","family":"Pagryzinski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Schena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jutta","family":"Novalija","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Hossein","family":"Almassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul S.","family":"Pagel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dustin","family":"Hang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-48-20260313","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.jclinane.2010.12.009","article-title":"Carcinoid syndrome and perioperative anesthetic considerations","volume":"23","author":"Mancuso","year":"2011","journal-title":"J. Clin. Anesth"},{"key":"R2-48-20260313","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1053\/j.jvca.2017.11.027","article-title":"Anesthetic management of patients with carcinoid syndrome and carcinoid heart disease: the Mount Sinai Algorithm","volume":"32","author":"Castillo","year":"2018","journal-title":"J. Cardiothorac. Vasc. Anesth"},{"key":"R3-48-20260313","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1136\/hrt.2004.040329","article-title":"Carcinoid heart disease: presentation, diagnosis, and management","volume":"90","author":"Fox","year":"2004","journal-title":"Heart"},{"key":"R4-48-20260313","doi-asserted-by":"crossref","first-page":"662","DOI":"10.3390\/cancers14030662","article-title":"Carcinoid crisis: a misunderstood and unrecognized oncological emergency","volume":"14","author":"Bardasi","year":"2022","journal-title":"Cancers"},{"key":"R5-48-20260313","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1053\/j.jvca.2021.10.030","article-title":"Dealing with the right side: carcinoid heart disease","volume":"36","author":"Alvarez-Villegas","year":"2022","journal-title":"J. Cardiothorac. Vasc. Anesth"},{"key":"R6-48-20260313","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.ijsu.2020.10.034","article-title":"The SCARE 2020 guideline: updating consensus Surgical Case Report (SCARE) guidelines","volume":"84","author":"Agha","year":"2020","journal-title":"Int. J. Surg"},{"key":"R7-48-20260313","first-page":"9","article-title":"Carcinoid: the disease and its implications for anaesthesia","volume":"11","author":"Powell","year":"2011","journal-title":"Contin.Educ.Anaesth.Crit.CarePain"},{"key":"R8-48-20260313","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/0735-1097(94)00374-Y","article-title":"Outcome of cardiac surgery for carcinoid heart disease","volume":"25","author":"Connolly","year":"1995","journal-title":"J. Am. Coll. Cardiol"},{"key":"R9-48-20260313","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3390\/curroncol13020006","article-title":"Guidelines for the diagnosis and management of carcinoid tumours. Part 1: the gastrointestinal tract. A statement from a Canadian National Carcinoid Expert Group","volume":"13","author":"Maroun","year":"2006","journal-title":"Curr. Oncol"},{"key":"R10-48-20260313","first-page":"356","article-title":"Results of contemporary valve surgery in patients with carcinoid heart disease","volume":"25","author":"Kuntze","year":"2016","journal-title":"J. Heart Valve Dis"},{"key":"R11-48-20260313","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1002\/jso.23323","article-title":"Octreotide LAR and bolus octreotide are insufficient for preventing intraoperative complications in carcinoid patients","volume":"107","author":"Massimino","year":"2013","journal-title":"J. Surg. Oncol"},{"key":"R12-48-20260313","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1161\/01.CIR.92.4.790","article-title":"Carcinoid heart disease. Correlation of high serotonin levels with valvular abnormalities detected by cardiac catheterization and echocardiography","volume":"92","author":"Robiolio","year":"1995","journal-title":"Circulation"},{"key":"R13-48-20260313","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/nrendo.2009.51","article-title":"Fibrosis and carcinoid syndrome: from causation to future therapy","volume":"5","author":"Druce","year":"2009","journal-title":"Nat. Rev. Endocrinol"},{"key":"R14-48-20260313","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1159\/000381930","article-title":"Carcinoid heart disease: from pathophysiology to treatment - 'something in the way it moves'","volume":"101","author":"Grozinsky-Glasberg","year":"2015","journal-title":"Neuroendocrinology"},{"key":"R15-48-20260313","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jtcvs.2018.09.025","article-title":"Improving outcome of valve replacement for carcinoid heart disease","volume":"158","author":"Nguyen","year":"2019","journal-title":"J. Thorac. Cardiovasc. Surg"},{"key":"R16-48-20260313","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.ejcts.2010.10.035","article-title":"Outcomes, risks and complications of cardiac surgery for carcinoid heart disease","volume":"40","author":"Bhattacharyya","year":"2011","journal-title":"Eur. J. Cardiothorac. Surg"},{"key":"R17-48-20260313","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1159\/000461583","article-title":"ENETS consensus guidelines for the standards of care in neuroendocrine tumors: pre- and perioperative therapy in patients with neuroendocrine tumors","volume":"105","author":"Kaltsas","year":"2017","journal-title":"Neuroendocrinology"},{"key":"R18-48-20260313","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.surg.2015.05.036","article-title":"Continuous infusion of octreotide combined with perioperative octreotide bolus does not prevent intraoperative carcinoid crisis","volume":"159","author":"Condron","year":"2016","journal-title":"Surgery"},{"key":"R19-48-20260313","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.surg.2021.03.063","article-title":"A prospective study of carcinoid crisis with no perioperative octreotide","volume":"171","author":"Wonn","year":"2022","journal-title":"Surgery"},{"key":"R20-48-20260313","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.amjsurg.2018.12.070","article-title":"B-adrenergic agonist administration is not associated with secondary carcinoid crisis in patients with carcinoid tumor","volume":"217","author":"Limbach","year":"2019","journal-title":"Am. J. Surg"}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261222011014?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261222011014?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2022.107855","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T11:02:06Z","timestamp":1773399726000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2022.107855"}},"subtitle":["A case report"],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":20,"journal-issue":{"issue":"C","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2022.107855","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]}}}