{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T15:53:33Z","timestamp":1773849213536,"version":"3.50.1"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,19]],"date-time":"2023-03-19T00:00:00Z","timestamp":1679184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction and importance:<\/jats:title>\n                    <jats:p>Carney complex (CNC) is an extremely infrequent multiple endocrine neoplasia syndrome characterized by distinctive pigmented skin and mucosal lesions, cardiac and noncardiac myxomatous tumors, and multiple endocrine tumors. We herein report a case of CNC and surgical and history of laparoscopic left adrenalectomy complicated with a primary pigmented nodular adrenocortical disease (PPNAD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Presentation of case:<\/jats:title>\n                    <jats:p>We present the case of a 38-year-old woman with a previous diagnosis of CNC and history of laparoscopic left adrenalectomy who consulted for severe depression refractory to medical treatment. In the laboratory tests performed, altered ACTH, prolactin, Somatomedin C-IGF-1 and estradiol. An abdomen and pelvis C\/T scan was requested, where an 8 mm lesion was found at the level of the right adrenal gland. Laparoscopic right adrenalectomy was performed. Histopathology of the surgical resection specimen revealed PPNAD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>CNC is an infrequent syndrome with autosomal dominant inheritance and genetically heterogeneous. PPNAD is a consistent feature in CNC patients, however, reports of Cushing's syndrome in the literature indicate that only 25-45 % of CNC patients have PPNAD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>PPNAD can be present in patients with Carney complex, with surgical adrenalectomy history. With an adequate selection of patients, laparoscopic adrenalectomy with subsequent hormone replacement therapy should be performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2023.108016","type":"journal-article","created":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T07:05:11Z","timestamp":1679382311000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Laparoscopic right adrenalectomy in a patient with Carney syndrome"],"prefix":"10.1097","volume":"105","author":[{"given":"Ramiro A.","family":"Vargas Aignasse","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana A.","family":"Pantoja Pachajoa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"German R.","family":"Viscido","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro M.","family":"Doniquian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Facundo I.","family":"Mandojana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-50-20260318","doi-asserted-by":"crossref","first-page":"4041","DOI":"10.1210\/jcem.86.9.7903","article-title":"Clinical and molecular features of the Carney complex: diagnostic criteria and recommendations for patient evaluation","volume":"86","author":"Stratakis","year":"2001","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"R2-50-20260318","doi-asserted-by":"crossref","first-page":"M85","DOI":"10.1530\/EJE-15-0209","article-title":"Carney complex: an update","volume":"173","author":"Correa","year":"2015","journal-title":"Eur. J. Endocrinol"},{"key":"R3-50-20260318","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.endonu.2011.03.001","article-title":"Complejo de Carney [Carney complex], Spanish","volume":"58","author":"Losada Grande","year":"2011","journal-title":"Endocrinol Nutr"},{"key":"R4-50-20260318","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/79238","article-title":"Mutaciones del gen que codifica la subunidad reguladora tipo I-alfa de la prote\u00edna quinasa A en pacientes con el complejo de Carney","volume":"26","author":"Kirschner","year":"2000","journal-title":"Nat Genet"},{"key":"R5-50-20260318","first-page":"2085","article-title":"Mutaciones en la subunidad reguladora tipo 1A de la prote\u00edna quinasa dependiente de 5'-monofosfato de adenosina c\u00edclica (PRKAR1A): an\u00e1lisis de fenotipo en 353 pacientes y 80 genotipos diferentes","volume":"94","author":"Bertherat","year":"2009","journal-title":"Rev. Endocrinol. Cl\u00edn. Metabolismo"},{"key":"R6-50-20260318","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1038\/ng1809","article-title":"A genome-wide scan identifies mutations in the gene encoding phosphodiesterase 11A4 (PDE11A) in individuals with adrenocortical hyperplasia","volume":"38","author":"Horvath","year":"2006","journal-title":"Nat. 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Orphanet Enfermedades Raras"},{"key":"R13-50-20260318","doi-asserted-by":"crossref","first-page":"4041","DOI":"10.1210\/jcem.86.9.7903","article-title":"Caracter\u00edsticas cl\u00ednicas y moleculares del complejo de Carney: Criterios de diagn\u00f3stico y recomendaciones para la evaluaci\u00f3n del paciente","volume":"86","author":"Stratakis","year":"2001","journal-title":"Journal of Clinical Endocrinology & Metabolism"},{"key":"R14-50-20260318","doi-asserted-by":"crossref","first-page":"183","DOI":"10.17533\/udea.iatreia.123","article-title":"Complejo de Carney: reporte de un caso y revisi\u00f3n de la literatura","volume":"35","author":"Guti\u00e9rrez-Restrepo","year":"2022","journal-title":"Iatreia"},{"key":"R15-50-20260318","first-page":"132","article-title":"Adrenal pathophysiology: lessons from the carney complex","volume":"64","author":"Groussin","year":"2005","journal-title":"Horm. 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