{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T10:58:51Z","timestamp":1773658731264,"version":"3.50.1"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,8]],"date-time":"2023-10-08T00:00:00Z","timestamp":1696723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction and importance:<\/jats:title>\n                    <jats:p>Pediatric hepatic tumors present diagnostic challenges due to diverse clinical presentations and limited patient communication. Elevated serum alpha-fetoprotein (AFP) levels, often associated with hepatoblastoma, can occur in various hepatic conditions, adding complexity to diagnosis. This report emphasizes the importance of comprehensive assessment and integrated interpretation in such cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation:<\/jats:title>\n                    <jats:p>We present a rare case of a 1-year-old female child with abdominal swelling and hepatomegaly. Imaging revealed a hypodense hepatic lesion with punctate calcifications. Initial biopsy suggested mesenchymal hamartoma, but subsequent biopsy confirmed hepatoblastoma, highlighting the diagnostic complexity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical discussion:<\/jats:title>\n                    <jats:p>Hepatoblastoma is the most common pediatric liver tumor, typically presenting with nonspecific symptoms. Serum AFP levels are elevated, aiding diagnosis. Imaging reveals heterogeneous, hypervascular masses. Treatment includes surgery and chemotherapy. Mesenchymal hamartoma is a rare benign tumor with variable symptoms and imaging features, emphasizing the need for histopathological confirmation. This case underscores the importance of a comprehensive diagnostic approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Diagnosing pediatric hepatic tumors requires an integrated assessment of clinical, laboratory, and imaging findings. Confirmatory biopsies are essential, as demonstrated by this case, where an initial diagnosis of mesenchymal hamartoma was revised to hepatoblastoma. Collaborative, multidisciplinary approaches are crucial for accurate diagnosis and effective therapeutic planning, offering hope for improved outcomes in these complex cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2023.108931","type":"journal-article","created":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T13:52:50Z","timestamp":1696945970000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Mesenchymal hamartoma versus hepatoblastoma"],"prefix":"10.1097","volume":"112","author":[{"given":"Arkadeep","family":"Dhali","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harendra","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shivangi","family":"Sengupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jyotirmoy","family":"Biswas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bharat","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gopal Krishna","family":"Dhali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-24-20260316","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1002\/pbc.24215","article-title":"The epidemiology of hepatoblastoma","volume":"59","author":"Spector,","year":"2012","journal-title":"Pediatr. 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Pediatr"},{"key":"R5-24-20260316","doi-asserted-by":"crossref","first-page":"3301","DOI":"10.1200\/JCO.2010.29.3837","article-title":"Complete surgical resection is curative for children with hepatoblastoma with pure fetal histology: a report from the Children's Oncology Group","volume":"29","author":"Malogolowkin,","year":"2011","journal-title":"J. Clin. Oncol"},{"key":"R6-24-20260316","first-page":"122","article-title":"Risk-stratified staging in paediatric hepatoblastoma: a unified analysis from the Children's Hepatic Tumors International Collaboration [published correction appears in Lancet Oncol. 2017;18(4):e191]","volume":"18","author":"Meyers,","year":"2017","journal-title":"Lancet Oncol"},{"key":"R7-24-20260316","first-page":"28","article-title":"Magnetic resonance imaging of pediatric liver tumors: how we review and report","volume":"21","author":"Vasireddi,","year":"2021","journal-title":"Cancer Imaging"},{"key":"R8-24-20260316","first-page":"333","article-title":"Pediatric primary hepatic tumors: diagnostic considerations [published online ahead of print, 2021 Feb 18]","volume":"11","author":"Lucas,","year":"2021","journal-title":"Diagnostics (Basel"},{"key":"R10-24-20260316","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ejca.2015.09.023","article-title":"The Children's Hepatic tumors International Collaboration (CHIC): Novel global rare tumor database yields new prognostic factors in hepatoblastoma and becomes a research model [published correction appears in Eur J Cancer. 2016 Apr;57:144].","volume":"52","author":"Czauderna","year":"2016","journal-title":"Eur. J. Cancer"},{"key":"R12-24-20260316","doi-asserted-by":"crossref","first-page":"905089","DOI":"10.3389\/fped.2022.905089","article-title":"Case report of congenital hepatoblastoma with the onset at 30-weeks' gestation","volume":"10","author":"Yan,","year":"2022","journal-title":"Front. Pediatr"},{"key":"R13-24-20260316","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1186\/s12887-020-02059-z","article-title":"Outcomes of children with hepatoblastoma who underwent liver resection at a tertiary hospital in China: a retrospective analysis","volume":"20","author":"Li,","year":"2020","journal-title":"BMC Pediatr"},{"key":"R14-24-20260316","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s12029-019-00256-3","article-title":"Hepatoblastoma in a young adult: a rare case report and review of the literature","volume":"51","author":"Vishnoi,","year":"2020","journal-title":"J. Gastrointest. 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