{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T10:58:46Z","timestamp":1773658726868,"version":"3.50.1"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,8]],"date-time":"2023-10-08T00:00:00Z","timestamp":1696723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction and importance:<\/jats:title>\n                    <jats:p>Langerhans cell histiocytosis (LCH) is a proliferation of dendritic mononuclear cells with infiltration into organs locally or diffusely. Its aetiology is still unknown, and its clinical spectrum is quite wide.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation:<\/jats:title>\n                    <jats:p>A 2-year-old-male child presented to us with a solitary swelling in left mandibular region which was painless and increasing in size with time. It was diagnosed to be unifocal LCH of mandible on the basis of X-ray, ultrasonography of the involved mandible and fine needle aspiration cytology of the swelling and managed conservatively with oral steroids.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>LCH is often classified as single system, when the disease affects only one part of the body; or multisystem, when it affects more than one part of the body (Jezierska et al., 2018 [1]). In children, histiocytosis usually involves the bones and may consist of single or multiple sites. The skull is frequently affected. Children over five years of age usually have the single system disease, with just bone involvement but our patient was 2-year-old and had unifocal disease involving mandible. Young children, especially infants, are more likely to have the multisystem disease (Jezierska et al., 2018 [1]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Mandibular involvement associated with LCH is quite uncommon in paediatric population. Early diagnosis and prompt initiation of treatment are key to a good eventual outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2023.108940","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T04:31:56Z","timestamp":1696998716000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Mandibular unifocal Langerhans cell histiocytosis in a child - Report of successful management of a rare condition"],"prefix":"10.1097","volume":"112","author":[{"given":"Pradeep","family":"Kajal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Himanshi","family":"Dhingra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Namita","family":"Bhutani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-33-20260316","doi-asserted-by":"crossref","first-page":"6","DOI":"10.5114\/pdia.2017.67095","article-title":"Langerhans cell histiocytosis in children - a disease with many faces. Recent advances in pathogenesis, diagnostic examinations and treatment","volume":"35","author":"Jezierska,","year":"2018","journal-title":"Postepy Dermatol. Alergol"},{"key":"R2-33-20260316","doi-asserted-by":"crossref","first-page":"3","DOI":"10.5070\/D317B778J6","article-title":"Langerhans cell histiocytosis: a case report and summary of the current recommendations of the Histiocyte Society","volume":"14","author":"Satter,","year":"2008","journal-title":"Dermatol. Online J"},{"key":"R3-33-20260316","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.amsu.2019.07.030","article-title":"Diagnosis and treatment of Langerhans cell histiocytosis with bone lesion in pediatric patient: a case report","volume":"45","author":"Kamal,","year":"2019","journal-title":"Ann. Med. Surg. (Lond"},{"key":"R4-33-20260316","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1056\/NEJMra1607548","article-title":"Langerhans-cell histiocytosis","volume":"379","author":"Allen,","year":"2018","journal-title":"N. Engl. J. Med"},{"key":"R5-33-20260316","doi-asserted-by":"crossref","first-page":"276","DOI":"10.4103\/0972-124X.85675","article-title":"Langerhans cell histiocytosis","volume":"15","author":"Aruna,","year":"2011","journal-title":"J. Indian Soc. Periodontol"},{"key":"R6-33-20260316","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1182\/blood.2021014343","article-title":"International expert consensus recommendations for the diagnosis and treatment of Langerhans cell histiocytosis in adults","volume":"139","author":"Goyal,","year":"2022","journal-title":"Blood"},{"key":"R7-33-20260316","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.ijsu.2020.10.034","article-title":"The SCARE 2020 guideline: updating consensus Surgical Case Report (SCARE) guidelines","volume":"84","author":"Agha,","year":"2020","journal-title":"Int. J. Surg"},{"key":"R8-33-20260316","doi-asserted-by":"crossref","first-page":"167","DOI":"10.5125\/jkaoms.2019.45.3.167","article-title":"Langerhans cell histiocytosis of the mandible: two case reports and literature review","volume":"45","author":"Hwang,","year":"2019","journal-title":"J. Korean Assoc. Oral Maxillofac. Surg"},{"key":"R9-33-20260316","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.ijom.2004.10.020","article-title":"Intralesional infiltration of corticosteroids in the treatment of localised langerhans' cell histiocytosis of the mandible report of known cases and three new cases","volume":"34","author":"Putters,","year":"2005","journal-title":"Int. J. Oral Maxillofac. Surg"}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261223010696?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261223010696?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2023.108940","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T10:01:06Z","timestamp":1773655266000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2023.108940"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":9,"journal-issue":{"issue":"C","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2023.108940","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]}}}