{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T02:27:21Z","timestamp":1782354441777,"version":"3.54.5"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Van Wyk-Grumbach syndrome (VWGS) is a rare presentation of long-standing hypothyroidism, characterized by delayed bone age, enlarged bilateral multicystic ovaries, and isosexual precocious puberty.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation:<\/jats:title>\n                    <jats:p>We report here the clinical details of the case of Van Wyk Grumbach Syndrome in an 11-year-old girl who was first presented to the pediatric surgeon for hemoperitoneum. The patient underwent an emergency exploratory laparotomy, which showed enlarged ovaries with multiple cysts that were bleeding. She also had severe hypothyroidism, hyperprolactinemia, hyperestrogenism, pituitary adenoma, and delayed bone age. Significant improvement in symptoms was noted after thyroid hormone replacement therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Importance and conclusion:<\/jats:title>\n                    <jats:p>This case highlights that it is crucial to consider thyroid assessment in a patient with multicystic ovaries to avoid misdiagnosis, unnecessary investigations for malignancy and\/or surgical intervention, and possible complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2023.109097","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T12:26:03Z","timestamp":1701174363000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Van Wyk-Grumbach syndrome: The importance of thyroid function tests in a child presenting with multicystic ovaries"],"prefix":"10.1097","volume":"114","author":[{"given":"A.","family":"Elouali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Ouerradi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Benhaddou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Kamaoui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Rkain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Babakhouya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-13-20260325","doi-asserted-by":"crossref","first-page":"115","DOI":"10.4103\/bjem.bjem_16_23","article-title":"Wyk-Grumbach Syndrome: a case report and review of the literature","volume":"2","author":"Kamatham,","year":"2023","journal-title":"Bangladesh J. Endocrinol. Metab."},{"issue":"3","key":"R2-13-20260325","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/S0022-3476(60)80250-8","article-title":"Syndrome of precocious menstruation and galactorrhea in juvenile hypothyroidism: an example of hormonal overlap in pituitary feedback","volume":"57","author":"Van Wyk,","year":"1960","journal-title":"J. Pediatr."},{"key":"R3-13-20260325","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1016\/S0022-3468(03)00403-2","article-title":"Anindya Chattopadhyay, Vijaya Kumar, Mohan Marulaiah Karnataka. Polycystic ovaries, precocious puberty, and acquired hypothyroidism: the Van Wyk and Grumbach syndrome","volume":"38","journal-title":"J. Pediatr. Surg"},{"issue":"1","key":"R4-13-20260325","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.ijsu.2020.10.034","article-title":"The SCARE 2020 guideline: updating consensus Surgical Case Report (SCARE) guidelines","volume":"84","author":"Agha,","year":"2020","journal-title":"Int. J. Surg."},{"issue":"4","key":"R5-13-20260325","doi-asserted-by":"crossref","first-page":"170","DOI":"10.4274\/TP.2022.86548","article-title":"The importance of thyroid function tests in a patient presenting with precocious menarche: Van Wyk Grumbach syndrome","volume":"3","author":"K\u00f6pr\u00fcl\u00fc,","year":"2022","journal-title":"Trends Pediatr."},{"key":"R6-13-20260325","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.apme.2013.10.009","article-title":"Van Wyke Grumbach syndrome and pituitary hyperplasia in a six-year-old girl","volume":"11","author":"Hulse,","year":"2014","journal-title":"Apollo Med."},{"issue":"3","key":"R7-13-20260325","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1515\/jpem-2015-0157","article-title":"Diagnostic approach in children with unusual symptoms of acquired hypothyroidism. When to look for pituitary hyperplasia?","volume":"29","author":"Kocova,","year":"2016","journal-title":"J. Pediatr. Endocrinol. Metab."},{"key":"R8-13-20260325","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1186\/s13256-020-02472-z","article-title":"Van Wyk-Grumbach syndrome and oligo syndactyly in a 6-year-old girl: a case report","volume":"14","author":"Egodawaththe,","year":"2020","journal-title":"J. Med. Case Rep."},{"key":"R9-13-20260325","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.epsc.2019.01.010","article-title":"Van Wyk Grumbach syndrome with precocious puberty and ovarian cysts: value of thyroid function tests","volume":"43","author":"Panta,","year":"2019","journal-title":"J Pediatr Surg Case Rep"},{"key":"R10-13-20260325","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpag.2010.08.003","article-title":"Van Wyk and Grumbach syndrome: an unusual case and review of the literature","volume":"24","author":"Durbin,","year":"2011","journal-title":"J. Pediatr. Adolesc. Gynecol."},{"key":"R11-13-20260325","first-page":"1","article-title":"Van Wyk Grumbach syndrome and ovarian hyperstimulation in juvenile primary hypothyroidism: lessons from a 30-case cohort","volume":"7","author":"Boddu,","year":"2023","journal-title":"J. Endocr. Soc."}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261223012269?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261223012269?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2023.109097","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T10:19:25Z","timestamp":1774433965000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2023.109097"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":11,"journal-issue":{"issue":"C","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2023.109097","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"2023-10-04","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-27","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}