{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T18:13:40Z","timestamp":1787595220878,"version":"build-2736575974"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,5]],"date-time":"2023-12-05T00:00:00Z","timestamp":1701734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Treating advanced peripheral arterial occlusive disease (e.g. PAOD IV) poses a significant challenge, as conventional treatments quite often fall short at this stage. However, a range of interventions can be considered to postpone amputation. This study presents an example of advanced stage of Peripheral Artery Occlusive Disease (PAOD) stage IV, encompassing a history of a high thigh amputation on the left side, coupled with pronounced wound healing disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Presentation of case:<\/jats:title>\n                    <jats:p>Our patient, 55 years old, smoker and ASA Class III is in a left sided above-the knee-amputation situation. He presented to our outpatient clinic with blistering in the stump area, caused by non-proportinate pressure from the prosthesis. With an emerging septic course and advanced peripheral arterial occlusive disease (PAOD) at Fontaine class IV, revascularization was unfeasible in the left iliac artery axis and groin arteries. Additionally, a stage PAOD IV presents itself with poorly healing wounds on the right side which our patient still uses to support his transfers in and out bed and his wheelchair. Multiple surgical stump revisions and femur shortenings and diverse wound treatments were performed all were unsatisfying for patient and practitioners. We introduced a novel biochemisurgical treatment in our teaching hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>Desiccating-agent-A is an innovative dehydrating agent with potent desiccating characteristics upon application to organic substances. Its formulation involves blending 83% methane sulfonic acid with proton acceptors and dimethyl sulfoxide, as outlined in patent application. The case description results in an illustrated follow up period of 16 months and is presented in line with the recommendations of the consensus-based surgical case reporting guideline development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The goal of achieving a secondary healing trend is to establish stability within the wound area or achieve complete healing. This endeavor becomes particularly intricate when severe blood circulation compromise exists. Nonetheless, progress in wound treatment measures has made it feasible to achieve this aim by fostering the formation of dry and clean necrotic tissue. This dry and clean wound is now manageable in a patient's home situation, allowing for effective care and a better chance at preventing further severe complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2023.109103","type":"journal-article","created":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T11:57:47Z","timestamp":1702468667000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Innovative biochemisurgical treatment for stabilisation of an end-stage chronic wound in a complex vascular compromized patient"],"prefix":"10.1097","volume":"114","author":[{"given":"A.","family":"Algharib","sequence":"first","affiliation":[{"name":"Department of Vascular & Endovascular Surgery, EUREGIO Hospital, Albert-Schweitzer-Stra\u00dfe 10, 48527 Nordhorn, Niedersachsen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.M.C.","family":"van Dortmont","sequence":"additional","affiliation":[{"name":"Department of Vascular & Endovascular Surgery, EUREGIO Hospital, Albert-Schweitzer-Stra\u00dfe 10, 48527 Nordhorn, Niedersachsen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.G.R.","family":"Hendrix","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, EUREGIO Hospital, Albert-Schweitzer-Stra\u00dfe 10, 48527 Nordhorn, Niedersachsen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Riedel","sequence":"additional","affiliation":[{"name":"Department of Vascular & Endovascular Surgery, EUREGIO Hospital, Albert-Schweitzer-Stra\u00dfe 10, 48527 Nordhorn, Niedersachsen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"M\u00f6ller","sequence":"additional","affiliation":[{"name":"Department of Vascular & Endovascular Surgery, EUREGIO Hospital, Albert-Schweitzer-Stra\u00dfe 10, 48527 Nordhorn, Niedersachsen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.G.","family":"Koning","sequence":"additional","affiliation":[{"name":"Department of Vascular & Endovascular Surgery, EUREGIO Hospital, Albert-Schweitzer-Stra\u00dfe 10, 48527 Nordhorn, Niedersachsen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"6","key":"R1-19-20260325","doi-asserted-by":"crossref","DOI":"10.12968\/jowc.2022.31.6.480","article-title":"Cost-effectiveness of debrichem in managing hard-to-heal venous leg ulcers in the UK","volume":"31","author":"Guest,","year":"2022","journal-title":"J of Wound Care"},{"issue":"1","key":"R2-19-20260325","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/wrr.12683","article-title":"The humanistic and economic burden of chronic wounds: a systematic review","volume":"27","author":"Olsson,","year":"2019","journal-title":"Wound Repair Regen."},{"issue":"1","key":"R3-19-20260325","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/wrr.12496","article-title":"Relationship between opioid treatment and rate of healing in chronic wounds","volume":"25","author":"Shanmugam,","year":"2017","journal-title":"Wound Repair Regen."},{"issue":"10","key":"R4-19-20260325","doi-asserted-by":"crossref","DOI":"10.12968\/jowc.2022.31.10.816","article-title":"A desiccation compound as a biofilm- and necrosis-removing agent: a case series","volume":"31","author":"Cogo,","year":"2022","journal-title":"J. of Wound Care"},{"issue":"3","key":"R5-19-20260325","article-title":"A new option for chemical debridement using Debrichem to remove biofilm in hard-to-heal wounds. 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