{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:21:59Z","timestamp":1786990919197,"version":"build-2736575974"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,5]],"date-time":"2023-12-05T00:00:00Z","timestamp":1701734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070540"],"award-info":[{"award-number":["82070540"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010040","name":"Taishan Scholar Project of Shandong Province","doi-asserted-by":"publisher","award":["tsqn202211309"],"award-info":[{"award-number":["tsqn202211309"]}],"id":[{"id":"10.13039\/501100010040","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction and importance:<\/jats:title>\n                    <jats:p>Metastasis of primary lung cancer to the small intestine is rare, and the prognosis is poor. Early diagnosis of small intestinal metastasis is difficult because the incidence of clinically obvious symptoms is low.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation:<\/jats:title>\n                    <jats:p>This report described a rare case of small intestine metastasis of lung adenocarcinoma. It is worth noting that the patient was diagnosed with lung adenocarcinoma (T2aN0M0, stage IB) over a year ago. However, he complained of fever, black stools, and abdominal pain for about a year after the surgery. Enhanced CT scans showed thickening of the intestinal wall and dilatation of the lumen in the right iliac area and adjacent pelvic cavity. Capsule endoscopy identified a space-occupying lesion with hemorrhaging in the ileum. A laparotomy was subsequently performed, and the histopathological confirmation revealed a metastatic lung adenocarcinoma and immunohistochemistry further showed positive results for TTF-1 and CK7.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical discussion:<\/jats:title>\n                    <jats:p>When patients with a history of primary lung cancer experience gastrointestinal symptoms, the possibility of distant metastasis of lung cancer to the digestive tract should be considered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Due to the rarity of primary lung cancer metastasis to the small intestine, we report the case of a 64-year-old male who presented with symptoms of gastrointestinal bleeding and was ultimately diagnosed with metastasis of primary lung cancer to the small intestine. When patients with lung cancer present with gastrointestinal symptoms, we cannot rule out the possibility of distant metastasis from primary lung cancer, although this possibility is unlikely.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2023.109111","type":"journal-article","created":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T11:50:51Z","timestamp":1701863451000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Metastatic spread of primary lung adenocarcinoma to the small intestine: A case report"],"prefix":"10.1097","volume":"114","author":[{"given":"Jiayi","family":"Li","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Qilu Hospital, Shandong University, Jinan, Shandong, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Chinese People's Liberation Army No.960 Hospital, Jinan, Shandong Province, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanbo","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"25","key":"R1-27-20260325","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1056\/NEJMoa022136","article-title":"Staging of non-small-cell lung cancer with integrated positron-emission tomography and computed tomography","volume":"348","author":"Lardinois,","year":"2003","journal-title":"N. 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