{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T13:08:04Z","timestamp":1774444084229,"version":"3.50.1"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T00:00:00Z","timestamp":1701907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n Introduction:<\/jats:title>\n The management of patients with complex oncological histories poses unique challenges, particularly when they are on targeted chemotherapy agents known for specific side effects. This case report illuminates the multifaceted complexities encountered in such scenarios, with a focus on the rare complications associated with targeted therapies.<\/jats:p>\n <\/jats:sec>\n \n Case presentation:<\/jats:title>\n \n We present a 50-year-old male with an extensive oncological background, including childhood retinoblastoma and radiation-induced leiomyosarcoma. Recently diagnosed with skull base osteosarcoma, he was undergoing treatment with Regorafenib. Admitted with sepsis due to\n Pseudomonas aeruginosa<\/jats:italic>\n -induced community-acquired pneumonia, his clinical course was complicated by lung cavitation leading to a spontaneous pneumothorax. This report highlights the absence of empyema, a crucial differential in the diagnosis.\n <\/jats:p>\n <\/jats:sec>\n \n Discussion:<\/jats:title>\n This case unravels the intricate interplay between targeted chemotherapy, concurrent medications like prednisone, and their potential to cause severe complications such as pneumonia and pneumothorax. It delves into the mechanisms by which Regorafenib can lead to lung cavitation and abscess formation, a rare but significant risk. The importance of a multidisciplinary approach for prompt diagnosis and treatment, including surgical intervention, is highlighted. The pathology of the surgically resected lobe revealed metastatic high-grade leiomyosarcoma, adding another layer of complexity to the case.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n This case serves as a cautionary tale highlighting the need for vigilant monitoring of patients on targeted chemotherapy agents, especially those with complex medical histories. It highlights the importance of considering potential drug-related complications and the rationale behind therapeutic choices, including antibiotic selection and surgical decision-making, in the management of acute medical conditions in these patients.<\/jats:p>\n <\/jats:sec>\n \n Highlights<\/jats:title>\n <\/jats:sec>","DOI":"10.1016\/j.ijscr.2023.109157","type":"journal-article","created":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T02:21:47Z","timestamp":1702606907000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Lung cavitation to pneumothorax: A case report of the multilayered respiratory challenges in oncology patients"],"prefix":"10.1097","volume":"114","author":[{"given":"Nathaniel","family":"Grabill","sequence":"first","affiliation":[{"name":"Northeast Georgia Medical Center, General Surgery GME Program, United States of America"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mena","family":"Louis","sequence":"additional","affiliation":[{"name":"Northeast Georgia Medical Center, General Surgery GME Program, United States of America"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy","family":"Idowu","sequence":"additional","affiliation":[{"name":"Northeast Georgia Medical Center, General Surgery GME Program, United States of America"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clifton","family":"Hastings","sequence":"additional","affiliation":[{"name":"Northeast Georgia Medical Center, Cardiovascular and Thoracic Surgery, United States of America"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hardeep","family":"Singh","sequence":"additional","affiliation":[{"name":"Northeast Georgia Medical Center, Graduate Medical Education, Research Department, United States of America"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"issue":"1","key":"R1-70-20260325","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3892\/ol.2015.3905","article-title":"Early tumor cavitation with regorafenib in metastatic colorectal cancer: a case report","volume":"11","author":"Kawasaki,","year":"2016","journal-title":"Oncol. 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