{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T16:57:06Z","timestamp":1774544226606,"version":"3.50.1"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Locally advanced rectal cancer (LARC) is commonly managed with neoadjuvant chemoradiation (neoCRT) followed by surgery, though not without complications. The anatomical exposure of the colon and rectum and pelvic radiotherapy poses risk, with rectal perforation and bowel obstruction, though rare, carrying life-threatening potential.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Presentation of case:<\/jats:title>\n                    <jats:p>This case highlights an exceptionally rare occurrence of concurrent rectal perforation and rectal obstruction in a 77-year-old male with LARC, just two months post neoCRT. Initial symptoms included rectal bleeding, and diagnostic procedures confirmed rectal T1N3adenocarcinoma with no metastasis. Emergency admission, prompted by complete bowel obstruction symptoms, led to discovery of rectal perforation during laparotomy, sealed by the bladder. Pathological analysis attributed the cause to radiation proctitis, reporting complete response to neoCRT with no residual tumor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>The rarity of both bowel obstruction and perforation as neoCRT complications, particularly in the acute phase of radiation proctitis, is noteworthy in this case. The absence of tumoral cells at the affected sites emphasizes the exceptional nature of this case.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This case underscores the importance of recognizing acute post neoCRT injuries as potentially life-threatening complications, emphasizing the need for heightened awareness and consideration in clinical management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2024.109337","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T06:57:58Z","timestamp":1706857078000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Concurrent rectal perforation and obstruction following neoadjuvant chemoradiation for locally advanced rectal cancer: A case report"],"prefix":"10.1097","volume":"116","author":[{"given":"Tahmineh","family":"Tahouri","sequence":"first","affiliation":[{"name":"Pediatric Cardiology, Shahid Modarres Educational Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahand","family":"Hedayati Omami","sequence":"additional","affiliation":[{"name":"Farhikhtegan Hospital, School of Medicine, Azad University, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Hosseini","sequence":"additional","affiliation":[{"name":"Anatomical & Clinical Pathologist, Shahid Chamran Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ehsanollah","family":"Rahimi-Movaghar","sequence":"additional","affiliation":[{"name":"Department of Surgery, Farhikhtegan Hospital, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"issue":"1","key":"R1-26-20260326","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15010219","article-title":"Strategies to optimize treatment for locally advanced rectal Cancer","volume":"15","author":"Hu,","year":"2022","journal-title":"Cancers (Basel)."},{"issue":"2","key":"R2-26-20260326","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3748\/wjg.v19.i2.185","article-title":"Gastrointestinal radiation injury: symptoms, risk factors and mechanisms","volume":"19","author":"Shadad,","year":"2013","journal-title":"World J. Gastroenterol."},{"issue":"1","key":"R3-26-20260326","doi-asserted-by":"crossref","first-page":"18","DOI":"10.12998\/wjcc.v5.i1.18","article-title":"Local advanced rectal cancer perforation in the midst of preoperative chemoradiotherapy: a case report and literature review","volume":"5","author":"Takase,","year":"2017","journal-title":"World J. Clin. Cases"},{"issue":"6","key":"R4-26-20260326","doi-asserted-by":"crossref","first-page":"285","DOI":"10.14740\/gr1567","article-title":"Radiation in gastroenterology","volume":"15","author":"Ahmed,","year":"2022","journal-title":"Gastroenterology Res."},{"issue":"3","key":"R5-26-20260326","first-page":"362","article-title":"Radiation enteritis","volume":"35","author":"Vargas-Rubio,","year":"2020","journal-title":"Case report and literature review. Revista colombiana de Gastroenterolog\u00eda."},{"issue":"1","key":"R6-26-20260326","doi-asserted-by":"crossref","first-page":"22","DOI":"10.5946\/ce.2020.288","article-title":"Radiation Proctitis and management strategies","volume":"55","author":"Dahiya,","year":"2022","journal-title":"Clin Endosc."},{"issue":"3","key":"R7-26-20260326","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1055\/s-0041-1740041","article-title":"Pelvic radiation disease","volume":"35","author":"Sammour,","year":"2022","journal-title":"Clin. Colon Rectal Surg."},{"issue":"4","key":"R8-26-20260326","first-page":"315","article-title":"Radiation proctitis: a decade's experience","volume":"51","author":"Wong,","year":"2010","journal-title":"Singapore Med. 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