{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T14:24:24Z","timestamp":1783779864022,"version":"3.55.0"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T00:00:00Z","timestamp":1707091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82293660\/82293665"],"award-info":[{"award-number":["82293660\/82293665"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction and importance:<\/jats:title>\n                    <jats:p>Congenital hepatoblastoma is an exceedingly rare neoplasm, predominantly documented as isolated instances, with contentious aspects surrounding its therapeutic approaches and prognostic implications. This study aims to comprehensively summarize and evaluate the management experience of congenital hepatoblastoma (CHB).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation:<\/jats:title>\n                    <jats:p>This cohort comprised five infants diagnosed with hepatoblastoma, confirmed through pathological examination, and with an onset of symptoms before 28 days of age. They were enrolled between November 2019 and May 2022. The treatment course they underwent has been summarized, and their prognosis has been subject to analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical discussion:<\/jats:title>\n                    <jats:p>Distinguishing congenital hepatoblastoma from other medical conditions is typically necessary. Given the patient's tender age, the approach to treatment demands comprehensive assessment, particularly in cases involving unique tumor locations or substantial tumor sizes. The selection of treatment modalities, encompassing preoperative neoadjuvant chemotherapy and surgical techniques, becomes of paramount importance. Furthermore, determining the treatment's endpoint poses a notable challenge and often necessitates a comprehensive evaluation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>For pediatric patients afflicted with CHB, the application of preoperative neoadjuvant chemotherapy mitigates surgical risks, while the incorporation of surgical procedures followed by postoperative chemotherapy significantly enhances the overall prognosis. Additionally, AFP-L3% levels may serve as a valuable adjunctive marker signifying the conclusion of treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2024.109358","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T11:51:59Z","timestamp":1707306719000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["A case series of clinical characteristics and prognosis of congenital hepatoblastoma in a single center"],"prefix":"10.1097","volume":"116","author":[{"given":"Jiatong","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Pathology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanmin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"2","key":"R1-44-20260326","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1053\/j.semdp.2016.12.015","article-title":"Hepatoblastoma","volume":"34","author":"Sharma,","year":"2017","journal-title":"Semin. Diagn. Pathol."},{"issue":"6","key":"R2-44-20260326","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1002\/(SICI)1096-911X(199906)32:6<466::AID-MPO20>3.0.CO;2-1","article-title":"Congenital hepatoblastoma: a distinct entity?","volume":"32","author":"Ammann,","year":"1999","journal-title":"Med. Pediatr. Oncol."},{"issue":"11","key":"R3-44-20260326","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1002\/pbc.24655","article-title":"Outcomes for patients with congenital hepatoblastoma","volume":"60","author":"Trobaugh-Lotrario,","year":"2013","journal-title":"Pediatr. Blood Cancer"},{"issue":"1","key":"R4-44-20260326","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1203\/00006450-198101000-00012","article-title":"Serum alpha fetoprotein (AFP) levels in normal infants","volume":"15","author":"Wu,","year":"1981","journal-title":"Pediatr. 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