{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T23:33:41Z","timestamp":1783640021992,"version":"3.55.0"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T00:00:00Z","timestamp":1707350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction and importance:<\/jats:title>\n                    <jats:p>Total hip arthroplasty is one of the most performed surgical interventions in the world. Adverse local tissue reactions and pseudotumors are infrequent but dangerous eventualities, which are often related with metal-on-metal or metal-on-polyethylene implants. This study wants to highlight how adverse local tissue reactions and pseudotumors must be taken into consideration during the diagnostic process.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation:<\/jats:title>\n                    <jats:p>We report the case of a patient with ceramic-on-ceramic modular total hip arthroplasty with titanium neck. 12 years after surgery, he complained of pain and swelling on the hip. Diagnostic tests revealed the presence of a bulky pseudotumor. During the revision surgery biopsy samples were taken and microscopical analysis revealed the presence of fibrous tissue, fibrin hemorrhagic collections, histiocytes and chronic inflammation due to foreign body, with dark refractive material of an exogenous nature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical discussion:<\/jats:title>\n                    <jats:p>The possible formation of pseudotumor and metallosis reactions in hip prostheses with metal-on-metal coupling or in couplings with polyethylene is known. Many cases of pseudotumor are reported after revision of prostheses due to the breakage of ceramic components, but we did not observe any damage or corrosion of the prosthetic elements; on the other hand, we noticed an excessive retroversion of the femoral neck. It may be possible that an accurate microscopic analysis could clarify the failure of this implant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>To date ceramic-ceramic coupling remains the gold standard in terms of resistance and durability for hip arthroplasty but there is still a gap of knowledge in the field of tribology and individual immune response mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2024.109374","type":"journal-article","created":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T04:14:13Z","timestamp":1707797653000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Pseudotumor from ceramic-on-ceramic total hip arthroplasty"],"prefix":"10.1097","volume":"116","author":[{"given":"Corrado","family":"Ciatti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Maniscalco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Bosio","sequence":"additional","affiliation":[{"name":"Pathology Unit, Onco-Hematologic Department, Guglielmo Da Saliceto Hospital, AUSL Piacenza, Piacenza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Calogero","family":"Puma Pagliarello","sequence":"additional","affiliation":[{"name":"U.O.C. Orthopedics and Traumatology, Guglielmo Da Saliceto Hospital, AUSL Piacenza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Clinica Ortopedica III, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Quattrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-59-20260326","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s10195-023-00719-1","article-title":"Managing early complications in total hip arthroplasty: the safety of immediate revision","volume":"24","author":"Descamps,","year":"2023","journal-title":"J. Orthop. Traumatol."},{"key":"R2-59-20260326","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s10195-023-00711-9","article-title":"Comparison of mortality rate and septic and aseptic revisions in total hip arthroplasties for osteoarthritis and femoral neck fracture: an analysis of the German Arthroplasty Registry","volume":"24","author":"Szymski,","year":"2023","journal-title":"J. Orthop. 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A New Zealand Joint Registry study","volume":"28","author":"Sharplin,","year":"2018","journal-title":"Hip Int."},{"issue":"1","key":"R6-59-20260326","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00264-018-4097-2","article-title":"The influence of bearing surfaces on periprosthetic hip infections: analysis of thirty nine thousand, two hundred and six cementless total hip arthroplasties","volume":"43","author":"Bordini,","year":"2019","journal-title":"Int. Orthop."},{"issue":"18","key":"R7-59-20260326","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.2106\/JBJS.K.01352","article-title":"Corrosion at the head-neck taper as a cause for adverse local tissue reactions after total hip arthroplasty","volume":"94","author":"Cooper,","year":"2012","journal-title":"J. Bone Joint Surg. Am."},{"issue":"2","key":"R8-59-20260326","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.artd.2016.11.006","article-title":"Inflammatory pseudotumor after ceramic-on-ceramic total hip arthroplasty","volume":"3","author":"Campbell,","year":"2017","journal-title":"Arthroplast Today."},{"issue":"5","key":"R9-59-20260326","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1097\/JS9.0000000000000373","article-title":"The SCARE 2023 guideline: updating consensus Surgical CAse REport (SCARE) guidelines","volume":"109","author":"Sohrabi,","year":"2023","journal-title":"Int J Surg Lond Engl."},{"key":"R10-59-20260326","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jor.2021.10.002","article-title":"Surgical management of hip prosthetic failure in metallosis: a case series and literature review","volume":"28","author":"Pisanu,","year":"2021","journal-title":"J. Orthop."},{"issue":"4","key":"R11-59-20260326","article-title":"The Italian Covid-19 phase 2 in Piacenza: results of the first semester of 2020 and future prospective of new orthopedics surgical procedures","volume":"91","author":"Maniscalco,","year":"2020","journal-title":"Acta Biomed"},{"issue":"14","key":"R12-59-20260326","article-title":"The impact of COVID-19 pandemic on the Emergency Room and Orthopedic Departments in Piacenza: a retrospective analysis","volume":"91","author":"Maniscalco,","year":"2020","journal-title":"Acta Biomed"},{"issue":"1","key":"R13-59-20260326","doi-asserted-by":"crossref","DOI":"10.1016\/j.otsr.2019.12.015","article-title":"No radiological and biological sign of trunnionosis with large diameter head ceramic bearing total hip arthroplasty after 5 years","volume":"107","author":"Eichler,","year":"2021","journal-title":"Orthop. Traumatol. Surg. Res."},{"issue":"1","key":"R14-59-20260326","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1186\/s12891-019-2722-x","article-title":"Severe wear and multiple pseudotumor formation due to revision for ceramic head breakage after ceramic-on-ceramic total hip arthroplasty: a case report","volume":"20","author":"Xing,","year":"2019","journal-title":"BMC Musculoskelet. Disord."},{"issue":"Suppl. 2","key":"R15-59-20260326","first-page":"1065","article-title":"Ceramic-on-metal coupling in THA: long term clinical and radiographic outcomes using two different short stems","volume":"22","author":"Logroscino,","year":"2021","journal-title":"BMC Musculoskelet. 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Traumatol."},{"issue":"11","key":"R19-59-20260326","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1007\/s00264-020-04686-8","article-title":"Neck modularity in total hip arthroplasty: a retrospective study of nine hundred twenty-eight titanium neck implants with a maximum follow-up of eighteen years","volume":"44","author":"Maniscalco,","year":"2020","journal-title":"Int. Orthop."},{"issue":"10","key":"R20-59-20260326","doi-asserted-by":"crossref","first-page":"865","DOI":"10.2106\/JBJS.L.01042","article-title":"Adverse local tissue reaction arising from corrosion at the femoral neck-body junction in a dual-taper stem with a cobalt-chromium modular neck","volume":"95","author":"Cooper,","year":"2013","journal-title":"J. Bone Joint Surg. 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