{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T16:57:01Z","timestamp":1774544221632,"version":"3.50.1"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T00:00:00Z","timestamp":1707782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Mucin hypersecretion promoted by intestinal metaplasia can lead to gallstone formation. The presence of large amounts of mucin induced by a change in biliary epithelium structure is called a mucocele, a usually benign condition studied among animals but rarely described in humans. This entity must be distinguished from hydrops, a condition secondary to an impacted gallstone in the cystic duct leading to an outlet obstruction and distension of the gallbladder.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Presentation of case:<\/jats:title>\n                    <jats:p>We report a case of a 51-year-old female with lithiasic cholecystitis showing areas of intestinal metaplasia associated with a mucocele. Laparoscopic cholecystectomy was performed with an uneventful postoperative course. Macroscopic findings revealed a dilated gallbladder filled with mucoid fluid. Signs of chronic and focally acute cholecystitis with areas of intestinal metaplasia were observed microscopically.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>Lithiasic gallbladders can bear a gene that is found in goblet cells of intestinal metaplasia, leading to mucin hypersecretion. Metaplasia - a benign lesion often encountered on cholecystectomy specimens - can be the precursor of carcinoma. Mucin-producing gallbladder carcinoma is a very aggressive tumor that can appear as a mucocele. Consequently, preoperative computed tomography or magnetic resonance cholangiopancreatography should be performed in the presence of an unusual aspect on sonography.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Metaplastic changes in gallbladder epithelium associated with an overproduction of mucin and lithiasic cholecystitis reported in this case is a rarity. Malignancy is an alternative diagnosis of gallbladder mucocele that must be suspected whenever preoperative imaging of the gallbladder is atypical.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2024.109405","type":"journal-article","created":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T03:33:22Z","timestamp":1708659202000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Gallbladder mucocele caused by intestinal metaplasia in lithiasic cholecystitis: A case report and literature review of a rare association"],"prefix":"10.1097","volume":"116","author":[{"given":"Marion","family":"Poget","sequence":"first","affiliation":[{"name":"Children and Adolescent Surgery Service, Lausanne University Hospital, Rue du Bugnon 46, CH-1011 Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vilma","family":"Salvatori Chappuis","sequence":"additional","affiliation":[{"name":"ADMED Pathology, Neuchatel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesc","family":"Carb\u00f3 Descamps","sequence":"additional","affiliation":[{"name":"ADMED Pathology, Neuchatel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alend","family":"Saadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"issue":"3","key":"R1-87-20260326","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1365-2559.1981.tb01788.x","article-title":"Inappropriate mucin production in gall bladder metaplasia and neoplasia - an immunohistological study","volume":"5","author":"De Boer,","year":"1981","journal-title":"Histopathology"},{"issue":"10","key":"R2-87-20260326","doi-asserted-by":"crossref","first-page":"834","DOI":"10.3126\/jpn.v5i10.15640","article-title":"Histological evaluation of 400 cholecystectomy specimens","volume":"5","author":"Kumar,","year":"2015","journal-title":"J Pathol Nepal"},{"issue":"242","key":"R3-87-20260326","first-page":"970","article-title":"Non-neoplastic lesions of gallbladder among cholecystectomy specimens of a tertiary care center: a descriptive cross-sectional study","volume":"59","author":"Ghartimagar,","year":"2021","journal-title":"JNMA J. 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