{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:09:54Z","timestamp":1786118994783,"version":"build-2736575974"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T00:00:00Z","timestamp":1708992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Graft versus host disease (GVHD) remains a significant source of morbidity and mortality in the setting of allogeneic stem cell transplantation. Skin involvement is reported to be as high as 70-95 % in this group with GVHD and the severity of the involvement varies widely. Surgical management of complications of severe cutaneous GVHD is uncommon and is rarely mentioned as a treatment option.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation:<\/jats:title>\n                    <jats:p>We present a case of severe sclerodermatous skin changes restricting chest expansion and exercise tolerance to the point of limiting basic activities of daily life. A 54-year-old male presents with severe restrictive lung disease from sclerodermatous graft versus host disease (GVHD) after stem cell transplant for Chronic Myeloid Leukaemia (CML). He experienced limited symptomatic relief from maximal medical therapy and photochemotherapy, and subsequently underwent a skin release and split skin grafting of his chest and abdomen in an effort to improve exercise tolerance and quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical discussion:<\/jats:title>\n                    <jats:p>Despite an initial improvement in functioning, the patient's spirometry and lung function continued to decline with time, possibly suggesting that he did not gain a sustained benefit from surgical release of his cutaneous GVHD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>While delineating between disease progression and surgical outcome is difficult in this case, the patient would argue that by delaying or reducing further decline in function, the surgical release procedures led to improved quality of life in subsequent years. However further research is required to establish a clear role for surgery in the treatment of refractory cutaneous GVHD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2024.109455","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T13:05:10Z","timestamp":1709816710000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Surgical release of the chest wall skin and fascia for sclerodermatous graft versus host disease causing restrictive lung disease: A case report"],"prefix":"10.1097","volume":"117","author":[{"given":"Mitchell","family":"Nash","sequence":"first","affiliation":[{"name":"Burns Unit, Concord Repatriation General Hospital, Concord, NSW 2137, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Cartwright","sequence":"additional","affiliation":[{"name":"Department of Haematology, Wollongong Hospital, Wollongong, NSW 2500, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Middleton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Maitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"1","key":"R1-10-20260423","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbmt.2005.11.003","article-title":"Graft-versus-host disease after allogeneic stem cell transplantation: evolving concepts and novel therapies including photopheresis","volume":"12","author":"Komanduri,","year":"2006","journal-title":"Biol. Blood Marrow Transplant."},{"issue":"4","key":"R2-10-20260423","doi-asserted-by":"crossref","first-page":"535.e1","DOI":"10.1016\/j.jaad.2011.11.961","article-title":"Skin signs of graft versus host disease","volume":"66","author":"Hymes,","year":"2013","journal-title":"J. Am. Dermatol."},{"issue":"8","key":"R3-10-20260423","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1038\/sj.bmt.1704436","article-title":"Extracorporeal photochemotherapy for treatment of fasciitis in chronic graft-versus-host disease","volume":"33","author":"Sbano,","year":"2004","journal-title":"Bone Marrow Transplant."},{"issue":"6","key":"R4-10-20260423","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/j.jaad.2008.08.023","article-title":"Rippled skin, fasciitis, and joint contractures","volume":"59","author":"P,","year":"2008","journal-title":"J. Am. Dermatol."},{"issue":"1","key":"R6-10-20260423","first-page":"305","article-title":"The levels of evidence and their role in evidence-based medicine","volume":"128","author":"Burns,","year":"2011"},{"issue":"10","key":"R7-10-20260423","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.bjps.2007.03.036","article-title":"Successful treatment of refractory joint contractures caused by sclerodermatous graft versus host disease","volume":"61","author":"Kim,","year":"2008","journal-title":"J. Plast. Reconstr. Aesthet. Surg."},{"issue":"5","key":"R8-10-20260423","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1097\/01241398-199809000-00002","article-title":"Orthopaedic manifestations of chronic graft-versus-host disease","volume":"18","author":"Beredjiklian,","year":"1998","journal-title":"J. Pediatr. Orthop."},{"issue":"5","key":"R9-10-20260423","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1097\/JS9.0000000000000373","article-title":"The SCARE 2023 guideline: updating consensus Surgical CAse REport (SCARE) guidelines","volume":"109","author":"Sohrabi,","year":"2023","journal-title":"Int. J. Surg. Lond. Engl."},{"issue":"5","key":"R10-10-20260423","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1097\/BCR.0b013e3181b47cd3","article-title":"Escharotomy and decompressive therapies in burns","volume":"30","author":"Orgill,","year":"2009","journal-title":"J. Burn Care Res."},{"issue":"2","key":"R11-10-20260423","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/jbcr\/irz152","article-title":"Surgical escharotomy and decompressive therapies in burns","volume":"41","author":"Caleb Butts,","year":"2020","journal-title":"J. Burn Care Res."},{"issue":"6","key":"R12-10-20260423","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.burns.2006.02.009","article-title":"An algorithm for the release of burn contractures of the extremities","volume":"32","author":"Hudson,","year":"2006","journal-title":"Burns"},{"issue":"3","key":"R13-10-20260423","doi-asserted-by":"crossref","first-page":"e153","DOI":"10.1097\/BCR.0000000000000106","article-title":"A systematic review on burn scar contracture treatment","volume":"36","author":"Stekelenburg,","year":"2015","journal-title":"J. Burn Care Res."}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261224002360?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261224002360?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ovid.com\/10.1016\/j.ijscr.2024.109455","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T17:30:42Z","timestamp":1786037442000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.1016\/j.ijscr.2024.109455"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":12,"journal-issue":{"issue":"C","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2024.109455","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"2024-01-29","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-26","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}