{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:11:07Z","timestamp":1786119067572,"version":"build-2736575974"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T00:00:00Z","timestamp":1709078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction and importance:<\/jats:title>\n                    <jats:p>Gastrointestinal stromal tumors (GISTs) are rare mesenchymal tumors with varied clinical presentations. This case report highlights the significance of recognizing atypical GIST presentations, such as hematemesis, especially in resource-limited settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation:<\/jats:title>\n                    <jats:p>A 52-year-old male from an economically disadvantaged background presented with hematemesis and severe anemia. Initial investigations suggested iron deficiency anemia, but further evaluation revealed a gastric mass, raising suspicion of GIST. Despite limited resources, a distal radical gastrectomy confirmed the GIST diagnosis, and the patient underwent surgical resection followed by imatinib therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical discussion:<\/jats:title>\n                    <jats:p>This case underscores the diagnostic challenges posed by GISTs and the importance of imaging studies, given their often nonspecific symptoms. Limited resources and economic constraints in low-income settings can hinder comprehensive diagnosis and treatment. Access to specialized oncological services is crucial for accurate management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Early recognition and management of GIST, even in atypical presentations like hematemesis, can significantly impact patient outcomes. This case report highlights the need for improved healthcare infrastructure in low-resource settings and calls for initiatives to ensure equitable access to diagnostic tests and appropriate treatment for rare diseases like GIST.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2024.109456","type":"journal-article","created":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T12:28:18Z","timestamp":1709555298000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["A rare case of gastro-intestinal stromal tumor presented with hematemesis and severe anemia from a low and middle-income country"],"prefix":"10.1097","volume":"117","author":[{"given":"Md. Saiful","family":"Islam","sequence":"first","affiliation":[{"name":"Department of Surgery, M Abdur Rahim Medical College hospital, Dinajpur, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhigan Babu","family":"Shrestha","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, M Abdur Rahim Medical College hospital, Dinajpur, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahmida","family":"Rimti","sequence":"additional","affiliation":[{"name":"Chittagong Medical College, Chattogram 4203, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suju","family":"Bhattarai","sequence":"additional","affiliation":[{"name":"Kathmandu Medical College and Teaching Hospital, Kathmandu, Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Raihan Kabir","family":"Ziko","sequence":"additional","affiliation":[{"name":"Department of Surgery, M Abdur Rahim Medical College hospital, Dinajpur, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barsha","family":"Pantha","sequence":"additional","affiliation":[{"name":"Department of Surgery, Post Graduation Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-11-20260423","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1111\/j.1582-4934.2006.tb00541.x","article-title":"Interstitial cells of Cajal (ICC) and gastrointestinal stromal tumor (GIST): facts, speculations, and myths","volume":"10","author":"Min,","year":"2006","journal-title":"J. Cell. Mol. Med."},{"key":"R2-11-20260423","first-page":"319","article-title":"Gastrointestinal stromal tumors: review on morphology, diagnosis and management","volume":"50","author":"F\u00fcl\u00f6p,","year":"2009","journal-title":"Romanian J. Morphol. Embryol."},{"key":"R3-11-20260423","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1002\/jso.21120","article-title":"A systematic review on the clinical diagnosis of gastrointestinal stromal tumors","volume":"98","author":"Scarpa,","year":"2008","journal-title":"J. Surg. Oncol."},{"key":"R4-11-20260423","doi-asserted-by":"crossref","first-page":"3972","DOI":"10.1245\/s10434-017-6087-9","article-title":"Rectal gastrointestinal stromal tumor (GIST) in the era of imatinib: organ preservation and improved oncologic outcome","volume":"24","author":"Cavnar,","year":"2017","journal-title":"Ann. Surg. Oncol."},{"issue":"5","key":"R5-11-20260423","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1097\/JS9.0000000000000373","article-title":"The SCARE 2023 guideline: updating consensus surgical CAse REport (SCARE) guidelines","volume":"109","author":"Sohrabi,","year":"2023","journal-title":"Int. J. Surg. Lond. Engl."},{"issue":"60","key":"R6-11-20260423","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.ijsu.2018.10.031","article-title":"Statement: updating consensus preferred reporting of CasE series in surgery (PROCESS) guidelines","volume":"2018","author":"Agha","year":"2018","journal-title":"Int. J. Surg."},{"key":"R7-11-20260423","article-title":"Tumores del estroma gastrointestinal (GIST), avances en el conocimiento y manejo. Gaceta Mexicana de","volume":"10","year":"2011","journal-title":"Oncolog\u00eda"},{"key":"R8-11-20260423","first-page":"162","article-title":"The epidemiology of malignant gastrointestinal stromal tumors: an analysis of 1,458 cases from 1992 to 2000.Am","volume":"100","author":"Tran,","year":"2005","journal-title":"J. Gastroenterol."},{"key":"R9-11-20260423","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1002\/cncr.20862","article-title":"Gastrointestinal stromal tumors: the incidence, prevalence, clinical course, and prognostication in the preimatinibmesylate era - a population-based study in western Sweden","volume":"103","author":"Nilsson,","year":"2005","journal-title":"Cancer"},{"key":"R10-11-20260423","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/j.humpath.2006.07.002","article-title":"High incidence of microscopic gastrointestinal stromal tumors in the stomach","volume":"37","author":"Kawanowa,","year":"2006","journal-title":"Hum. Pathol."},{"key":"R11-11-20260423","article-title":"Giant gastrointestinal stromal tumors of the stomach successfully treated with laparoscopic resection: case report and literature review","volume":"13","author":"Mohamed,","year":"2021","journal-title":"Cureus"},{"key":"R12-11-20260423","article-title":"A gastrointestinal stromal tumor with acute bleeding: management and nursing","volume":"97","author":"Shi,","year":"2018","journal-title":"Medicine"},{"issue":"5","key":"R13-11-20260423","first-page":"294","article-title":"Upper Gastrointestinal Bleeding in Adults: Evaluation and Management","volume":"101","author":"Wilkins","year":"2020","journal-title":"Am Fam Physician"},{"issue":"4","key":"R14-11-20260423","article-title":"Massive gastrointestinal haemorrhage unusual presentation of gastrointestinal stromal tumors of the jejunum: case report and literature review","volume":"13","author":"Mohamed,","year":"2021","journal-title":"Cureus"},{"issue":"3","key":"R15-11-20260423","first-page":"E61","article-title":"Gastrointestinal stromal tumour as a cause of hematemesis","volume":"51","author":"White,","year":"2008","journal-title":"Can. J. Surg."}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261224002372?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261224002372?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ovid.com\/10.1016\/j.ijscr.2024.109456","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T17:30:42Z","timestamp":1786037442000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.1016\/j.ijscr.2024.109456"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":15,"journal-issue":{"issue":"C","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2024.109456","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"2023-07-03","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-27","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}