{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T21:40:35Z","timestamp":1776980435488,"version":"3.51.4"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T00:00:00Z","timestamp":1709164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Krukenberg tumors account for 9 % of metastatic ovarian tumors, they usually originate from the stomach and colon and are microscopically characterized by the presence of mucus-filled signet-ring cells. Krukenberg tumor originating from the gastroesophageal junction is extremely rare, which limits establishing proper diagnosis and management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Presentation of case:<\/jats:title>\n                    <jats:p>A 34-year-old women presented with a complaint of amenorrhea, ultrasonography showed bilateral ovarian masses, pathological studies revealed Krukenberg tumor, immunohistochemistry of the tumor was positive for (CK1, and CK20). Upper GI endoscopy revealed the primary lesion located at the inferior esophagus and extending to the cardia. Despite marked improvement after introducing a chemotherapy regimen of oxaliplatin, calcium folinate and fluorouracil, the patient refused to complete her therapeutic course and died 5 months after discontinuation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>Krukenberg tumor may be asymptomatic but may also manifest as pelvic pain, bloating, and menstrual cycle abnormalities. Immunohistochemistry of Krukenberg tumor is mandatory to determine the primary tumor. Positivity of CK1, CK20 and negativity of CK7 indicates the gastrointestinal origin of the tumor. Different choices are available for the management of Krukenberg tumor but it still has a poor prognosis with an average survival rate of 14 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Krukenberg tumor from the esophagus is rare and still enigmatic in terms of management. In this article, we aim to draw attention into possible presentations of the tumor by providing the first case in Syria of Krukenberg tumor originating from the esophagus and presenting as secondary amenorrhea and bilateral adnexal masses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2024.109472","type":"journal-article","created":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T12:25:22Z","timestamp":1709295922000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Secondary amenorrhea as the first presentation of Krukenberg tumor arising from the gastroesophageal junction in a 34-year-old woman: A case report"],"prefix":"10.1097","volume":"117","author":[{"given":"Bassam","family":"Hassan","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Cancer Research Center, Tishreen University, Latakia, Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lava","family":"Abdullah","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Police Hospital, Damascus, Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Firas","family":"Hussein","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Tishreen University Hospital, Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alaghiad","family":"Issa","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Cancer Research Center, Tishreen University, Latakia, Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thanaa","family":"Al-Assi","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Alsaydeh Surgical Hospital, Latakia, Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuheir","family":"Alshehabi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"issue":"4","key":"R1-20-20260423","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.suronc.2017.09.001","article-title":"Krukenberg tumors: seed, route and soil","volume":"26","author":"Agnes,","year":"2017","journal-title":"Surg. 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