{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:09:25Z","timestamp":1786118965407,"version":"build-2736575974"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T00:00:00Z","timestamp":1714694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction and importance:<\/jats:title>\n                    <jats:p>Maxillomandibular involvement with brown tumours is rare, especially in the paediatric population. We present a rare case of a young girl with brown tumour (BT) occurring in the mandible as the first manifestation of hyperparathyroidism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation:<\/jats:title>\n                    <jats:p>A 7-year-old black female, presented with a 6-month history of a swelling on the left mandible. Patient had a history of intractable gastrointestinal symptoms such as nausea, vomiting and abdominal cramps. Biopsy confirmed the lesion as a giant cell lesion. Elevated parathyroid hormone (PTH) levels confirmed the diagnosis of a BT of hyperparathyroidism. The patient underwent surgical intervention involving parathyroidectomy. This was followed by segmental resection of the mandibular tumour two years later.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical discussion:<\/jats:title>\n                    <jats:p>Brown Tumour is a rare, non-neoplastic lesion resulting from abnormal bone metabolism secondary to hyperparathyroidism. BT predominantly arise in long bones and the axial skeleton. Maxillomandibular involvement is very rare. In the present case, after parathyroidectomy, normal PTH and calcium levels were restored, and there was relief of gastrointestinal tract hypercalcaemic symptoms. However, there was no spontaneous regression of the mandibular tumour over a 2-year observation period. Hemimandibulectomy followed by reconstruction with a plate and costochondral graft was then performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>It is difficult to differentiate BT from other giant cell lesions without blood chemistry revealing hyperparathyroidism. The distinction is imperative to avoid mutilating and aggressive treatment for BTs. Although BTs are amenable for conservative treatment, the present case illustrates that for bigger tumours, in the absence of spontaneous regression, aggressive surgical treatment may be required.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2024.109735","type":"journal-article","created":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T12:41:30Z","timestamp":1715172090000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Lytic brown tumour of the mandible as the initial presentation of hyperparathyroidism in a 7-year old girl: A case report"],"prefix":"10.1097","volume":"119","author":[{"given":"Risimati Ephraim","family":"Rikhotso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faheema","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"2","key":"R2-76-20260422","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.cxom.2017.04.011","article-title":"Head and neck manifestations of endocrine disorders","volume":"25","author":"Farag","year":"2017","journal-title":"Atlas Oral Maxillofac. Surg. Clin. North Am."},{"issue":"4","key":"R3-76-20260422","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.anorl.2018.03.005","article-title":"Maxillofacial brown tumours: series of 5 cases","volume":"135","author":"Antin","year":"2018","journal-title":"Eur. Ann. Otorhinolaryngol. Head Neck Dis."},{"issue":"4","key":"R4-76-20260422","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.coms.2017.06.005","article-title":"Controversies in oral and maxillofacial pathology","volume":"29","author":"Peacock","year":"2017","journal-title":"Oral Maxillofac. Surg. Clin. North Am."},{"issue":"5","key":"R5-76-20260422","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1097\/JS9.0000000000000373","article-title":"The SCARE 2023 guideline: updating consensus surgical CAse REport (SCARE) guidelines","volume":"109","author":"Sohrabi","year":"2023","journal-title":"Int J Surg Lond Engl."},{"issue":"25","key":"R6-76-20260422","article-title":"Malignant mimic: Brown tumours of primary hyperparathyroidism","volume":"1","author":"Mansfield","year":"2022","journal-title":"Journal of Clinical and Translational Endocrinology: Case Reports."},{"issue":"4","key":"R7-76-20260422","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1097\/MAJ.0000000000000441","article-title":"Skeletal lesions in primary hyperparathyroidism","volume":"349","author":"Yang","year":"2015","journal-title":"Am J Med Sci"},{"issue":"5","key":"R8-76-20260422","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1359\/jbmr.1997.12.5.856","article-title":"Primary hyperparathyroidism: still evolving?","volume":"12","author":"Silverberg","year":"1997","journal-title":"J. Bone Miner. Res."},{"key":"R9-76-20260422","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1007\/s12020-017-1414-2","article-title":"Osteitis fibrosa cystica\u2014a forgotten radiological feature of primary hyperparathyroidism","volume":"58","author":"Misiorowski","year":"2017","journal-title":"Endocr"},{"issue":"12","key":"R10-76-20260422","doi-asserted-by":"crossref","first-page":"2988","DOI":"10.1002\/1097-0142(19921215)70:12<2988::AID-CNCR2820701242>3.0.CO;2-V","article-title":"The WHO histological typing of odontogenic tumours. A commentary on the second edition","volume":"70","author":"Kramer","year":"1992","journal-title":"Cancer"},{"key":"R11-76-20260422","first-page":"2015","article-title":"Mandibular brown tumor of secondary hyperparathyroidism requiring extensive resection: a forgotten entity in the developed world?","volume":"19","author":"Qaisi","year":"2015","journal-title":"Case Rep. Med."},{"issue":"2","key":"R12-76-20260422","doi-asserted-by":"crossref","first-page":"244","DOI":"10.4103\/jomfp.JOMFP_60_17","article-title":"Alteration of cellular metabolism in cancer cells and its therapeutic prospects","volume":"21","author":"Biswal","year":"2017","journal-title":"J Oral Maxillofac Pathol."},{"key":"R13-76-20260422","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s10354-013-0235-z","article-title":"Clinical aspects of primary hyperparathyroidism: clinical manifestations, diagnosis, and therapy","volume":"163","author":"Gasser","year":"2013","journal-title":"Wien. Med. Wochenschr."},{"issue":"2","key":"R14-76-20260422","first-page":"260","article-title":"Brown tumors of the anterior skull base as the initial manifestation of true normocalcemic primary hyperparathyroidism: report of three cases and review of the literature","volume":"23","author":"Khalatbari","year":"2013","journal-title":"Turk. Neurosurg."},{"issue":"2","key":"R15-76-20260422","first-page":"86","article-title":"L\u00e9sions \u00e0 cellules g\u00e9antes des maxillaires r\u00e9v\u00e9latrices d'hyperparathyro\u00efdie primaire","volume":"101","author":"Aoune","year":"2000","journal-title":"Rev. Stomatol. Chir. Maxillofac."},{"issue":"2","key":"R16-76-20260422","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/nrendo.2017.104","article-title":"Primary hyperparathyroidism","volume":"14","author":"Walker","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"issue":"1057","key":"R17-76-20260422","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1136\/postgradmedj-2012-131707","article-title":"Characteristics, management and outcome of primary hyperparathyroidism in South Africa: a single-Centre experience","volume":"89","author":"Paruk","year":"2013","journal-title":"Postgrad. Med. J."},{"issue":"3","key":"R18-76-20260422","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1210\/jc.2012-4022","article-title":"Incidence and prevalence of primary hyperparathyroidism in a racially mixed population","volume":"98","author":"Yeh","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"Suppl. 1","key":"R19-76-20260422","first-page":"S59","article-title":"Multifocal osteolytic lesions of jaw as a road map to diagnosis of brown tumor of hyperparathyroidism: a rare case report with review of literature","volume":"24","author":"Gosavi","year":"2020","journal-title":"J Oral Maxillofac Pathol."},{"key":"R20-76-20260422","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00784-017-2124-0","article-title":"Systematic review of oral manifestations related to hyperparathyroidism","volume":"22","author":"Palla","year":"2018","journal-title":"Clin. Oral Investig."},{"key":"R21-76-20260422","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1556\/1647.2023.00134","article-title":"Visualizing hyperparathyroidism: a pictorial essay of Tc-99m MIBI parathyroid imaging across different aetiologies","volume":"15","author":"Buakhao","year":"2023","journal-title":"Imaging"},{"issue":"20","key":"R22-76-20260422","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000025968","article-title":"Primary hyperparathyroidism presenting as a brown tumor with hypercalcemia crisis in a second-trimester pregnant woman: a case report","volume":"100","author":"Xu","year":"2021","journal-title":"Medicine"},{"key":"R23-76-20260422","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1007\/s00198-019-04921-y","article-title":"Hypophosphatasia: Canadian update on diagnosis and management","volume":"30","author":"Khan","year":"2019","journal-title":"Osteoporos. Int."},{"issue":"5","key":"R24-76-20260422","first-page":"377","article-title":"Hypercalcemia and cancer: differential diagnosis and treatment","volume":"68","author":"Zagzag","year":"2018","journal-title":"CA Cancer J. Clin."},{"issue":"1","key":"R25-76-20260422","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/dc.23631","article-title":"Brown tumor of hyperparathyroidism","volume":"45","author":"Agnihotri","year":"2016","journal-title":"Diagn. Cytopathol."},{"issue":"10","key":"R26-76-20260422","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1016\/j.joms.2017.03.013","article-title":"Hyperparathyroidism diagnosed due to brown tumors of the jaw: a case report and literature review","volume":"75","author":"Brabyn","year":"2017","journal-title":"J. Oral Maxillofac. Surg."},{"key":"R27-76-20260422","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.ijom.2006.02.011","article-title":"Limited regression of central giant cell granuloma by interferon alpha after failed calcitonin therapy: a report of 2 cases","volume":"35","author":"De Lange","year":"2006","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"R28-76-20260422","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.ijscr.2015.02.001","article-title":"Injection of steroids intralesional in central giant cell granuloma cases (giant cell tumour): is it free of systemic complications or not? A case report","volume":"8","author":"El Hadidi","year":"2015","journal-title":"Int. J. Surg. Case Rep."},{"key":"R29-76-20260422","doi-asserted-by":"crossref","first-page":"102","DOI":"10.4103\/2231-0746.101325","article-title":"The diagnosis and management of giant cell lesions of the jaws","volume":"2","author":"Pogrel","year":"2012","journal-title":"Ann Maxillofac Surg."},{"key":"R30-76-20260422","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0266-4356(93)90168-V","article-title":"Central giant cell granulomas of the jaws regress with calcitonin therapy","volume":"31","author":"Harris","year":"1993","journal-title":"Br. J. Oral Maxillofac. Surg."}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261224005169?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261224005169?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ovid.com\/10.1016\/j.ijscr.2024.109735","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T17:11:09Z","timestamp":1786036269000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.1016\/j.ijscr.2024.109735"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":29,"journal-issue":{"issue":"C","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2024.109735","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"2024-03-20","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-02","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}