{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:10:02Z","timestamp":1786119002021,"version":"build-2736575974"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T00:00:00Z","timestamp":1715040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction and importance:<\/jats:title>\n                    <jats:p>Gastrointestinal stromal tumors (GISTs) are rare mesenchymal neoplasms predominantly affecting the gastrointestinal tract. While they often remain asymptomatic, GISTs can lead to acute abdominal emergencies, such as peritonitis secondary to tumor perforation, a rare yet serious complication. Here, we present a unique case of a locally advanced ileal gastrointestinal stromal tumor complicated by generalized purulent peritonitis, emphasizing the diagnostic and management challenges associated with this condition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation:<\/jats:title>\n                    <jats:p>A 68-year-old male presented with worsening abdominal pain, vomiting, fever, and weight loss. Imaging studies revealed a large solid-cystic mass originating from the terminal ileum, prompting emergency surgery. Intraoperative findings included a multilobulated tumor mass invading the mesocolon, necessitating hemicolectomy. Histopathological analysis confirmed a high-risk gastrointestinal stromal tumor, leading to initiation of adjuvant therapy with imatinib mesylate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical discussion:<\/jats:title>\n                    <jats:p>GISTs often present with nonspecific symptoms, posing diagnostic challenges. Peritonitis secondary to tumor perforation is a rare yet critical complication requiring prompt surgical intervention. Complete resection remains the mainstay of treatment, with adjuvant imatinib therapy showing promise in high-risk cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This case report sheds light on the complexities of diagnosing and managing locally advanced gastrointestinal stromal tumors (GISTs) complicated by peritonitis. Complete tumor resection is crucial for potential cure, with adjuvant therapy using imatinib showing promise, especially in high-risk cases. Thorough diagnostic assessment, timely intervention, and comprehensive follow-up are essential for optimizing outcomes in complex GIST presentations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2024.109739","type":"journal-article","created":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T22:17:51Z","timestamp":1715206671000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["A case report: Peritonitis secondary to perforated locally advanced gastrointestinal stromal tumor"],"prefix":"10.1097","volume":"119","author":[{"given":"Hager","family":"Behi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Omry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanene","family":"Guelmami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amel","family":"Changuel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal","family":"Kamtaoui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Med Bachir","family":"Khalifa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-79-20260422","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.ijscr.2014.12.012","article-title":"Peritonitis secondary to spontaneous perforation of a primary gastrointestinal stromal tumour of the small intestine: a case report and a literature review","volume":"6","author":"Alessiani","year":"2015","journal-title":"Int. J. Surg. Case Rep."},{"key":"R2-79-20260422","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ijscr.2018.05.012","article-title":"A gastrointestinal stromal tumor of the jejunum presenting with an intratumoral abscess: a case report and a literature review","volume":"48","author":"Ito","year":"2018","journal-title":"Int. J. Surg. Case Rep."},{"key":"R3-79-20260422","first-page":"3","article-title":"Malignant gastrointestinal stromal tumor of the sigmoid colon with perforation and peritonitis - an unusual presentation","author":"Jagtap","year":"2012","journal-title":"Int. J. Health Sci."},{"issue":"4","key":"R4-79-20260422","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1007\/s005950170159","article-title":"A spontaneously ruptured gastric stromal tumor presenting as generalized peritonitis: report of a case","volume":"31","author":"Kitabayashi","year":"2001","journal-title":"Surg. Today"},{"issue":"5","key":"R5-79-20260422","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1097\/JS9.0000000000000373","article-title":"The SCARE 2023 guideline: updating consensus Surgical CAse REport (SCARE) guidelines","volume":"109","author":"Sohrabi","year":"2023","journal-title":"Int. J. Surg."},{"key":"R6-79-20260422","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.ijscr.2017.08.041","article-title":"Acute diffuse peritonitis due to spontaneous rupture of a primary gastrointestinal stromal tumor of the jejunum: a case report","volume":"39","author":"Sato","year":"2017","journal-title":"Int. J. Surg. Case Rep."},{"key":"R7-79-20260422","article-title":"Paramythiotis. Perforated gastrointestinal stromal tumor of the small intestine: a case report presenting with peritonitis","year":"2011","journal-title":"J Curr Surg"},{"issue":"39","key":"R8-79-20260422","doi-asserted-by":"crossref","first-page":"6096","DOI":"10.3748\/wjg.14.6096","article-title":"Perforation of the colon by invading recurrent gastrointestinal stromal tumors during sunitinib treatment","volume":"14","author":"Hur","year":"2008","journal-title":"WJG"},{"issue":"1","key":"R9-79-20260422","doi-asserted-by":"crossref","first-page":"144","DOI":"10.21037\/jgo.2018.08.20","article-title":"Gastrointestinal stromal tumors: a comprehensive review","volume":"10","author":"Parab","year":"2018","journal-title":"J Gastrointest Oncol."},{"key":"R10-79-20260422","article-title":"Multiple gastrointestinal stromal tumors of the small intestine discovered in a context of peritonitis","volume":"33","author":"Dondo","year":"2019","journal-title":"Pan Afr Med J"},{"issue":"2","key":"R11-79-20260422","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1177\/106689690201000201","article-title":"Diagnosis of gastrointestinal stromal tumors: a consensus approach","volume":"10","author":"Fletcher","year":"2002","journal-title":"Int. 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Pathol."}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261224005200?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261224005200?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ovid.com\/10.1016\/j.ijscr.2024.109739","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T17:10:53Z","timestamp":1786036253000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.1016\/j.ijscr.2024.109739"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":11,"journal-issue":{"issue":"C","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2024.109739","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"2024-03-31","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-03","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}