{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:08:03Z","timestamp":1786118883089,"version":"build-2736575974"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T00:00:00Z","timestamp":1715817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction and importance:<\/jats:title>\n                    <jats:p>Tuberculosis (TB) remains a significant global health concern, particularly in low-income countries like Tunisia, despite advancements in healthcare and antibiotic accessibility. Gastrointestinal tuberculosis, although rare, can affect various parts of the gastrointestinal tract, with perianal involvement being exceptionally uncommon. We present a case of isolated perianal tuberculosis, emphasizing the complexities in diagnosis and management. In this context, we present a case of isolated perianal tuberculosis in a 51-year-old male, highlighting the diagnostic challenges and emphasizing the need for early recognition and comprehensive management strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation:<\/jats:title>\n                    <jats:p>A 51-year-old male presented with recurrent anal pain and purulent perianal discharge, without respiratory or gastrointestinal symptoms. Physical examination revealed indurated ulceration and fistulas, suggestive of recurrent anal fistulas. Biopsy and culture confirmed the diagnosis of isolated perianal tuberculosis, with no pulmonary or gastrointestinal involvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical discussion:<\/jats:title>\n                    <jats:p>Perianal tuberculosis presents unique challenges in diagnosis and management, often mimicking other conditions like Crohn's disease. Differential diagnosis requires a multidisciplinary approach, including biopsy, acid-fast staining, polymerase chain reaction, and cultures. Successful management involves a combination of surgical intervention and antituberculous therapy, yielding favorable outcomes with minimal recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Early recognition and comprehensive management are crucial in isolated perianal tuberculosis to prevent recurrence and unnecessary surgical interventions. This case underscores the importance of considering tuberculosis in the differential diagnosis of perianal pathologies, particularly in TB-endemic regions like Tunisia. Prompt initiation of appropriate therapy is essential for favorable patient outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2024.109770","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T07:21:51Z","timestamp":1715930511000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Diagnostic and therapeutic challenges in isolated perianal tuberculosis: A case report and comprehensive management overview"],"prefix":"10.1097","volume":"119","author":[{"given":"Anis","family":"Belhaj","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Omry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Med Dheker","family":"Touati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Med Raouf Ben","family":"Othmane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Saidani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faouzi","family":"Chebbi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"1","key":"R1-105-20260422","doi-asserted-by":"crossref","DOI":"10.1016\/j.bjid.2022.102722","article-title":"Primary extensive perianal cutaneous tuberculosis: a challenging diagnosis. Case report and a review of the literature","volume":"27","author":"Takahashi","year":"2023","journal-title":"Braz. J. Infect. Dis."},{"key":"R2-105-20260422","first-page":"1","article-title":"Perianal tuberculosis: a case report and a review of the literature","volume":"2012","author":"Ibn Majdoub Hassani","year":"2012","journal-title":"Case Rep. Infect. Dis."},{"issue":"12","key":"R3-105-20260422","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1093\/ecco-jcc\/jjv164","article-title":"Clinical features of tuberculous versus Crohn's anal fistulas, in Korea","volume":"9","author":"Choi","year":"2015","journal-title":"ECCOJC"},{"issue":"7","key":"R4-105-20260422","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1007\/s11605-021-04907-4","article-title":"Perianal tuberculosis","volume":"25","author":"Lip","year":"2021","journal-title":"J. Gastrointest. Surg."},{"issue":"5","key":"R5-105-20260422","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1097\/JS9.0000000000000373","article-title":"The SCARE 2023 guideline: updating consensus surgical CAse REport (SCARE) guidelines","volume":"109","author":"Sohrabi","year":"2023","journal-title":"Int. J. Surg."},{"key":"R6-105-20260422","first-page":"3","article-title":"Isolated Perianal Tuberculosis","volume":"63","author":"Akgun","year":"2005"},{"key":"R7-105-20260422","first-page":"64","article-title":"Perianal tuberculosis in a male patient with diabetes mellitus","volume":"20","author":"K\u0131l\u0131\u00e7","year":"2017","journal-title":"Turk. J. Fam. Med. Prim. Care"},{"key":"R8-105-20260422","article-title":"Tubercular Fistula-in-Ano","volume":"18","author":"Bokhari","year":"2008"},{"issue":"9","key":"R9-105-20260422","doi-asserted-by":"crossref","first-page":"848","DOI":"10.12998\/wjcc.v3.i9.848","article-title":"Perianal tuberculosis: a case report and review of the literature","volume":"3","author":"Tago","year":"2015","journal-title":"WJCC"},{"issue":"6","key":"R10-105-20260422","doi-asserted-by":"crossref","first-page":"e36","DOI":"10.1016\/j.ijsu.2006.11.005","article-title":"Anal tuberculosis: report of a case and review of literature","volume":"6","author":"Mathew","year":"2008","journal-title":"Int. J. Surg."},{"issue":"6","key":"R11-105-20260422","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1007\/s00384-014-2049-x","article-title":"Tuberculosis: a perennial pain in the posterior?","volume":"30","author":"Yim","year":"2015","journal-title":"Int. J. Colorectal Dis."},{"issue":"1","key":"R12-105-20260422","first-page":"17","article-title":"Perianal tuberculosis: an unusual clinical presentation","volume":"2","author":"Giridharan","year":"2020","journal-title":"Int. J. Case Rep. 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