{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:21:59Z","timestamp":1786990919226,"version":"build-2736575974"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T00:00:00Z","timestamp":1717459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Pseudoangiomatous stromal hyperplasia (PASH) is a rare breast stromal lesion that typically manifests clinically as a palpable unilateral, painless lump that is freely movable and has a rubbery or firm consistency. The diagnosis can be confirmed by a core needle biopsy (CNB) or surgical excision. Treatment options include medical treatment with hormonal management for asymptomatic patients or local excision and breast reduction in rare cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation:<\/jats:title>\n                    <jats:p>We reported the case of a 24-year-old woman with a history of taking contraceptive pills for about a year. Examination revealed extremely enlarged, sore, and swollen breasts, particularly the right side, marking her third PASH relapse. The patient underwent a surgical skin-reducing mastectomy (SRM) using a novel technique with an immediate prepectoral implant covered by a dermal flap to reconstruct the breast shape due to the large PASH lesions and aiming for optimal cosmetic outcomes. The procedure was complication-free with no recurrence after 18 months of follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>Mastectomy followed by immediate implantation offers benefits such as prompt restoration of breast shape with fewer surgeries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This case report highlights the successful use of immediate implantation in reconstructing large recurrent benign breast diseases. The outcomes indicate that immediate implantation shows promise as a suitable choice for carefully selected patients managing large, relapsing bilateral benign breast diseases. However, due to common complications such as infection and implant loss, it is not generally recommended for benign lesions. The decision should be made on a case-by-case basis, considering the size, recurrence, and individual suitability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2024.109873","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T12:08:38Z","timestamp":1717675718000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Innovative technique for managing extreme relapsing bilateral pseudoangiomatous stromal hyperplasia (PASH) in a young woman: A case report highlighting a novel intervention in reconstruction"],"prefix":"10.1097","volume":"120","author":[{"given":"Yeganeh","family":"Pakbaz","sequence":"first","affiliation":[{"name":"Breast Health & Cancer Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parisa","family":"Hoseinpour","sequence":"additional","affiliation":[{"name":"Department of Pathology, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faranak","family":"Olamaeian","sequence":"additional","affiliation":[{"name":"Breast Health & Cancer Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahid","family":"Nafissi","sequence":"additional","affiliation":[{"name":"Breast Health & Cancer Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"2","key":"R1-92-20260325","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1159\/000331612","article-title":"Nodular pseudoangiomatous stromal hyperplasia of the breast. Cytologic features","volume":"42","author":"Vicandi,","year":"1998","journal-title":"Acta Cytol."},{"issue":"2","key":"R2-92-20260325","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0046-8177(86)80292-1","article-title":"Pseudoangiomatous hyperplasia of mammary stroma","volume":"17","author":"Vuitch,","year":"1986","journal-title":"Hum. Pathol."},{"issue":"4","key":"R3-92-20260325","doi-asserted-by":"crossref","first-page":"331","DOI":"10.2325\/jbcs.12.331","article-title":"Nodular pseudoangiomatous stromal hyperplasia of mammary stroma in a case showing rapid tumor growth","volume":"12","author":"Taira,","year":"2005","journal-title":"Breast Cancer"},{"issue":"2","key":"R4-92-20260325","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/modpathol.3801003","article-title":"Pseudoangiomatous stromal hyperplasia tumor: a clinical, radiologic and pathologic study of 26 cases","volume":"21","author":"Ferreira,","year":"2008","journal-title":"Mod. Pathol."},{"key":"R6-92-20260325","doi-asserted-by":"crossref","DOI":"10.21037\/tbcr-21-37","article-title":"Pseudoangiomatous stromal hyperplasia causing massive unilateral breast enlargement\u2014a case report","volume":"3","author":"Brodie,","year":"2022","journal-title":"Transl. Breast Cancer Res."},{"issue":"1","key":"R7-92-20260325","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1148\/radiology.198.1.8539361","article-title":"Pseudoangiomatous stromal hyperplasia: mammographic, sonographic, and clinical patterns","volume":"198","author":"Cohen,","year":"1996","journal-title":"Radiology"},{"issue":"4","key":"R8-92-20260325","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.mayocp.2014.02.004","article-title":"Diagnosis and management of benign, atypical, and indeterminate breast lesions detected on core needle biopsy","volume":"89","author":"Neal,","year":"2014","journal-title":"Mayo Clin. Proc."},{"issue":"7","key":"R9-92-20260325","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.asjsur.2019.09.008","article-title":"Optimal treatment of pseudoangiomatous stromal hyperplasia of the breast","volume":"43","author":"Yoon,","year":"2020","journal-title":"Asian J. Surg."},{"issue":"3","key":"R10-92-20260325","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1097\/00000478-199503000-00004","article-title":"Pseudoangiomatous stromal hyperplasia (PASH). A mammary stromal tumor with myofibroblastic differentiation","volume":"19","author":"Powell,","year":"1995","journal-title":"Am. J. Surg. Pathol."},{"issue":"4","key":"R11-92-20260325","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/j.1445-2197.2011.05688.x","article-title":"Pseudoangiomatous stromal hyperplasia of the breast: an unusual pathology necessitating bilateral mastectomy during pregnancy","volume":"81","author":"Prichard,","year":"2011","journal-title":"ANZ J. Surg."},{"issue":"2","key":"R12-92-20260325","doi-asserted-by":"crossref","first-page":"218","DOI":"10.5999\/aps.2016.43.2.218","article-title":"Pseudoangiomatous stromal hyperplasia presenting as rapidly growing bilateral breast enlargement refractory to surgical excision","volume":"43","author":"Lee,","year":"2016","journal-title":"Arch. Plast. Surg."},{"issue":"3","key":"R13-92-20260325","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1097\/01.prs.0000233024.08392.14","article-title":"Skin-reducing mastectomy","volume":"118","author":"Nava,","year":"2006","journal-title":"Plast. Reconstr. Surg."},{"key":"R14-92-20260325","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/s13046-015-0227-5","article-title":"Skin-reducing mastectomy and immediate breast reconstruction in patients with macromastia","volume":"34","author":"De Vita,","year":"2015","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"6","key":"R15-92-20260325","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1097\/PRS.0000000000002227","article-title":"Skin-reduction breast reconstructions with prepectoral implant","volume":"137","author":"Caputo,","year":"2016","journal-title":"Plast. Reconstr. Surg."},{"issue":"1-2","key":"R16-92-20260325","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/ans.12570","article-title":"Breast reconstruction using de-epithelialized dermal flap after vertical-pattern skin-sparing mastectomy in macromastia","volume":"85","author":"Peker,","year":"2015","journal-title":"ANZ J. Surg."},{"issue":"6","key":"R17-92-20260325","first-page":"606","article-title":"Mastectomy and immediate breast reconstruction using a prosthesis and lower dermal flap: description of five cases","volume":"57","author":"Clerico,","year":"2012","journal-title":"Ann. Chir. Plast. Esthet."},{"issue":"5","key":"R18-92-20260325","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1097\/PRS.0000000000007899","article-title":"Skin-reducing mastectomy with immediate prepectoral reconstruction: surgical, aesthetic, and patient-reported outcomes with and without dermal matrices","volume":"147","author":"Safran,","year":"2021","journal-title":"Plast. Reconstr. Surg."},{"issue":"5","key":"R19-92-20260325","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1097\/JS9.0000000000000373","article-title":"The SCARE 2023 guideline: updating consensus Surgical CAse REport (SCARE) guidelines","volume":"109","author":"Sohrabi,","year":"2023","journal-title":"Int. J. Surg."},{"issue":"5","key":"R20-92-20260325","doi-asserted-by":"crossref","first-page":"630","DOI":"10.5999\/aps.2015.42.5.630","article-title":"Treatment of pseudoangiomatous stromal hyperplasia of the breast: implant-based reconstruction with a vascularized dermal sling","volume":"42","author":"Jung,","year":"2015","journal-title":"Arch. Plast. Surg."}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261224006540?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261224006540?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2024.109873","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T10:21:07Z","timestamp":1774434067000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2024.109873"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":19,"journal-issue":{"issue":"C","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2024.109873","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"2024-03-15","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-03","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}