{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T13:10:07Z","timestamp":1774444207782,"version":"3.50.1"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T00:00:00Z","timestamp":1721088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction and importance:<\/jats:title>\n                    <jats:p>Adrenal myelolipoma (AML) is a rare, benign neoplasm of the adrenal gland often found incidentally during medical examinations for unrelated conditions. This case study presents a 39-year-old male patient with a particularly large AML, weighing 11 kg upon surgical removal, potentially making it the largest documented tumor in medical literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation:<\/jats:title>\n                    <jats:p>A 39-year-old male presenting with abdominal distension and clinical manifestations of Cushing syndrome was discovered to have sizable adrenal masses. Initial pre-operative fine-needle aspiration biopsy indicated lipogenic tumors, however, subsequent post-operative pathological analysis revealed the presence of adrenal myelolipoma. Following surgery, the patient developed an adrenal crisis but responded well to glucocorticoid therapy and made a successful recovery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical discussion:<\/jats:title>\n                    <jats:p>In contrast to previously documented instances, the present case potentially the most extensive case of its kind reported thus far. AML is an uncommon benign tumor of the adrenal gland, with diagnostic and therapeutic challenges arising from its resemblance to other adrenal neoplasms. Owing to the inherent limitations of fine needle biopsy and the propensity for misdiagnosis, the adrenal origin of the tumor was not initially considered, leading to postoperative adrenal crisis in the patient.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>AML, a rare tumor, poses challenges in accurate diagnosis. Comprehensive imaging studies are essential to differentiate it from other neoplasms. Rigorous preoperative and postoperative pathological evaluations are crucial to avoid diagnostic errors. Additionally, thorough endocrinological assessments before and after surgery are imperative for early detection and management of any associated endocrine abnormalities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2024.110045","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T21:02:43Z","timestamp":1721768563000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Incidentally findings of bilateral giant adrenal myelolipoma: Case report"],"prefix":"10.1097","volume":"122","author":[{"given":"Qin","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Fuzhou First General Hospital affiliated with Fujian Medical University, Fuzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuekai","family":"You","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Fuzhou First General Hospital affiliated with Fujian Medical University, Fuzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingzhen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Fuzhou First General Hospital affiliated with Fujian Medical University, Fuzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Fuzhou First General Hospital affiliated with Fujian Medical University, Fuzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-16-20260325","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s12020-017-1473-4","article-title":"Adrenal myelolipoma: a comprehensive review","volume":"59","author":"Decmann,","year":"2018","journal-title":"Endocrine"},{"key":"R2-16-20260325","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s12020-017-1410-6","article-title":"The radiographically diagnosed adrenal myelolipoma: what do we really know?","volume":"58","author":"Campbell,","year":"2017","journal-title":"Endocrine"},{"key":"R3-16-20260325","doi-asserted-by":"crossref","DOI":"10.1148\/rg.220191","article-title":"Adrenal neoplasms: lessons from adrenal multidisciplinary tumor boards","volume":"43","author":"Chung,","year":"2023","journal-title":"Radiographics"},{"key":"R4-16-20260325","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/S2213-8587(21)00178-9","article-title":"Adrenal myelolipomas","volume":"9","author":"Calissendorff,","year":"2021","journal-title":"Lancet Diabetes Endocrinol."},{"key":"R5-16-20260325","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1097\/JS9.0000000000000373","article-title":"The SCARE 2023 guideline: updating consensus Surgical CAse REport (SCARE) guidelines","volume":"109","author":"Sohrabi,","year":"2023","journal-title":"Int. J. Surg."},{"key":"R6-16-20260325","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1136\/jcp.54.9.707","article-title":"Adrenal lipomatous tumours: a 30 year clinicopathological experience at a single institution","volume":"54","author":"Lam,","year":"2001","journal-title":"J. Clin. Pathol."},{"key":"R7-16-20260325","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/S2213-8587(20)30314-4","article-title":"Epidemiology of adrenal tumours in Olmsted County, Minnesota, USA: a population-based cohort study","volume":"8","author":"Ebbehoj,","year":"2020","journal-title":"Lancet Diabetes Endocrinol."},{"key":"R8-16-20260325","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/cen.14188","article-title":"Clinical course of adrenal myelolipoma: a long-term longitudinal follow-up study","volume":"93","author":"Hamidi,","year":"2020","journal-title":"Clin. Endocrinol."},{"key":"R9-16-20260325","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1210679","article-title":"Bilateral adrenal giant medullary lipoma combined with disorders of sex development: a rare case report and literature review","volume":"13","author":"Zhanghuang,","year":"2023","journal-title":"Front. Oncol."},{"key":"R10-16-20260325","doi-asserted-by":"crossref","first-page":"3186","DOI":"10.1016\/j.mayocp.2021.10.007","article-title":"Adrenal myelolipoma","volume":"96","author":"Erickson,","year":"2021","journal-title":"Mayo Clin. Proc."},{"key":"R11-16-20260325","doi-asserted-by":"crossref","first-page":"E637","DOI":"10.5489\/cuaj.422","article-title":"Pathologic analysis, diagnosis and treatment of adrenal myelolipoma","volume":"8","author":"Su,","year":"2014","journal-title":"Can. Urol. Assoc. 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