{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T18:58:42Z","timestamp":1783018722972,"version":"3.54.6"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:00:00Z","timestamp":1723075200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction and importance:<\/jats:title>\n                    <jats:p>Metastatic cancer of the umbilicus is an uncommon and rare presentation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation:<\/jats:title>\n                    <jats:p>Our interest for the clinical outcomes of umbilical metastases from colon cancer arose after a 60-years old lady with ulcerated umbilical lesion came to our clinic. She was seen in several other clinics, and the diagnoses of infection of the umbilical region and\/or of umbilical hernia were made. She was asymptomatic and in good clinical conditions. A complete evaluation led to the diagnosis of adenocarcinoma in the caecum with umbilical metastasis. During the hospital admission she underwent emergency colectomy for acute obstruction. An uneventful right colectomy was performed, but the lady died 21 months after surgery for diffuse metastases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical discussion:<\/jats:title>\n                    <jats:p>We performed a literature review of reports describing patients with umbilical metastases. Median survival rate was 7 months from the time of diagnosis of the umbilical metastasis (5 months in clinical reports and 8 months in autopsy studies). Observed survival rates were higher for patients with primary ovarian cancer (18 months), and endometrium (9 months). Median survival rate was 8 months in case of primary colon cancer. Chemotherapy and surgery allowed acceptable survival and quality of life in 8 patients with umbilical metastasis from colon cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Clinical experience suggests that an aggressive approach may offer to selected groups of patients with umbilical metastasis from abdominal cancer acceptable quality of life and improved survival probabilities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2024.110132","type":"journal-article","created":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T12:02:10Z","timestamp":1723291330000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["Sister Mary Jospeh's nodule as metastasis of colorectal cancer. Systematic review of the literature and meta-analysis"],"prefix":"10.1097","volume":"123","author":[{"given":"Raimondo","family":"Gabriele","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Campagnol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Borrelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Immacolata","family":"Iannone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Sapienza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio V.","family":"Sterpetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-7-20260507","first-page":"327","article-title":"Metastasis in Cancer. Proceedings of the Staff Meeting of the Mayo Clinic","volume":"3","author":"Mayo,","year":"1928"},{"key":"R2-7-20260507","first-page":"512","article-title":"Historical profiles of Mayo. 100th anniversary of Sister Mary Joseph Dempsey","volume":"67","author":"Nelson,","year":"1992","journal-title":"Mayo Clin. Proc."},{"issue":"12","key":"R4-7-20260507","doi-asserted-by":"crossref","first-page":"3253","DOI":"10.3390\/jcm11123253","article-title":"Vanishing bile duct syndrome in an adult patient: case report and review of the literature part 1","volume":"11","author":"Izzo,","year":"2022","journal-title":"J. Clin. Med."},{"issue":"1","key":"R5-7-20260507","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1477-7819-3-13","article-title":"Umbilical metastases: current viewpoint","volume":"3","author":"Gabriele,","year":"2005","journal-title":"World J. Surg. Oncol."},{"issue":"5","key":"R6-7-20260507","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1097\/JS9.0000000000000373","article-title":"The SCARE 2023 guideline: updating consensus Surgical CAse REport (SCARE) guidelines","volume":"109","author":"Sohrabi,","year":"2023","journal-title":"Int. J. Surg. Lond. Engl."},{"issue":"4","key":"R7-7-20260507","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.anndiagpath.2010.12.004","article-title":"Metastatic vs primary malignant neoplasms affecting the umbilicus: clinicopathologic features of 77 tumors","volume":"15","author":"Papalas,","year":"2011","journal-title":"Ann. Diagn. Pathol."},{"issue":"6","key":"R8-7-20260507","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1002\/ijc.33684","article-title":"Umbilical metastases: real-world data shows abysmal outcome","volume":"149","author":"Hugen,","year":"2021","journal-title":"Int. J. Cancer"},{"issue":"2","key":"R9-7-20260507","doi-asserted-by":"crossref","first-page":"239","DOI":"10.5732\/cjc.009.10106","article-title":"Carcinoma of the right side colon accompanied by Sister Mary Joseph's nodule and inguinal nodal metastases: a case report and literature review","volume":"29","author":"Wu,","year":"2010","journal-title":"Chin. J. Cancer"},{"issue":"4","key":"R10-7-20260507","first-page":"319","article-title":"Sister Mary Joseph's nodule: ascending colon cancer with umbilical metastasis","volume":"2","author":"Chen,","year":"2015","journal-title":"J. Cancer Res. Pract."},{"issue":"7-8","key":"R11-7-20260507","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1111\/ans.15590","article-title":"Sister Mary Joseph's nodule and colorectal cancer: an aggressive treatment for an aggressive disease","volume":"90","author":"Grossi,","year":"2020","journal-title":"ANZ J. Surg."},{"issue":"2","key":"R12-7-20260507","first-page":"325","article-title":"A long-term survival case of Sister Mary Joseph's nodule caused by colon cancer and treated with a multidisciplinary approach","volume":"81","author":"Iwata,","year":"2019","journal-title":"Nagoya J. Med. Sci."},{"key":"R13-7-20260507","doi-asserted-by":"crossref","first-page":"161","DOI":"10.11604\/pamj.2021.40.161.28407","article-title":"Radical treatment of Sister Mary-Joseph nodule: case report and literature review","volume":"40","author":"Majdoubi,","year":"2021","journal-title":"Pan Afr. Med. J."},{"issue":"2","key":"R14-7-20260507","first-page":"258","article-title":"Colonic mucinous adenocarcinoma in a pregnant woman presented as pseudo-Sister Mary Joseph's nodule: a case report","volume":"77","author":"Tarik,","year":"2022","journal-title":"Med J Malaysia"},{"issue":"13","key":"R15-7-20260507","first-page":"1828","article-title":"A case of cecal cancer diagnosed from Sister Mary Joseph's nodule","volume":"50","author":"Miyazaki,","year":"2023","journal-title":"Gan To Kagaku Ryoho"},{"issue":"2","key":"R16-7-20260507","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1177\/030089160509100221","article-title":"Metastatic tumors of the umbilicus: report of two cases and review of the literature","volume":"91","author":"Coco,","year":"2005","journal-title":"Tumori"},{"issue":"11","key":"R17-7-20260507","doi-asserted-by":"crossref","first-page":"E248","DOI":"10.1177\/000313481107701116","article-title":"Umbilical node as first clinical appearance in a patient with a high tumor burden","volume":"77","author":"Iacovelli,","year":"2011","journal-title":"Am. Surg."},{"issue":"10","key":"R18-7-20260507","first-page":"1457","article-title":"A case of Sister Mary Joseph's nodule from transverse colon cancer effectively treated with SOX plus bevacizumab chemotherapy","volume":"45","author":"Nobori,","year":"2018","journal-title":"Gan To Kagaku Ryoho"},{"issue":"3","key":"R19-7-20260507","doi-asserted-by":"crossref","first-page":"102415","DOI":"10.1016\/j.cpcardiol.2024.102415","article-title":"The role of education and information to prevent trends towards increase of cardiovascular mortality rates in Europe from 2015 TO 2019","volume":"49","author":"Sterpetti,","year":"2024","journal-title":"Curr. Probl. Cardiol."},{"key":"R20-7-20260507","doi-asserted-by":"crossref","DOI":"10.1002\/ijc.34907","article-title":"Reduced adherence to cervical cancer screening. The importance of information and education for women with low education and low-income","author":"Sterpetti,","year":"2024","journal-title":"Int. J. Cancer"},{"key":"R21-7-20260507","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.suronc.2019.12.004","article-title":"National statistics about resection of the primary tumor in asymptomatic patients with Stage IV colorectal cancer and unresectable metastases. Need for improvement in data collection. A systematic review with meta-analysis","volume":"33","author":"Sterpetti,","year":"2020","journal-title":"Surg. Oncol."},{"issue":"1","key":"R22-7-20260507","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1006\/jsre.1998.5514","article-title":"Thrombin induces production of growth factors from aortic smooth muscle cells","volume":"82","author":"Cucina,","year":"1999","journal-title":"J. Surg. Res."},{"issue":"2","key":"R23-7-20260507","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1006\/jsre.2001.6231","article-title":"Bimodal concentration-dependent effect of thrombin on endothelial cell proliferation and growth factor release in culture","volume":"100","author":"Borrelli,","year":"2001","journal-title":"J. Surg. Res."},{"key":"R24-7-20260507","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s10350-003-0018-5","article-title":"Sister Mary Joseph's nodule as a first sign of cancer of the cecum: report of a case","volume":"47","author":"Gabriele,","year":"2004","journal-title":"Dis. Colon Rectum"},{"issue":"12","key":"R25-7-20260507","doi-asserted-by":"crossref","first-page":"3253","DOI":"10.3390\/jcm11123253","article-title":"Part 2 vanishing bile duct syndrome in an adult patient: case report and review of the literature part 2","volume":"11","author":"Izzo,","year":"2022","journal-title":"J. Clin. Med."}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261224009131?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261224009131?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2024.110132","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T21:00:15Z","timestamp":1778187615000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2024.110132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":24,"journal-issue":{"issue":"C","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2024.110132","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"2024-07-31","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-07","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}