{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:46:41Z","timestamp":1793299601378,"version":"4.5.0"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T00:00:00Z","timestamp":1726099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Aortic dissection, a serious medical condition characterized by a tear in the aorta's inner layer leading to the establishment of a false channel within the vessel wall, in this report, we present a very rare case of asymptomatic substantial aortic dissection spanning from the ascending aorta to the abdominal aorta.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation:<\/jats:title>\n                    <jats:p>A 36-year-old male with fever and cough was found to have clinical features suggestive of Marfan syndrome. Examination revealed bilateral fine crackles and a diastolic heart murmur. Imaging showed bilateral infiltrates, hyperinflation, and aortic dissection. Echocardiography confirmed severe aortic valve regurgitation and Stanford type A dissection. Despite recommended surgery, the patient opted for medical therapy due to financial constraints, showing stable cardiac anomalies after 6 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>Aortic dissection, a critical cardiovascular emergency, affects mainly the elderly, exacerbated by hypertension, atherosclerosis, and connective tissue disorders. Early detection via CT and biomarkers is crucial. Type A dissections typically require surgical repair, while endovascular repair is used for complex Type B cases, reducing long-term mortality. The TEM system aids in categorization, guiding treatment. Conditions like Marfan syndrome significantly contribute to aortic wall degeneration, requiring close monitoring and intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The coalescence of aortic dissections with Marfan syndrome underscores the need for tailored monitoring in high-risk populations and highlights the silent complexities of cardiovascular pathologies, urging refined diagnostics and therapeutic approaches.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2024.110292","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T03:53:25Z","timestamp":1726718005000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Asymptomatic large aortic dissection from ascending to abdominal aorta in a young man with Marfan syndrome: A case report challenging conventional diagnostic paradigms."],"prefix":"10.1097","volume":"123","author":[{"given":"Mohammad","family":"Makhloof","sequence":"first","affiliation":[{"name":"Department of Cardiology, Almaza Military Hospital, Damascus, Syria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Alkheder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdaljawad","family":"Mazloum","sequence":"additional","affiliation":[{"name":"Department of Radiology, Al Mouwasat University Hospital, Damascus, Syria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tareq","family":"Muhammad","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Tishreen Military Hospital, Damascus, Syria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Alshara","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tishreen Military Hospital, Damascus, Syria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Firas","family":"Baddour","sequence":"additional","affiliation":[{"name":"Department of Radiology, Tishreen Military Hospital, Damascus, Syria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"5-6","key":"R1-115-20260507","first-page":"290","article-title":"La dissection aortique [aortic dissection]","volume":"73","author":"Tchana-Sato,","year":"2018","journal-title":"Rev Med Liege"},{"key":"R2-115-20260507","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/978-3-030-80614-9_8","article-title":"Pathophysiology and pathogenesis of Marfan syndrome","volume":"1348","author":"Zeigler,","year":"2021","journal-title":"Adv. Exp. Med. Biol."},{"issue":"5","key":"R3-115-20260507","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1097\/JS9.0000000000000373","article-title":"The SCARE 2023 guideline: updating consensus surgical case report (SCARE) guidelines","volume":"109","author":"Sohrabi,","year":"2023","journal-title":"Int. J. Surg. Lond. Engl."},{"issue":"4","key":"R4-115-20260507","doi-asserted-by":"crossref","DOI":"10.2174\/1573403X16666201014142930","article-title":"Aortic dissection: a review of the pathophysiology, management and prospective advances","volume":"17","author":"Sayed,","year":"2021","journal-title":"Curr. Cardiol. Rev."},{"issue":"3","key":"R5-115-20260507","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1093\/icvts\/ivz281","article-title":"Aortic dissection reconsidered: type, entry site, malperfusion classification adding clarity and enabling outcome prediction","volume":"30","author":"Sievers,","year":"2020","journal-title":"Interact. Cardiovasc. Thorac. Surg."},{"issue":"17","key":"R6-115-20260507","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1161\/CIRCULATIONAHA.117.031264","article-title":"Insights from the international registry of acute aortic dissection: a 20-year experience of collaborative clinical research","volume":"137","author":"Evangelista,","year":"2018","journal-title":"Circulation"},{"issue":"2","key":"R7-115-20260507","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/nrcardio.2010.187","article-title":"Epidemiology of thoracic aortic dissection","volume":"8","author":"LeMaire,","year":"2011","journal-title":"Nat. Rev. Cardiol."},{"issue":"6","key":"R8-115-20260507","doi-asserted-by":"crossref","first-page":"582","DOI":"10.21037\/acs.2017.11.03","article-title":"Differences in manifestations of Marfan syndrome, Ehlers-Danlos syndrome, and Loeys-Dietz syndrome","volume":"6","author":"Meester,","year":"2017","journal-title":"Ann. Cardiothorac. 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