{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:07:38Z","timestamp":1786118858274,"version":"build-2736575974"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T00:00:00Z","timestamp":1726099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Throughout the literature, many cases of vascular Ehlers-Danlos were reported with a variation of its clinical presentation. This disease may present in many forms and aspects and some even die before seeking medical care and getting the right diagnosis due to its hard effect on patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation:<\/jats:title>\n                    <jats:p>We report a case of a 25-year-old female patient with a history of multiple bowel perforations that were operated on urgently numerous times and received many courses of a large spectrum of antibiotics for various infections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical discussion:<\/jats:title>\n                    <jats:p>Further investigations showed that the patient had multiple aneurysms due to her disease, a hepatic aneurysm, a paraspinal, and a severally symptomatic wrist aneurysm. The patient presented a de novo variant in the COL3A1 gene. A management plan was personalized, and a family genetic investigation was carried out.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This article contains a full history of this patient including all the surgical, medical, and radiological interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2024.110294","type":"journal-article","created":{"date-parts":[[2024,9,14]],"date-time":"2024-09-14T12:31:42Z","timestamp":1726317102000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Surviving the storm: A 6-year journey with bowel perforations and aneurysms in vascular Ehlers-Danlos syndrome \u2014 A case report"],"prefix":"10.1097","volume":"124","author":[{"given":"Farid Abi","family":"Habib","sequence":"first","affiliation":[{"name":"Department of Digestive Surgery, Hotel Dieu de France Hospital, Saint Joseph University - Faculty of Medicine, Beirut, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Osseis","sequence":"additional","affiliation":[{"name":"Department of Digestive Surgery, Hotel Dieu de France Hospital, Saint Joseph University - Faculty of Medicine, Beirut, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Chebly","sequence":"additional","affiliation":[{"name":"Center Jacques Loiselet for Medical Genetics and Genomics (CGGM), Faculty of Medicine, Saint Joseph University, Beirut, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elie","family":"El Feghali","sequence":"additional","affiliation":[{"name":"Department of Digestive Surgery, Hotel Dieu de France Hospital, Saint Joseph University - Faculty of Medicine, Beirut, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Noun","sequence":"additional","affiliation":[{"name":"Department of Digestive Surgery, Hotel Dieu de France Hospital, Saint Joseph University - Faculty of Medicine, Beirut, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-8-20260421","doi-asserted-by":"crossref","first-page":"1246712","DOI":"10.3389\/fgene.2023.1246712","article-title":"Importance of comprehensive genetic testing for patients with suspected vascular Ehlers-Danlos syndrome: a family case report and literature review","volume":"14","author":"Wei,","year":"2023","journal-title":"Front. Genet."},{"issue":"5","key":"R3-8-20260421","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1097\/JS9.0000000000000373","article-title":"The SCARE 2023 guideline: updating consensus Surgical Case Report (SCARE) guidelines","volume":"109","author":"Sohrabi,","year":"2023","journal-title":"Int. J. Surg."},{"issue":"5","key":"R4-8-20260421","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology","volume":"17","author":"Richards,","year":"2015","journal-title":"Genet. Med."},{"issue":"8","key":"R5-8-20260421","article-title":"Bowel perforation in vascular Ehlers-Danlos syndrome","volume":"13","author":"Menni,","year":"2023","journal-title":"Case Report and Comprehensive Review. J Pers Med."},{"issue":"5","key":"R6-8-20260421","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1089\/sur.2022.403","article-title":"Letter to the editor: spontaneous colon perforation in Ehlers-Danlos syndrome type IV caused by a novel, spontaneous, De novo mutation of COL3A1","volume":"24","author":"Barie,","year":"2023","journal-title":"Surg. Infect. (Larchmt.)"},{"issue":"4","key":"R7-8-20260421","doi-asserted-by":"crossref","DOI":"10.1093\/jscr\/rjac192","article-title":"Spontaneous small bowel perforation: a rare GI manifestation of type IV Ehlers-Danlos syndrome","volume":"2022","author":"Gallagher,","year":"2022","journal-title":"J Surg Case Rep."},{"issue":"1","key":"R8-8-20260421","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s40792-024-01845-6","article-title":"Successful management of splenic artery dissection after sigmoid colon perforation in vascular Ehlers-Danlos syndrome","volume":"10","author":"Yoshizaki,","year":"2024","journal-title":"Surg Case Rep."},{"issue":"2","key":"R9-8-20260421","article-title":"Endovascular intervention to treat spontaneous carotid-cavernous fistula in a patient with Ehlers-Danlos syndrome with an access site anatomical variant","volume":"10","author":"See,","year":"2024","journal-title":"BJR Case Rep."},{"issue":"2","key":"R10-8-20260421","first-page":"123","article-title":"A contemporary review of the diagnosis and management of vascular Ehlers-Danlos syndrome","volume":"15","author":"Chen,","year":"2024","journal-title":"Journal of Vascular Medicine."},{"issue":"2","key":"R11-8-20260421","doi-asserted-by":"crossref","first-page":"482","DOI":"10.2214\/AJR.11.6603","article-title":"Vascular complications of Ehlers-Danlos syndrome: CT findings","volume":"198","author":"Chu,","year":"2012","journal-title":"AJR Am. J. Roentgenol."},{"issue":"1","key":"R12-8-20260421","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jvs.2009.08.019","article-title":"Contemporary management of vascular complications associated with Ehlers-Danlos syndrome","volume":"51","author":"Brooke,","year":"2010","journal-title":"J. Vasc. Surg."}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261224010757?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261224010757?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ovid.com\/10.1016\/j.ijscr.2024.110294","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T16:56:20Z","timestamp":1786035380000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.1016\/j.ijscr.2024.110294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":11,"journal-issue":{"issue":"C","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2024.110294","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"2024-07-16","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-11","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}