{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:06:11Z","timestamp":1786118771661,"version":"build-2736575974"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T00:00:00Z","timestamp":1726876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>The location in the neck of small cell neuroendocrine carcinoma (SCNEC) is rare and aggressive with a poor prognosis.<\/jats:p>\n                    <jats:p>We herein describe an extremely uncommon example of cervical SCNEC probably arising in the parotid gland, diagnosed at an advanced metastatic stage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Presentation of case:<\/jats:title>\n                    <jats:p>A 76 year old man, non-smoking, non-alcoholic presented a left cervical and rapidly progressive mass. It was suspicious of malignancy and located in the parotid space and II, III, IV and V lymph node groups. In two weeks, the patient had presented a rapid increase in size, with extensive skin permeation. CT scan revealed a large mass infiltrating the left parotid and submandibular glands compressing the jugulo-carotid vascular axis and liver metastases. Diagnosis was made on the morphological pathological examination supplemented by the immunohistochemistry examination, indeed, cells were immunoreactive for chromogranin A as well as synaptophysin. Chemotherapy based on cisplatin and Etoposide VP 16 was started but the evolution was unfavorable: death occurred after 2 cycles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical discussion:<\/jats:title>\n                    <jats:p>Neuroendocrine neoplasm arises from neural crest cells. Its location in the head and neck is extremely rare with a tendency for aggressive local invasion and a strong propensity for both regional and distant metastasis. Treatment may include surgical resection, radiotherapy, chemotherapy, or combination of these modalities. The prognosis is poor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The clinician must discuss the diagnosis of cervical SCNEC when faced with a man in the seventh decade who presents an agressive rapidly expanding cervical mass. The diagnosis confirmation is pathological combining morphological and immunohistochemical evaluations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2024.110341","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T19:49:06Z","timestamp":1727207346000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Agressive small cell neuroendocrine carcinoma of the neck: A case report"],"prefix":"10.1097","volume":"124","author":[{"given":"G.","family":"Kharrat","sequence":"first","affiliation":[{"name":"ENT department, Mohamed Taher Ma\u00e2mouri University Hospital of Nabeul, Faculty of Medicine, El Manar University of Tunis, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Ferchichi","sequence":"additional","affiliation":[{"name":"ENT department, Mohamed Taher Ma\u00e2mouri University Hospital of Nabeul, Faculty of Medicine, El Manar University of Tunis, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Azaiez","sequence":"additional","affiliation":[{"name":"ENT department, Mohamed Taher Ma\u00e2mouri University Hospital of Nabeul, Faculty of Medicine, El Manar University of Tunis, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ferjani","sequence":"additional","affiliation":[{"name":"ENT department, Mohamed Taher Ma\u00e2mouri University Hospital of Nabeul, Faculty of Medicine, El Manar University of Tunis, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Chalbi","sequence":"additional","affiliation":[{"name":"Pathology department, Mohamed Taher Ma\u00e2mouri University Hospital of Nabeul, Faculty of Medicine, El Manar University of Tunis, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Marrakchi","sequence":"additional","affiliation":[{"name":"Regional hospital of Menzel Bourguiba, Faculty of Medicine, El Manar University of Tunis, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-30-20260421","article-title":"Small cell neuro- endocrine of the head and neck: a rare presentation and review of the literature","volume":"10","author":"Niforatos,","year":"2022","journal-title":"Investig Med High Impact Case Rep."},{"issue":"4","key":"R2-30-20260421","doi-asserted-by":"crossref","DOI":"10.1016\/j.amjoto.2021.102992","article-title":"Neuroendocrine carcinomas of the head and neck: a small case series","volume":"42","author":"Mitchell,","year":"2021","journal-title":"Am. 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