{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:29:19Z","timestamp":1790285359896,"version":"4.1.0"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T00:00:00Z","timestamp":1727222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004031","name":"Jichi Medical University","doi-asserted-by":"publisher","award":["JP23K08968"],"award-info":[{"award-number":["JP23K08968"]}],"id":[{"id":"10.13039\/501100004031","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP23K08968"],"award-info":[{"award-number":["JP23K08968"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Moderately differentiated neuroendocrine tumors of the larynx are rare malignant tumors that arise from the submucosa of the larynx, for which surgery is the first-line treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Presentation of case:<\/jats:title>\n                    <jats:p>We report a case of moderately differentiated neuroendocrine tumor of the larynx, in which the patient, a 74-year-old man, experienced long-term palliation but an unfortunate outcome of death owing to metastasis. Laryngeal endoscopic examination revealed an elevated submucosal lesion on the laryngeal surface of the epiglottis. Computed tomography and magnetic resonance imaging showed a tumor-like lesion demonstrating a contrasting effect in the submucosa of the epiglottis. A biopsy revealed a moderately differentiated neuroendocrine tumor (formerly called an atypical carcinoid), and a horizontal partial laryngectomy was performed. The patient had a good postoperative course; however, three years and ten months after surgery, he experienced recurrence in the upper gastrointestinal tract and carcinoid syndrome and died four years and three months after the surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>The prognosis of laryngeal neuroendocrine tumors remains poor. In this case, local control was possible without irradiation because the resection margins were negative on pathological examination. This case report has been reported in line with the SCARE Criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Long-term follow-up of this type of tumor is necessary, as distant metastasis is likely to affect prognosis. In addition to surgery, effective adjuvant therapies, including molecular targeted therapies, should be established.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2024.110356","type":"journal-article","created":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T20:56:39Z","timestamp":1727384199000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Horizontal partial laryngectomy for laryngeal neuroendocrine tumor: A case report"],"prefix":"10.1097","volume":"124","author":[{"given":"Kazutaka","family":"Kashima","sequence":"first","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Jichi Medical University, School of Medicine, Shimotsuke 329-0498, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Igarashi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Jichi Medical University, School of Medicine, Shimotsuke 329-0498, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Radiology, Jichi Medical University, School of Medicine, Shimotsuke 329-0498, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyoshi","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Department of Pathology, Jichi Medical University, School of Medicine, Shimotsuke 329-0498, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Nishino","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Jichi Medical University, School of Medicine, Shimotsuke 329-0498, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeharu","family":"Kanazawa","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Jichi Medical University, School of Medicine, Shimotsuke 329-0498, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"2","key":"R1-41-20260421","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1177\/0145561320943340","article-title":"A rare case of primary neuroendocrine carcinomas in the ear and throat and review of literatures","volume":"101","author":"Ma,","year":"2022","journal-title":"Ear Nose Throat J."},{"issue":"4","key":"R2-41-20260421","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1002\/hed.20797","article-title":"Primary and secondary small cell neuroendocrine carcinoma of the larynx: a review","volume":"30","author":"Ferlito,","year":"2008","journal-title":"Head Neck"},{"issue":"4","key":"R3-41-20260421","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1159\/000276218","article-title":"Carcinoid tumor of the larynx. A critical review of the literature","volume":"53","author":"El-Naggar,","year":"1991","journal-title":"ORL J. Otorhinolaryngol. Relat. Spec."},{"issue":"12","key":"R4-41-20260421","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.neo.2017.09.002","article-title":"Nothing but NET: a review of neuroendocrine tumors and carcinomas","volume":"19","author":"Oronsky,","year":"2017","journal-title":"Neoplasia"},{"issue":"5","key":"R5-41-20260421","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1097\/JS9.0000000000000373","article-title":"The SCARE 2023 guideline: updating consensus Surgical CAse REport (SCARE) guidelines","volume":"109","author":"Sohrabi,","year":"2023","journal-title":"Int J Surg Lond Engl."},{"issue":"1","key":"R6-41-20260421","first-page":"5","article-title":"Laryngeal endocrinomas (carcinoids and relevant neoplasms): analysis of 278 reported cases","volume":"21","author":"Soga,","year":"2002","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"12","key":"R7-41-20260421","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1002\/hed.21162","article-title":"Neuroendocrine neoplasms of the larynx: an overview","volume":"31","author":"Ferlito,","year":"2009","journal-title":"Head Neck"},{"issue":"6","key":"R8-41-20260421","article-title":"Neuroendocrine neoplasms of the head and neck: a case report on an oropharyngeal presentation","volume":"15","author":"Maeso Riera,","year":"2023","journal-title":"Cureus"},{"key":"R9-41-20260421","doi-asserted-by":"crossref","first-page":"21","DOI":"10.21037\/acr-23-70","article-title":"Calcitonin-secreting neuroendocrine tumor of the larynx, a diagnostic challenge of a rare neoplasm: a case report and literature review","volume":"8","author":"Filippini,","year":"2024","journal-title":"AME Case Rep"},{"issue":"2","key":"R10-41-20260421","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s12105-021-01367-9","article-title":"Neuroendocrine neoplasms of the larynx: a clinicopathologic analysis of 27 neuroendocrine tumors and neuroendocrine carcinomas","volume":"16","author":"Bal,","year":"2022","journal-title":"Head Neck Pathol."},{"issue":"1","key":"R11-41-20260421","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.anl.2010.05.008","article-title":"Atypical carcinoid of the larynx and expressions of proteins associated with molecular targeted therapy","volume":"38","author":"Kanazawa,","year":"2011","journal-title":"Auris Nasus Larynx"},{"issue":"5","key":"R12-41-20260421","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1002\/hed.23666","article-title":"Clinical recommendations on the treatment of neuroendocrine carcinoma of the larynx: a meta-analysis of 436 reported cases","volume":"37","author":"van der Laan,","year":"2015","journal-title":"Head Neck"},{"issue":"7","key":"R14-41-20260421","first-page":"607","article-title":"Diagnosis, treatment and clinical analysis of 25 cases of laryngeal neuroendocrine carcinoma","volume":"32","author":"Zhang,","year":"2019","journal-title":"J Cancer Control Treat."},{"issue":"4","key":"R15-41-20260421","first-page":"517","article-title":"Carcinoids and their variant endocrinomas. 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