{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T15:06:49Z","timestamp":1776784009387,"version":"3.51.2"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T00:00:00Z","timestamp":1727827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Ewing sarcoma is an aggressive tumor characterized by small round cells and diffuse CD99 positivity seen mainly in Caucasian childhood and adolescent demographics. Ewing sarcoma of spinal origin accounts for approximately 3-9 % of cases most of these cases affecting the sacrum, therefore lumbar lesions are considered quite rare.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case report:<\/jats:title>\n                    <jats:p>We report a case of lumbar Ewing sarcoma in a 6-year-old female who presented with back pain and neurological symptoms of spinal compression such as lower limb weakness, constipation, and urinary retention. MRI imaging confirmed the presence of a mass located at the level of L4 and L5 vertebrates causing spinal cord compression, The patient underwent local resection of the tumor, and a biopsy was sent for histology and immunophenotyping which affirmed the diagnosis of Ewing sarcoma. The patient was referred to an oncology center for follow-up chemotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical discussion:<\/jats:title>\n                    <jats:p>Ewing sarcoma is the second most common tumor of childhood and adolescence. However, a tumor arising from the spine is considered rare. It presents with localized symptoms of pain and fever but may cause neural compression symptoms.<\/jats:p>\n                    <jats:p>Accurate diagnosis relies mainly on radiological scans, histology, and immunohistochemical analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Although Ewing sarcoma of the lumbar spine is rare, it should always be considered among pediatric populations developing localized fever and pain. Early detection is crucial to avoid undesired outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2024.110412","type":"journal-article","created":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T11:55:08Z","timestamp":1727956508000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Lumbar spine Ewing sarcoma: A report of a rare localization"],"prefix":"10.1097","volume":"124","author":[{"given":"Zyad","family":"Al-Frejat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alia","family":"Esper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-93-20260421","article-title":"Middle East Journal of Cancer","volume":"6","author":"Nair,","year":"2015","journal-title":"Middle East Journal of Cancer"},{"key":"R2-93-20260421","article-title":"Ewing's sarcoma of the vertebral body in an adolescent: a rare case report and literature review","volume":"13","author":"Goh,","year":"2021","journal-title":"Cureus"},{"key":"R3-93-20260421","first-page":"8027137","article-title":"Primary Ewing's sarcoma of the spine in a two-year-old boy","volume":"2016","author":"Electricwala,","year":"2016","journal-title":"Case Rep. Orthop."},{"key":"R4-93-20260421","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2006.12.009","article-title":"The biology of Ewing sarcoma","volume":"254","author":"Riggi,","year":"2007","journal-title":"Cancer Lett."},{"key":"R5-93-20260421","article-title":"Ewing's sarcoma of the vertebral body in an adolescent: a rare case report and literature review","volume":"13","author":"Goh,","year":"2021","journal-title":"Cureus"},{"key":"R6-93-20260421","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1097\/JS9.0000000000000373","article-title":"The SCARE 2023 guideline: updating consensus Surgical CAse REport (SCARE) guidelines","volume":"109","author":"Sohrabi,","year":"2023","journal-title":"Int. J. Surg."},{"key":"R7-93-20260421","article-title":"Primary Ewing's sarcoma of the spine: about a case","volume":"9","author":"Cherraqi,","year":"2022","journal-title":"Glob Pediatr Health"},{"key":"R8-93-20260421","doi-asserted-by":"crossref","first-page":"142","DOI":"10.4103\/0973-1482.95197","article-title":"Rare case of extraskeletal Ewings sarcoma of the sinonasal tract","volume":"8","author":"Yeshvanth,","year":"2012","journal-title":"J. Cancer Res. Ther."},{"key":"R9-93-20260421","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1097\/01.pas.0000167056.13614.62","article-title":"Morphologic and immunophenotypic diversity in Ewing family tumors: a study of 66 genetically confirmed cases","volume":"29","author":"Folpe,","year":"2005","journal-title":"Am. J. Surg. Pathol."},{"key":"R10-93-20260421","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1590\/S0004-282X2006000400026","article-title":"Primary Ewing's sarcoma of the spine: case report","volume":"64","author":"Dini,","year":"2006","journal-title":"Arq. Neuropsiquiatr."},{"key":"R11-93-20260421","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1097\/00007632-199402000-00009","article-title":"Primary Ewing's sarcoma of the spine.","volume":"19","author":"Grubb","year":"1994","journal-title":"Spine (Phila Pa 1976)"},{"key":"R12-93-20260421","first-page":"837","article-title":"Birth characteristics and risk of Ewing sarcoma","volume":"34","author":"Wiemels,","year":"2023","journal-title":"Cancer Causes Control"},{"key":"R13-93-20260421","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1590\/S1807-59322006000200003","article-title":"Comparative analysis between osteosarcoma and Ewing's sarcoma: evaluation of the time from onset of signs and symptoms until diagnosis","volume":"61","author":"Guerra,","year":"2006","journal-title":"Clinics"},{"key":"R14-93-20260421","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s41572-018-0003-x","article-title":"Ewing sarcoma","volume":"4","author":"Gr\u00fcnewald,","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"key":"R15-93-20260421","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/j.ajhg.2022.04.007","article-title":"Germline predisposition to pediatric Ewing sarcoma is characterized by inherited pathogenic variants in DNA damage repair genes","volume":"109","author":"Gillani,","year":"2022","journal-title":"Am. J. Hum. Genet."},{"key":"R17-93-20260421","first-page":"18","article-title":"Suitability of imaging methods (X-ray, CT, MRI) in the diagnostics of Ewing's sarcoma in children - analysis of own material","volume":"75","author":"Kuleta-Bosak,","year":"2010","journal-title":"Pol. J. Radiol."},{"key":"R18-93-20260421","doi-asserted-by":"crossref","first-page":"5435","DOI":"10.1200\/JCO.2007.12.2473","article-title":"Positron emission tomography for staging of pediatric sarcoma patients: results of a prospective multicenter trial","volume":"25","author":"V\u00f6lker,","year":"2007","journal-title":"J. Clin. Oncol."},{"key":"R19-93-20260421","doi-asserted-by":"crossref","first-page":"168","DOI":"10.13107\/jocr.2024.v14.i03.4330","article-title":"Philosophies and surgical techniques for Ewing's sarcoma of spine with review of literature","volume":"14","author":"Sakhrekar,","year":"2024","journal-title":"J Orthop Case Rep"},{"key":"R20-93-20260421","first-page":"1262","article-title":"Impact of first-line treatment on outcomes of Ewing sarcoma of the spine","volume":"8","author":"Zhang,","year":"2018","journal-title":"Am. J. Cancer Res."}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261224011933?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261224011933?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2024.110412","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T14:03:37Z","timestamp":1776780217000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2024.110412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":19,"journal-issue":{"issue":"C","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2024.110412","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"2024-08-29","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-02","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}