{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T21:43:09Z","timestamp":1776980589361,"version":"3.51.4"},"reference-count":7,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T00:00:00Z","timestamp":1728604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction and importance:<\/jats:title>\n                    <jats:p>Primary anorectal melanoma (ARM) is a rare neoplasm with an extremely poor prognosis. It represents less than 1 % of all melanomas and accounts for less than 1 % of anorectal malignancies. We report a case of anorectal primary melanoma treated surgically.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation:<\/jats:title>\n                    <jats:p>A 73-year-old presented with a rectal syndrome evolving over 3 months, associated with rectal bleeding and sub-occlusive syndromes progressing in the context of general deterioration. Anal margin examination showed a protruding lesion with blackish color of the anal mucosa. Biopsies with histopathological examination concluded a malignant melanoma with necrotic changes. Locoregional staging with thoracic-abdominal-pelvic CT scan revealed a suspicious thickening of the rectum's lower wall contacting the posterior wall of the vagina, with loss of fat stranding associated with multiple mesorectal lymph nodes without distant secondary lesions. A laparoscopic proctectomy was performed.<\/jats:p>\n                    <jats:p>A histopathological examination of the specimen confirmed the diagnosis with clean margins. The patient recovered uneventfully.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>Anorectal melanoma is an exceedingly rare form of cancer, comprising less than 1 % of all anorectal malignancies.<\/jats:p>\n                    <jats:p>Surgical intervention remains the primary treatment modality for anorectal melanoma. Abdominoperineal resection has traditionally been the mainstay approach.<\/jats:p>\n                    <jats:p>Studies have suggested that localized excision coupled with adjuvant therapies such as low-dose radiotherapy may offer comparable local control rates to traditional abdominopelvic resection while preserving sphincter function and quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Anorectal melanoma is a rare disease with poor prognosis. The lack of high-volume data researches shows the missing guideline for this disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2024.110458","type":"journal-article","created":{"date-parts":[[2024,10,12]],"date-time":"2024-10-12T11:13:54Z","timestamp":1728731634000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Anorectal melanoma: A case report of an unusual localization"],"prefix":"10.1097","volume":"125","author":[{"given":"Atri","family":"Souhaib","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ouadi","family":"Yacine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hammami","family":"Mahdi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebei","family":"Amine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haddad","family":"Anis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Montasser","family":"Kacem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"issue":"8","key":"R1-10-20260423","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1002\/(SICI)1097-0142(19990415)85:8<1686::AID-CNCR7>3.0.CO;2-7","article-title":"Malignant tumors of the anal canal: the spectrum of disease, treatment, and outcomes","volume":"85","author":"Klas,","year":"1999","journal-title":"Cancer"},{"issue":"9","key":"R2-10-20260423","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1002\/bjs.4592","article-title":"Surgical management of primary anorectal melanoma","volume":"91","author":"Pessaux,","year":"2004","journal-title":"Br. J. Surg."},{"issue":"5","key":"R3-10-20260423","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1097\/JS9.0000000000000373","article-title":"The SCARE 2023 guideline: updating consensus Surgical CAse REport (SCARE) guidelines","volume":"109","author":"Sohrabi,","year":"2023","journal-title":"Int. J. Surg."},{"issue":"6","key":"R4-10-20260423","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1001\/jamasurg.2013.4643","article-title":"Clinicopathologic presentation and natural history of anorectal melanoma: a case series of 18 patients","volume":"149","author":"Hicks,","year":"2014","journal-title":"JAMA Surg."},{"issue":"4","key":"R5-10-20260423","doi-asserted-by":"crossref","DOI":"10.2144\/fsoa-2021-0091","article-title":"Clinicopathological profile and outcomes of anorectal melanoma from a tertiary care center in India","volume":"8","author":"Garg,","year":"2022","journal-title":"Future Sci. OA"},{"issue":"1","key":"R6-10-20260423","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.pathol.2018.09.060","article-title":"Primary anorectal melanoma: clinical, immunohistology and DNA analysis of 43 cases","volume":"51","author":"Dodds,","year":"2019","journal-title":"Pathology"},{"issue":"1","key":"R7-10-20260423","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s12032-014-0445-2","article-title":"Anorectal malignant melanoma: retrospective analysis of management and outcome in a single Portuguese Institution","volume":"32","author":"Miguel,","year":"2015","journal-title":"Med. Oncol."}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261224012392?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261224012392?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2024.110458","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T21:04:06Z","timestamp":1776978246000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2024.110458"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":7,"journal-issue":{"issue":"C","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2024.110458","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"2024-09-30","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-11","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}