{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:08:18Z","timestamp":1786118898537,"version":"build-2736575974"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T00:00:00Z","timestamp":1731024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction and importance:<\/jats:title>\n                    <jats:p>The curative options for locally advanced hepatocellular carcinomas involving the vessels are very limited. Ex vivo liver resection and auto transplantation (ERAT) is a novel surgical method, which has been used in the management of such complex liver space occupying lesions, which are rendered conventionally unresectable. This technique involves a complete hepatectomy, extracorporeal hepatic resection on the backbench, and then reimplantation of the remnant hepatic parenchyma. George et al. (2019) [1] In literature, Ex vivo liver resection and auto transplantation (ERAT) has been utilized in the management of both benign and malignant liver lesions, including hepatocellular carcinoma (HCC), cholangiocarcinoma, hepatic metastases, hepatic alveolar echinococcosis, focal nodular hyperplasia and hemangioma. Zawistowski et al. (2020) [2].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation:<\/jats:title>\n                    <jats:p>We report this case of a 28 years old male with a giant hepatocellular carcinoma, that deemed unresectable as it was closely abutting all three hepatic veins. After appropriate preoperative surgical planning, he underwent ex vivo liver resection and autotransplantation (ERAT). Patient had gradual uneventful recovery and he was discharged home on 12th postoperative day.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical discussion:<\/jats:title>\n                    <jats:p>A radical (R0) resection is the main goal of the ex vivo liver resection and autotransplantation (ERAT) procedure, which can be used for curative intent in patients with liver lesions that are conventionally inoperable. It allows for precise extracorporeal resection, maximizes the residual liver volume and increases the likelihood of obtaining negative margins. Furthermore, the bench surgery in ice bath makes it easier to reconstruct the vasculature without the pressure of time constraints in situ, unlike conventional surgery, which can take a long time when done in a bleeding operative field. Zawistowski et al. (2020) [2].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>For patients with complex liver lesions believed to be incurable with conventional surgical methods, ex vivo liver resection and autotransplantation (ERAT) provides an alternative.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2024.110573","type":"journal-article","created":{"date-parts":[[2024,11,9]],"date-time":"2024-11-09T13:51:07Z","timestamp":1731160267000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["EX vivo liver resection and auto transplantation for a giant hepatocellular carcinoma: A case report"],"prefix":"10.1097","volume":"125","author":[{"given":"Noureen","family":"Kanwal","sequence":"first","affiliation":[{"name":"Liver transplant and HPB Surgery Unit, Dow University Hospital, DUHS, Karachi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jahanzaib","family":"Haider","sequence":"additional","affiliation":[{"name":"Liver transplant and HPB Surgery Unit, Dow University Hospital, DUHS, Karachi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siraj","family":"Haider","sequence":"additional","affiliation":[{"name":"Liver transplant and HPB Surgery Unit, Dow University Hospital, DUHS, Karachi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Iqbal","sequence":"additional","affiliation":[{"name":"Liver transplant and HPB Surgery Unit, Dow University Hospital, DUHS, Karachi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran","family":"Amir","sequence":"additional","affiliation":[{"name":"Liver transplant and HPB Surgery Unit, Dow University Hospital, DUHS, Karachi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faisal Saud","family":"Dar","sequence":"additional","affiliation":[{"name":"Pakistan Kidney and Liver Institute and Research Center, Lahore, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-94-20260423","first-page":"12","article-title":"Ex situ liver resection and autotransplantation for advanced cholangiocarcinoma","volume":"19","author":"George,","year":"2019","journal-title":"BMJ Case Rep."},{"key":"R4-94-20260423","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/5942306","article-title":"Hepatocellular carcinoma in Pakistan: National Trends and global perspective","volume":"2016","author":"Hafeez Bhatti,","year":"2016","journal-title":"Gastroenterol. Res. Pract."},{"issue":"1","key":"R5-94-20260423","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4254\/wjh.v11.i1.1","article-title":"Hepatocellular carcinoma in non-cirrhotic liver: a comprehensive review.","volume":"11","author":"Desai","year":"2019","journal-title":"World J. Hepatol."},{"issue":"2","key":"R6-94-20260423","first-page":"122","article-title":"Ex situ operation on the liver. A new possibility in liver surgery","volume":"373","author":"Pichlmayr,","year":"1988","journal-title":"Langenbecks Arch. Chir."},{"issue":"1","key":"R7-94-20260423","first-page":"1042","article-title":"Ex situ hepatectomy and liver autotransplantation for a treating giant solitary fibrous tumor: a case report","volume":"17","author":"Sun,","year":"2019","journal-title":"Oncol. Lett."},{"issue":"5","key":"R8-94-20260423","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.jhep.2018.09.005","article-title":"Ex vivo liver resection and autotransplantation: an emerging option in selected indications","volume":"69","author":"Hwang,","year":"2018","journal-title":"J. Hepatol."},{"issue":"5","key":"R9-94-20260423","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1097\/JS9.0000000000000373","article-title":"The SCARE 2023 guideline: updating consensus surgical CAse REport (SCARE) guidelines","volume":"109","author":"Sohrabi,","year":"2023","journal-title":"Int J Surg Lond Engl."},{"issue":"2","key":"R10-94-20260423","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1111\/ajt.13465","article-title":"Ex vivo liver resection and autotransplantation for end-stage alveolar echinococcosis: a case series","volume":"16","author":"Wen,","year":"2016","journal-title":"Am. J. Transplant."},{"issue":"1","key":"R11-94-20260423","doi-asserted-by":"crossref","first-page":"97","DOI":"10.4103\/njs.NJS_4_18","article-title":"Ex situ liver resection and partial liver autotransplantation for advanced cholangiocarcinoma","volume":"25","author":"Ozsoy,","year":"2019","journal-title":"Niger J Surg."},{"issue":"4","key":"R12-94-20260423","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.21037\/apm-20-184","article-title":"Current status of ex-vivo liver resection and autologous liver transplantation for end-stage hepatic alveolar echinococcosis","volume":"9","author":"Yang,","year":"2020","journal-title":"Ann Palliat Med."}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261224013543?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261224013543?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ovid.com\/10.1016\/j.ijscr.2024.110573","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T16:59:41Z","timestamp":1786035581000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.1016\/j.ijscr.2024.110573"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":10,"journal-issue":{"issue":"C","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2024.110573","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"2024-09-27","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-08","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}