{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T13:52:27Z","timestamp":1778939547525,"version":"3.51.4"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T00:00:00Z","timestamp":1731542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014717","name":"National Outstanding Youth Science Fund Project of National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82104914"],"award-info":[{"award-number":["82104914"]}],"id":[{"id":"10.13039\/100014717","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Intramural ectopic pregnancy (IMP) refers to the implantation and implantation of a gestational sac in the uterine muscle layer, which is a rare and potentially life-threatening disease. Early detection and diagnosis are significant, and treatment methods are often challenging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Presentation of case:<\/jats:title>\n                    <jats:p>We report a case of IMP after embryo transfer in a 38-year-old woman. The patient developed persistent ectopic pregnancy after combined hysteroscopic and laparoscopic surgery. Intramuscular injection of methotrexate did not have a significant effect, and transabdominal ultrasound-guided in situ injection of methotrexate at the site of the lesion was performed with a significant impact.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>This case emphasizes the complexity of the treatment of IMP. Surgery alone may not allow complete excision of the lesion, and residual chorionic tissue may invade the muscular vessels; this case emphasizes the importance of postoperative drug therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>IMP invades the myometrium in a widely spreading manner, and methotrexate injection in situ at the site of the lesion after conservative surgery may become an efficacious treatment modality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2024.110623","type":"journal-article","created":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T23:40:29Z","timestamp":1732059629000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Persistence of ectopic pregnancy after intramural ectopic pregnancy surgery: A case report"],"prefix":"10.1097","volume":"126","author":[{"given":"Wen-Xiu","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Reproduction and Genetics, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting-Ting","family":"Wang","sequence":"additional","affiliation":[{"name":"First School of Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuai","family":"Zhao","sequence":"additional","affiliation":[{"name":"First School of Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"issue":"6","key":"R1-10-20260508","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1002\/jcu.20703","article-title":"Sonographic diagnosis and successful medical management of an intramural ectopic pregnancy","volume":"38","author":"Ong","year":"2010","journal-title":"J. Clin. Ultrasound"},{"issue":"4","key":"R2-10-20260508","article-title":"Terminology for describing normally sited and ectopic pregnancies on ultrasound: ESHRE recommendations for good practice","volume":"2020","author":"Kirk","year":"2020","journal-title":"Hum. Reprod. Open."},{"issue":"6","key":"R3-10-20260508","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1111\/jog.13322","article-title":"Ultrasound diagnosis of intramural pregnancy","volume":"43","author":"Liu","year":"2017","journal-title":"J. Obstet. Gynaecol. Res."},{"issue":"5","key":"R4-10-20260508","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1097\/JS9.0000000000000373","article-title":"The SCARE 2023 guideline: updating consensus surgical CAse REport (SCARE) guidelines","volume":"109","author":"Sohrabi","year":"2023","journal-title":"Int. J. Surg."},{"issue":"21","key":"R5-10-20260508","article-title":"Intramural ectopic pregnancy: an individual patient data systematic review","volume":"20","author":"Ntafam","year":"2023","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol. X."},{"issue":"6","key":"R6-10-20260508","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1002\/jcu.20703","article-title":"Sonographic diagnosis and successful medical management of an intramural ectopic pregnancy","volume":"38","author":"Ong","year":"2010","journal-title":"J. Clin. Ultrasound"},{"key":"R7-10-20260508","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.ejogrb.2014.02.027","article-title":"Intramural pregnancy: a case report","volume":"176","author":"Liu","year":"2014","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"issue":"1","key":"R8-10-20260508","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s12905-024-03027-w","article-title":"A rare case of fundal intramural ectopic pregnancy associated with previous B-lynch sutures","volume":"24","author":"Xiang","year":"2024","journal-title":"BMC Womens Health"},{"issue":"8","key":"R9-10-20260508","article-title":"Intramural ectopic pregnancy: clinical characteristics, risk factors for uterine rupture and hysterectomy","volume":"28","author":"Chen","year":"2021","journal-title":"Front. Med. (Lausanne)"},{"issue":"9","key":"R10-10-20260508","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.12998\/wjcc.v10.i9.2871","article-title":"Intramural pregnancy after in vitro fertilization and embryo transfer: a case report","volume":"10","author":"Xie","year":"2022","journal-title":"World J. Clin. Cases"},{"issue":"6","key":"R11-10-20260508","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.jmig.2018.10.004","article-title":"Factors predicting persistent ectopic pregnancy after laparoscopic salpingostomy or salpingotomy for tubal pregnancy: a retrospective Cohort Study","volume":"26","author":"Ting","year":"2019","journal-title":"J. Minim. Invasive Gynecol."},{"issue":"7","key":"R12-10-20260508","doi-asserted-by":"crossref","DOI":"10.1016\/j.jogoh.2022.102419","article-title":"Local injection of methotrexate ultrasound guided-transvaginal","volume":"51","author":"Allegrini","year":"2022","journal-title":"J. Gynecol. Obstet. Hum. 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