{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T22:11:39Z","timestamp":1778278299195,"version":"3.51.4"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T00:00:00Z","timestamp":1732665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>A Giant Cell Tumor (GCT) of the bone is a locally osteolytic tumor made up of mononuclear ovoid stromal cells and multinucleated giant cells. It commonly affects long bones like the distal femur and proximal tibia, but can also develop in the cervical spine during the third and fourth decades of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Presentation of case:<\/jats:title>\n                    <jats:p>A 20-year-old female presented to the clinic with a complaint of neck pain persisting for one month. Clinical examination revealed bilateral radiculopathy in the upper limb, which was also associated with pain in the left shoulder and elbow. Imaging revealed a destructive lesion in the 7th cervical vertebra (C7). A biopsy was done which indicated a giant cell tumor (GCT). A C7 corpectomy was performed, which included the removal of the C7 vertebral body and application of a cage. At the two-year follow-up, the patient remained asymptomatic, and radiographs showed no signs of recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>A Giant Cell Tumor (GCT) occurring above the sacrum, especially in the cervical spine, is extremely rare. Symptoms of GCT are often nonspecific and can include neck pain, numbness, and weakness in the upper limbs, which are sometimes mistaken for myalgia or disc disease. The main treatment goal for GCT is \u201cen bloc\u201d resection while preserving the joint, though this can be challenging, particularly in spinal cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>It is crucial to acknowledge that GCT can appear in uncommon sites and age groups. Surgeons must have a high level of awareness and perform an adequate preoperative workup, before definitive treatment. The patient should undergo regular follow-ups to detect any recurrence or metastasis at an early stage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2024.110676","type":"journal-article","created":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T11:29:50Z","timestamp":1732879790000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Giant cell tumor of the cervical spine: A case report"],"prefix":"10.1097","volume":"126","author":[{"given":"Omar Abdulaziz","family":"Alolayan","sequence":"first","affiliation":[{"name":"Orthopedic Surgery Department at Prince Sultan Military Medical City, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulrahman Jalwi","family":"Korkoman","sequence":"additional","affiliation":[{"name":"Orthopedic Surgery Department at the University of Bisha, Bisha, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah Adel","family":"Alnasser","sequence":"additional","affiliation":[{"name":"Orthopedic Surgery Department at Prince Sultan Military Medical City, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-38-20260508","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1001\/archsurg.1926.01130120070003","article-title":"Giant cell tumor of bone","volume":"13","author":"Goforth","year":"1926","journal-title":"Arch. 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Bone Joint Surg."},{"key":"R10-38-20260508","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1148\/rg.331125089","article-title":"Giant cell tumor of bone: review, mimics, and new developments in treatment","volume":"33","author":"Chakarun","year":"2013","journal-title":"RadioGraphics"},{"key":"R11-38-20260508","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.2106\/00004623-198365090-00009","article-title":"Surgical treatment of giant-cell tumor of the spine. The experience at the Istituto Ortopedico Rizzoli","volume":"65","author":"Savini","year":"1983","journal-title":"J. Bone Joint Surg."},{"key":"R12-38-20260508","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1097\/00007632-199807150-00020","article-title":"A giant cell tumor of the sacrum or a soft tissue giant cell tumor?","volume":"23","author":"Verhagen","year":"1998","journal-title":"Spine"},{"key":"R13-38-20260508","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1097\/JS9.0000000000000373","article-title":"The SCARE 2023 guideline: updating consensus surgical CAse REport (SCARE) guidelines","volume":"109","author":"Sohrabi","year":"2023","journal-title":"Int. J. Surg."},{"key":"R14-38-20260508","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1097\/01.blo.0000069890.31220.b4","article-title":"Radiation therapy for giant cell tumors of bone","volume":"411","author":"Feigenberg","year":"2003","journal-title":"Clin. Orthop. Relat. Res."}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261224014573?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261224014573?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2024.110676","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T22:01:08Z","timestamp":1778277668000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2024.110676"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":13,"journal-issue":{"issue":"C","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2024.110676","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-08-09","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-27","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}