{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T22:11:45Z","timestamp":1778278305968,"version":"3.51.4"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T00:00:00Z","timestamp":1732752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction and significance:<\/jats:title>\n                    <jats:p>Ewing's sarcoma is a rare tumor occurring in the mediastinum. It is a malignant, aggressive, and rapidly growing tumor that often lacks distinctive clinical or radiological features. Diagnosis is primarily made through histological and immunocytochemical examination. Complete surgical excision followed by chemotherapy is the preferred treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation:<\/jats:title>\n                    <jats:p>We present a case of a child who initially presented with mild respiratory distress. The condition rapidly progressed, leading to an external misdiagnosis and the placement of a chest defibrillator due to misinterpreted findings. The child was referred to our institution, where a large mediastinal mass was diagnosed and surgical intervention was undertaken to completely resect the mass and confirm the diagnosis of Ewing's sarcoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical discussion:<\/jats:title>\n                    <jats:p>It is crucial for medical practitioners, especially surgeons, to include Ewing's sarcoma in the differential diagnosis of mediastinal lesions. This consideration is essential for developing an appropriate surgical intervention plan and subsequent follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our case highlights several important points in clinical practice. It emphasizes the need to avoid relying solely on non-contrast CT scans when a mass is suspected. Additionally, fine-needle aspiration (FNA) should be considered for mass lesions to establish a diagnosis before surgical intervention, as some conditions, such as lymphoma, may not require surgery. Our case also demonstrates the successful removal of a large chest mass through a posterior lateral thoracic approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2024.110699","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T03:33:36Z","timestamp":1733196816000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["A unique pediatric thoracic tumor: A case report of mediastinal Ewing sarcoma"],"prefix":"10.1097","volume":"126","author":[{"given":"Kamar","family":"Shaker","sequence":"first","affiliation":[{"name":"Damascus University, University pediatrics Hospital, Damascus, Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khaled","family":"Alomar","sequence":"additional","affiliation":[{"name":"Children's Hospital, University of Damascus, Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zaher","family":"Alabed","sequence":"additional","affiliation":[{"name":"Damascus University, University pediatrics Hospital, Damascus, Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alhasan","family":"Rastanawi","sequence":"additional","affiliation":[{"name":"Damascus University, University pediatrics Hospital, Damascus, Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghuroub","family":"Alkhayer","sequence":"additional","affiliation":[{"name":"Damascus University, Professor of Pediatric Infectious and immunodeficiency Diseases at the University Children's Hospital, Damascus, Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed Abd","family":"Alkader","sequence":"additional","affiliation":[{"name":"Damascus University, University pediatrics' Hospital, Damascus, Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"issue":"19","key":"R1-57-20260508","doi-asserted-by":"crossref","first-page":"4994","DOI":"10.1158\/0008-5472.CAN-20-3837","article-title":"Unraveling Ewing sarcoma tumorigenesis originating from patient-derived mesenchymal stem cells","volume":"81","author":"Sole","year":"2021","journal-title":"Cancer Res."},{"issue":"4","key":"R2-57-20260508","first-page":"363","article-title":"A case of extraskeletal Ewing sarcoma originating from the visceral pleura","volume":"15","author":"Karatziou","year":"2011","journal-title":"Hippokratia"},{"issue":"12","key":"R3-57-20260508","first-page":"1859","article-title":"Extraosseous Ewing sarcoma in children: a systematic review and meta-analysis of clinicodemographic characteristics","volume":"9","author":"Ghandour","year":"2022","journal-title":"Children (Basel)"},{"issue":"1","key":"R4-57-20260508","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1186\/s12887-021-02672-6","article-title":"Primary pulmonary Ewing's sarcoma: rare cause of massive hemothorax in a young girl-case report.","volume":"21","author":"Ling","year":"2021","journal-title":"BMC Pediatr."},{"issue":"1","key":"R5-57-20260508","doi-asserted-by":"crossref","first-page":"20220669","DOI":"10.1515\/biol-2022-0669","article-title":"Primary mediastinum Ewing's sarcoma with pleural effusion: a case report and literature review","volume":"18","author":"Li","year":"2023","journal-title":"Open Life Sci."},{"issue":"5","key":"R6-57-20260508","doi-asserted-by":"crossref","first-page":"354","DOI":"10.3892\/ol.2021.12615","article-title":"Extraskeletal Ewing sarcoma: diagnosis, management and prognosis","volume":"21","author":"Abboud","year":"2021","journal-title":"Oncol. 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Case Reports"},{"issue":"2","key":"R12-57-20260508","doi-asserted-by":"crossref","first-page":"121","DOI":"10.4103\/1817-1737.109834","article-title":"A case of primary mediastinal Ewing's sarcoma \/ primitive neuroectodermal tumor presenting with initial compression of superior vena cava","volume":"8","author":"Reali","year":"2013","journal-title":"Ann. Thorac. Med."},{"issue":"12","key":"R13-57-20260508","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1016\/j.annonc.2021.08.1995","article-title":"Bone sarcomas: ESMO-EURACAN-GENTURIS-ERN PaedCan clinical practice guideline for diagnosis, treatment and follow-up","volume":"32","author":"Strauss","year":"2021","journal-title":"Ann. 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