{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T21:36:02Z","timestamp":1793741762619,"version":"4.6.1"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T00:00:00Z","timestamp":1732838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction and importance:<\/jats:title>\n                    <jats:p>Leptomeningeal carcinomatosis (LC) is an uncommon but severe complication of advanced esophageal adenocarcinoma. Typically diagnosed through MRI and cerebrospinal fluid analysis, LC carries a poor prognosis despite aggressive management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation:<\/jats:title>\n                    <jats:p>A 64-year-old male with a history of coronary artery disease, diabetes, and other comorbidities presented with progressive dysphagia. Diagnostic imaging and biopsy confirmed esophageal adenocarcinoma with local invasion and distant metastases, including mediastinal lymphadenopathy. Despite treatment with chemotherapy, radiation, and surgical interventions such as jejunostomy tube placement, the patient developed neurological symptoms suggestive of LC. MRI confirmed leptomeningeal involvement, and cerebrospinal fluid analysis revealed malignant cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical discussion:<\/jats:title>\n                    <jats:p>Management focused on palliative care, including chemotherapy and radiation. The patient's condition deteriorated rapidly, consistent with the poor prognosis associated with LC in esophageal cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This case discusses the importance of early detection and intervention in managing esophageal adenocarcinoma, particularly when neurological symptoms suggest central nervous system involvement. Despite advances in cancer treatment, LC remains a difficult condition to manage, with limited effective therapeutic options.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2024.110708","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T13:03:24Z","timestamp":1733231004000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Leptomeningeal carcinomatosis in advanced esophageal adenocarcinoma: A case report on presentation and diagnosis"],"prefix":"10.1097","volume":"126","author":[{"given":"Nathaniel","family":"Grabill","sequence":"first","affiliation":[{"name":"Northeast Georgia Health System Inc, General Surgery Department, 743 Spring Street NE, Gainesville, GA 30501, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mena","family":"Louis","sequence":"additional","affiliation":[{"name":"Northeast Georgia Health System Inc, General Surgery Department, 743 Spring Street NE, Gainesville, GA 30501, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Adams","sequence":"additional","affiliation":[{"name":"Northeast Georgia Health System Inc, General Surgery Department, 743 Spring Street NE, Gainesville, GA 30501, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Gherasim","sequence":"additional","affiliation":[{"name":"Northeast Georgia Health System Inc, Pathology Department, 743 Spring Street NE, Gainesville, GA 30501, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumi","family":"So","sequence":"additional","affiliation":[{"name":"Northeast Georgia Health System Inc, Pathology Department, 743 Spring Street NE, Gainesville, GA 30501, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Stevens","sequence":"additional","affiliation":[{"name":"Northeast Georgia Health System Inc, Trauma and Acute Care Surgery Department, 743 Spring Street NE, Gainesville, GA 30501, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"1","key":"R1-66-20260508","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13010141","article-title":"Global burden, risk factors, and trends of esophageal cancer: an analysis of cancer registries from 48 countries","volume":"13","author":"Huang","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"1","key":"R2-66-20260508","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/1759-7714.14745","article-title":"Epidemiology of esophageal cancer in 2020 and projections to 2030 and 2040","volume":"14","author":"Liu","year":"2023","journal-title":"Thorac. Cancer"},{"issue":"3","key":"R3-66-20260508","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1590\/0102-6720201600030003","article-title":"Prognostic factors and survival analysis in esophageal carcinoma","volume":"29","author":"Tustumi","year":"2016","journal-title":"Arq. Bras. Cir. Dig."},{"issue":"2","key":"R4-66-20260508","first-page":"101","article-title":"Esophageal carcinoma: long-term survival in consecutive series of patients through a retrospective cohort study","volume":"7","author":"Delpisheh","year":"2014","journal-title":"Gastroenterol. Hepatol. Bed Bench"},{"issue":"6","key":"R5-66-20260508","first-page":"620","article-title":"The changing profile of esophageal cancer presentation and its implication for diagnosis","volume":"99","author":"Gibbs","year":"2007","journal-title":"J. Natl. Med. Assoc."},{"issue":"3","key":"R6-66-20260508","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1007\/s11605-009-1109-y","article-title":"Delay in diagnostic workup and treatment of esophageal cancer","volume":"14","author":"Grotenhuis","year":"2010","journal-title":"J. Gastrointest. Surg."},{"issue":"5","key":"R7-66-20260508","doi-asserted-by":"crossref","first-page":"269","DOI":"10.3949\/ccjm.89a.21053","article-title":"Esophageal adenocarcinoma: a dire need for early detection and treatment","volume":"89","author":"Joseph","year":"2022","journal-title":"Cleve. Clin. J. Med."},{"issue":"8","key":"R8-66-20260508","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/s00535-019-01593-7","article-title":"What is causing the rising incidence of esophageal adenocarcinoma in the west and will it also happen in the east?","volume":"54","author":"McColl","year":"2019","journal-title":"J. Gastroenterol."},{"issue":"2","key":"R9-66-20260508","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1053\/j.gastro.2017.08.023","article-title":"Epidemiology of esophageal squamous cell carcinoma","volume":"154","author":"Abnet","year":"2018","journal-title":"Gastroenterology"},{"issue":"2","key":"R10-66-20260508","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1053\/j.gastro.2017.09.046","article-title":"Insights into the pathophysiology of esophageal adenocarcinoma","volume":"154","author":"Quante","year":"2018","journal-title":"Gastroenterology"},{"key":"R11-66-20260508","article-title":"Mechanisms of esophageal cancer metastasis and treatment progress","volume":"14","author":"Wang","year":"2023","journal-title":"Front. Immunol."},{"issue":"3","key":"R12-66-20260508","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1055\/s-0040-1713576","article-title":"Leptomeningeal carcinomatosis secondary to esophageal cancer diagnosed on cytology","volume":"11","author":"Jagtap","year":"2020","journal-title":"J. Neurosci. Rural Pract."},{"issue":"2","key":"R13-66-20260508","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1053\/ctrv.1999.0119","article-title":"Leptomeningeal carcinomatosis","volume":"25","author":"Grossman","year":"1999","journal-title":"Cancer Treat. Rev."},{"issue":"8","key":"R14-66-20260508","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1111\/dote.12276","article-title":"Leptomeningeal carcinomatosis in esophageal cancer: a case series and systematic review of the literature","volume":"28","author":"Lukas","year":"2015","journal-title":"Dis. Esophagus"},{"key":"R15-66-20260508","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2015-210974","article-title":"Leptomeningeal carcinomatosis from oesophageal cancer, presenting as meningitis","volume":"2016","author":"Ahmed","year":"2016","journal-title":"BMJ Case Rep."},{"issue":"34","key":"R16-66-20260508","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000016653","article-title":"Brain metastases from esophageal cancer: a retrospective analysis of the outcome after surgical resection followed by radiotherapy","volume":"98","author":"Stavrinou","year":"2019","journal-title":"Medicine"},{"key":"R17-66-20260508","doi-asserted-by":"crossref","first-page":"302","DOI":"10.3389\/fonc.2018.00302","article-title":"Patterns of distant metastasis between histological types in esophageal cancer","volume":"8","author":"Wu","year":"2018","journal-title":"Front. Oncol."},{"issue":"2","key":"R18-66-20260508","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.athoracsur.2019.09.028","article-title":"Incidence and risk factors for isolated esophageal cancer recurrence to the brain","volume":"109","author":"Nobel","year":"2020","journal-title":"Ann. Thorac. Surg."},{"issue":"1","key":"R19-66-20260508","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s11060-024-04576-8","article-title":"Leptomeningeal carcinomatosis and brain metastases in gastroesophageal carcinoma: a real-world analysis of clinical and pathologic characteristics and outcomes","volume":"167","author":"Baccili Cury Megid","year":"2024","journal-title":"J. Neuro-Oncol."},{"issue":"10","key":"R20-66-20260508","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2019-230114","article-title":"Palliative approach to leptomeningeal carcinomatosis in oesophagogastric junction cancer","volume":"12","author":"Cunha","year":"2019","journal-title":"BMJ Case Rep."},{"key":"R21-66-20260508","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.12688\/f1000research.11902.1","article-title":"Advancing psychosocial care in cancer patients","volume":"6","author":"Grassi","year":"2017","journal-title":"F1000Res"},{"key":"R22-66-20260508","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyg.2023.1087083","article-title":"Patients' representation of oncological disease: psychological aspects in the cancer journey","volume":"14","author":"Durosini","year":"2023","journal-title":"Front. Psychol."},{"issue":"5","key":"R23-66-20260508","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1177\/0269216316663499","article-title":"Sympathy, empathy, and compassion: a grounded theory study of palliative care patients' understandings, experiences, and preferences","volume":"31","author":"Sinclair","year":"2017","journal-title":"Palliat. Med."},{"issue":"6","key":"R24-66-20260508","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1177\/1744987121997890","article-title":"Exploring the perceptions of dignity among patients and nurses in hospital and community settings: an integrative review","volume":"26","author":"Stephen Ekpenyong","year":"2021","journal-title":"J. Res. Nurs."},{"issue":"5","key":"R25-66-20260508","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1097\/JS9.0000000000000373","article-title":"The SCARE 2023 guideline: updating consensus Surgical CAse REport (SCARE) guidelines","volume":"109","author":"Sohrabi","year":"2023","journal-title":"Int. J. Surg. Lond. Engl."}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261224014895?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261224014895?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2024.110708","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T22:01:41Z","timestamp":1778277701000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2024.110708"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":25,"journal-issue":{"issue":"C","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2024.110708","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-09-26","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-29","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}