{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T22:12:28Z","timestamp":1778278348187,"version":"3.51.4"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T00:00:00Z","timestamp":1733356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction and importance:<\/jats:title>\n                    <jats:p>Synovial sarcoma (SS) is a high-grade malignancy, accounting for 2.5-3.5 % of all primary H&amp;N sarcomas and 0.1 % of all H&amp;N cancers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation:<\/jats:title>\n                    <jats:p>A 26-year-old woman presents with dyspnea and dysphonia. Flexible nasofibrolaryngoscopy and CT were performed with evidence of a laryngeal tumor. Total laryngectomy was performed due to a histopathological report of laryngeal synovial sarcoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical discussion:<\/jats:title>\n                    <jats:p>Primary SS of the H&amp;N is rare and accounts for &lt;5 % of all synovial sarcomas and laryngeal-origin SS represents a rare subset within H&amp;N sarcomas. There are 3 different histologic subtypes: biphasic, monophasic and poorly differentiated. Immunohistochemistry plays a crucial role in histologic diagnosis. The optimal treatment of synovial sarcoma is multimodal, depending on its size, location and grade. Radical surgical excision with negative margins is generally accepted as the mainstay of treatment. Disease recurrence is a significant problem, with up to 45 % of patients developing local disease and 33 % developing metastatic disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Laryngeal SS is exceptionally rare, requiring complex, multidisciplinary management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2024.110716","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T10:28:06Z","timestamp":1733740086000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Synovial sarcoma of the larynx, a rare and unusual entity. Case report"],"prefix":"10.1097","volume":"126","author":[{"given":"Jes\u00fas Antonio","family":"Mart\u00edn P\u00e9rez","sequence":"first","affiliation":[{"name":"Surgical Oncology Department, National Medical Center \u201c20 de Noviembre\u201d, Mexico City, MX, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9ctor","family":"Gurrola Machuca","sequence":"additional","affiliation":[{"name":"Surgical Oncology Department, National Medical Center \u201c20 de Noviembre\u201d, Mexico City, MX, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"N\u00fa\u00f1ez Guardado","sequence":"additional","affiliation":[{"name":"Radiation Oncology Department, National Medical Center \u201c20 de Noviembre\u201d, Mexico City, MX, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Carlos","family":"Navarrete Tolentino","sequence":"additional","affiliation":[{"name":"Surgical Oncology Department, National Medical Center \u201c20 de Noviembre\u201d, Mexico City, MX, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego Armando","family":"Acosta Cort\u00e9s","sequence":"additional","affiliation":[{"name":"Surgical Oncology Department, National Medical Center \u201c20 de Noviembre\u201d, Mexico City, MX, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Mart\u00ednez Mijares","sequence":"additional","affiliation":[{"name":"Pathology Department, National Medical Center \u201c20 de Noviembre\u201d, Mexico City, MX. Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"issue":"5","key":"R1-74-20260508","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.jormas.2020.12.001","article-title":"Synovial sarcoma of the head & neck: A review of reported cases in the literature","volume":"122","author":"Stanbouly","year":"2021","journal-title":"J. Stomatol. Oral Maxillofac. Surg."},{"key":"R2-74-20260508","first-page":"6134845","article-title":"Synovial sarcoma of the larynx: report of a case and review of literature","volume":"2017","author":"Narayanan","year":"2017","journal-title":"Case Rep. Otolaryngol."},{"issue":"3","key":"R3-74-20260508","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/s12105-019-01106-1","article-title":"Primary sarcomas of the larynx: A single institutional experience with ten cases","volume":"14","author":"Mantilla","year":"2020","journal-title":"Head Neck Pathol."},{"issue":"10","key":"R4-74-20260508","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1001\/archotol.1975.00780390047013","article-title":"Synovial sarcoma of the laryngopharynx","volume":"101","author":"Gatti","year":"1975","journal-title":"Arch. Otolaryngol."},{"issue":"5","key":"R5-74-20260508","first-page":"448","article-title":"Synovial sarcoma of the larynx","volume":"80","author":"Miller","year":"1975","journal-title":"Trans. Sect. Otolaryngol. Am. Acad. Ophthalmol. Otolaryngol."},{"issue":"January","key":"R6-74-20260508","first-page":"1","article-title":"Synovial sarcoma of the head and neck: A review of reported cases on the clinical characteristics and treatment methods","volume":"10","author":"Quan","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"issue":"2","key":"R7-74-20260508","doi-asserted-by":"crossref","DOI":"10.1177\/0145561319850697","article-title":"Laryngeal synovial sarcoma: A systematic review of the last 40 years of reported cases","volume":"100","author":"Shein","year":"2021","journal-title":"Ear Nose Throat J."},{"issue":"January","key":"R8-74-20260508","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.oraloncology.2018.02.016","article-title":"Primary synovial sarcoma (SS) of larynx: an unusual site","volume":"79","author":"Madabhavi","year":"2018","journal-title":"Oral Oncol."},{"key":"R9-74-20260508","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2024\/7574240","article-title":"Paediatric laryngeal synovial sarcoma: dilemmas and decision-making","volume":"2024","author":"Shein","year":"2024","journal-title":"Case Rep. Otolaryngol."},{"issue":"5","key":"R10-74-20260508","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1097\/JS9.0000000000000373","article-title":"The SCARE 2023 guideline: updating consensus Surgical CAse REport (SCARE) guidelines","volume":"109","author":"Sohrabi","year":"2023","journal-title":"Int. J. Surg."},{"issue":"3","key":"R11-74-20260508","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1007\/s12105-021-01314-8","article-title":"Primary sarcomas of the larynx: A clinicopathologic study of 27 cases","volume":"15","author":"Velez Torres","year":"2021","journal-title":"Head Neck Pathol."},{"issue":"7","key":"R12-74-20260508","doi-asserted-by":"crossref","DOI":"10.1177\/014556131309200717","article-title":"Synovial sarcoma of the larynx treated by supraglottic laryngectomy: case report and literature review","volume":"92","author":"Luna-Ortiz","year":"2013","journal-title":"Ear Nose Throat J."},{"issue":"5","key":"R13-74-20260508","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.anl.2012.11.015","article-title":"Synovial sarcomas of the head and neck: comparative analysis with synovial sarcoma of the extremities","volume":"40","author":"Salcedo-Hern\u00e1ndez","year":"2013","journal-title":"Auris Nasus Larynx"},{"issue":"2","key":"R14-74-20260508","doi-asserted-by":"crossref","first-page":"111","DOI":"10.2478\/raon-2013-0027","article-title":"Poor outcome of comprehensive therapy in a case of laryngeal synovial sarcoma","volume":"47","author":"Bao","year":"2013","journal-title":"Radiol. Oncol."},{"issue":"4","key":"R15-74-20260508","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jnci.2018.10.002","article-title":"Laryngeal synovial sarcoma: report of 2 cases","volume":"30","author":"Bellakhdhar","year":"2018","journal-title":"J. Egypt. Natl. Canc. Inst."},{"issue":"3","key":"R16-74-20260508","first-page":"233","article-title":"Synovial sarcoma- a rare tumor of the larynx","volume":"28","author":"Mohammadi","year":"2016","journal-title":"Iran J. Otorhinolaryngol."},{"issue":"3","key":"R17-74-20260508","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.anl.2017.06.007","article-title":"Biphasic synovial sarcoma of the epiglottis: case report and literature review","volume":"45","author":"Wigand","year":"2018","journal-title":"Auris Nasus Larynx"},{"issue":"1","key":"R18-74-20260508","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/S1368-8375(02)00032-5","article-title":"Management of sarcomas of the head and neck in adults","volume":"39","author":"Pellitteri","year":"2003","journal-title":"Oral Oncol."},{"issue":"6","key":"R19-74-20260508","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s11864-005-0024-z","article-title":"Diagnosis and management of synovial sarcoma","volume":"6","author":"Randall","year":"2005","journal-title":"Curr. Treat. Options Oncol."},{"issue":"9092","key":"R20-74-20260508","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1016\/S0140-6736(97)08165-8","article-title":"Adjuvant chemotherapy for localised resectable soft-tissue sarcoma of adults: meta-analysis of individual data. Sarcoma Meta-analysis Collaboration","volume":"350","year":"1997","journal-title":"Lancet (London, England)"},{"issue":"1","key":"R21-74-20260508","doi-asserted-by":"crossref","first-page":"381","DOI":"10.3892\/ol.2014.2634","article-title":"Tumor size predicts prognosis of head and neck synovial cell sarcoma","volume":"9","author":"Wushou","year":"2015","journal-title":"Oncol. Lett."},{"issue":"8","key":"R22-74-20260508","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1200\/JCO.2003.07.008","article-title":"Synovial sarcoma of childhood and adolescence: a multicenter, multivariate analysis of outcome","volume":"21","author":"Okcu","year":"2003","journal-title":"J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol."},{"issue":"8","key":"R23-74-20260508","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1002\/hed.20564","article-title":"Survival in patients with synovial sarcoma of the head and neck: association with tumor location, size, and extension","volume":"29","author":"Harb","year":"2007","journal-title":"Head Neck"},{"key":"R24-74-20260508","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.oraloncology.2016.12.021","article-title":"A clinicopathologic study on SS18 fusion positive head and neck synovial sarcomas","volume":"66","author":"Owosho","year":"2017","journal-title":"Oral Oncol."}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261224014974?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261224014974?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2024.110716","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T22:02:01Z","timestamp":1778277721000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2024.110716"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":24,"journal-issue":{"issue":"C","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2024.110716","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-09-24","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-05","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}